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Gene: IMP4 |
Gene summary for IMP4 |
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Gene information | Species | Human | Gene symbol | IMP4 | Gene ID | 92856 |
Gene name | IMP U3 small nucleolar ribonucleoprotein 4 | |
Gene Alias | BXDC4 | |
Cytomap | 2q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96G21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92856 | IMP4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.86e-08 | 4.64e-01 | -0.0811 |
92856 | IMP4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.48e-05 | 2.37e-01 | -0.1954 |
92856 | IMP4 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.06e-07 | 2.62e-01 | -0.1464 |
92856 | IMP4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-07 | 4.45e-01 | -0.059 |
92856 | IMP4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.53e-02 | 2.68e-01 | -0.0179 |
92856 | IMP4 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.84e-08 | 3.47e-01 | 0.096 |
92856 | IMP4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.62e-07 | 2.45e-01 | 0.0674 |
92856 | IMP4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.08e-09 | 3.16e-01 | 0.294 |
92856 | IMP4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.73e-04 | 7.12e-01 | 0.3487 |
92856 | IMP4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.69e-05 | 3.74e-01 | 0.281 |
92856 | IMP4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.71e-14 | 4.81e-01 | 0.3859 |
92856 | IMP4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.37e-08 | 2.93e-01 | 0.3005 |
92856 | IMP4 | LZE2T | Human | Esophagus | ESCC | 2.13e-04 | 8.58e-01 | 0.082 |
92856 | IMP4 | LZE4T | Human | Esophagus | ESCC | 1.51e-14 | 5.40e-01 | 0.0811 |
92856 | IMP4 | LZE7T | Human | Esophagus | ESCC | 1.77e-08 | 5.86e-01 | 0.0667 |
92856 | IMP4 | LZE8T | Human | Esophagus | ESCC | 1.36e-11 | 3.92e-01 | 0.067 |
92856 | IMP4 | LZE20T | Human | Esophagus | ESCC | 1.44e-06 | 2.23e-01 | 0.0662 |
92856 | IMP4 | LZE22T | Human | Esophagus | ESCC | 2.07e-04 | 5.19e-01 | 0.068 |
92856 | IMP4 | LZE24T | Human | Esophagus | ESCC | 1.07e-18 | 6.70e-01 | 0.0596 |
92856 | IMP4 | LZE6T | Human | Esophagus | ESCC | 2.32e-04 | 3.78e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009895111 | Esophagus | ESCC | negative regulation of catabolic process | 201/8552 | 320/18723 | 3.88e-10 | 1.05e-08 | 201 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IMP4 | SNV | Missense_Mutation | rs775933151 | c.811N>C | p.Val271Leu | p.V271L | Q96G21 | protein_coding | tolerated(0.23) | benign(0.017) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
IMP4 | insertion | In_Frame_Ins | novel | c.770_771insCACAGATTCTCCCGGACCCACGTGGAAGCG | p.Met257delinsIleThrAspSerProGlyProThrTrpLysArg | p.M257delinsITDSPGPTWKR | Q96G21 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
IMP4 | SNV | Missense_Mutation | rs759092541 | c.673N>A | p.Asp225Asn | p.D225N | Q96G21 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
IMP4 | SNV | Missense_Mutation | rs142127211 | c.338G>A | p.Arg113Gln | p.R113Q | Q96G21 | protein_coding | tolerated(0.06) | benign(0.298) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IMP4 | SNV | Missense_Mutation | rs144350259 | c.581N>A | p.Arg194His | p.R194H | Q96G21 | protein_coding | deleterious(0.03) | benign(0.076) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
IMP4 | SNV | Missense_Mutation | c.324C>G | p.Phe108Leu | p.F108L | Q96G21 | protein_coding | tolerated(0.23) | benign(0.06) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IMP4 | SNV | Missense_Mutation | c.119G>T | p.Arg40Leu | p.R40L | Q96G21 | protein_coding | deleterious(0) | benign(0) | TCGA-AX-A0IW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | SD | |
IMP4 | SNV | Missense_Mutation | c.820N>T | p.Arg274Cys | p.R274C | Q96G21 | protein_coding | tolerated(0.06) | benign(0.225) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
IMP4 | SNV | Missense_Mutation | rs117152505 | c.403G>A | p.Asp135Asn | p.D135N | Q96G21 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
IMP4 | SNV | Missense_Mutation | rs775723557 | c.821N>A | p.Arg274His | p.R274H | Q96G21 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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