Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: IMMT

Gene summary for IMMT

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

IMMT

Gene ID

10989

Gene nameinner membrane mitochondrial protein
Gene AliasHMP
Cytomap2p11.2
Gene Typeprotein-coding
GO ID

GO:0006873

UniProtAcc

Q16891


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10989IMMTHTA11_347_2000001011HumanColorectumAD5.40e-033.12e-01-0.1954
10989IMMTA002-C-010HumanColorectumFAP9.60e-03-1.15e-010.242
10989IMMTA001-C-207HumanColorectumFAP1.39e-02-2.17e-010.1278
10989IMMTA015-C-203HumanColorectumFAP1.44e-22-2.84e-01-0.1294
10989IMMTA015-C-204HumanColorectumFAP3.52e-03-3.05e-01-0.0228
10989IMMTA002-C-201HumanColorectumFAP1.16e-06-2.17e-010.0324
10989IMMTA002-C-203HumanColorectumFAP1.56e-05-1.88e-010.2786
10989IMMTA001-C-119HumanColorectumFAP4.25e-05-2.92e-01-0.1557
10989IMMTA001-C-108HumanColorectumFAP3.27e-13-2.34e-01-0.0272
10989IMMTA002-C-205HumanColorectumFAP2.84e-12-2.56e-01-0.1236
10989IMMTA001-C-104HumanColorectumFAP2.00e-05-1.43e-010.0184
10989IMMTA015-C-006HumanColorectumFAP2.27e-08-1.88e-01-0.0994
10989IMMTA015-C-106HumanColorectumFAP3.01e-10-1.93e-01-0.0511
10989IMMTA002-C-114HumanColorectumFAP3.27e-10-2.63e-01-0.1561
10989IMMTA015-C-104HumanColorectumFAP1.70e-23-2.70e-01-0.1899
10989IMMTA001-C-014HumanColorectumFAP1.27e-09-2.28e-010.0135
10989IMMTA002-C-016HumanColorectumFAP1.58e-11-2.52e-010.0521
10989IMMTA015-C-002HumanColorectumFAP7.97e-07-3.06e-01-0.0763
10989IMMTA001-C-203HumanColorectumFAP2.22e-07-1.37e-01-0.0481
10989IMMTA002-C-116HumanColorectumFAP8.36e-24-2.59e-01-0.0452
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0007006ColorectumADmitochondrial membrane organization48/3918116/187234.53e-071.72e-0548
GO:0007007ColorectumADinner mitochondrial membrane organization18/391838/187232.45e-043.09e-0318
GO:0051560ColorectumADmitochondrial calcium ion homeostasis13/391826/187239.41e-048.92e-0313
GO:00515603ColorectumFAPmitochondrial calcium ion homeostasis9/262226/187236.73e-034.14e-029
GO:00515604ColorectumCRCmitochondrial calcium ion homeostasis9/207826/187231.35e-031.49e-029
GO:000700619EsophagusESCCmitochondrial membrane organization93/8552116/187232.16e-141.11e-1293
GO:000700713EsophagusESCCinner mitochondrial membrane organization31/855238/187235.93e-066.10e-0531
GO:00424072EsophagusESCCcristae formation13/855216/187234.05e-031.62e-0213
GO:00070065LiverCirrhoticmitochondrial membrane organization57/4634116/187231.13e-084.29e-0757
GO:005156011LiverCirrhoticmitochondrial calcium ion homeostasis15/463426/187233.43e-042.93e-0315
GO:00070073LiverCirrhoticinner mitochondrial membrane organization19/463438/187236.75e-045.06e-0319
GO:000700612LiverHCCmitochondrial membrane organization80/7958116/187237.09e-091.81e-0780
GO:000700711LiverHCCinner mitochondrial membrane organization28/795838/187239.60e-058.34e-0428
GO:005156021LiverHCCmitochondrial calcium ion homeostasis20/795826/187233.82e-042.61e-0320
GO:0042407LiverHCCcristae formation12/795816/187238.74e-033.40e-0212
GO:000700610Oral cavityOSCCmitochondrial membrane organization85/7305116/187236.29e-143.40e-1285
GO:00070075Oral cavityOSCCinner mitochondrial membrane organization27/730538/187236.23e-055.08e-0427
GO:00515607Oral cavityOSCCmitochondrial calcium ion homeostasis18/730526/187231.75e-038.28e-0318
GO:00424071Oral cavityOSCCcristae formation12/730516/187233.83e-031.57e-0212
GO:000700623Oral cavityEOLPmitochondrial membrane organization25/2218116/187232.06e-031.31e-0225
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
IMMTSNVMissense_Mutationnovelc.1198G>Tp.Asp400Tyrp.D400YQ16891protein_codingdeleterious(0)probably_damaging(0.999)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
IMMTSNVMissense_Mutationc.652N>Cp.Glu218Glnp.E218QQ16891protein_codingtolerated(0.13)benign(0.01)TCGA-C8-A12Z-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
IMMTSNVMissense_Mutationc.391N>Gp.Gln131Glup.Q131EQ16891protein_codingtolerated(1)benign(0.001)TCGA-D8-A1XW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycin+cyclophosphamideSD
IMMTSNVMissense_Mutationnovelc.769N>Gp.Lys257Glup.K257EQ16891protein_codingtolerated(0.08)possibly_damaging(0.7)TCGA-EW-A6SB-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
IMMTSNVMissense_Mutationrs114088948c.1573C>Tp.Arg525Cysp.R525CQ16891protein_codingdeleterious(0)possibly_damaging(0.832)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
IMMTSNVMissense_Mutationrs750446231c.317C>Tp.Ser106Leup.S106LQ16891protein_codingtolerated(0.25)benign(0.322)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
IMMTSNVMissense_Mutationnovelc.2014N>Gp.Gln672Glup.Q672EQ16891protein_codingtolerated(0.6)benign(0.065)TCGA-C5-A2LZ-01Cervixcervical & endocervical cancerFemale>=65III/IVUnknownUnknownPD
IMMTSNVMissense_Mutationc.2095N>Cp.Glu699Glnp.E699QQ16891protein_codingdeleterious(0)possibly_damaging(0.874)TCGA-DG-A2KK-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
IMMTSNVMissense_Mutationc.107C>Tp.Ser36Leup.S36LQ16891protein_codingdeleterious(0.02)benign(0.14)TCGA-EK-A2PG-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
IMMTSNVMissense_Mutationnovelc.2208G>Cp.Gln736Hisp.Q736HQ16891protein_codingdeleterious(0)probably_damaging(1)TCGA-VS-A8QF-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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