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Gene: ILRUN |
Gene summary for ILRUN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ILRUN | Gene ID | 64771 |
| Gene name | inflammation and lipid regulator with UBA-like and NBR1-like domains | |
| Gene Alias | C6orf106 | |
| Cytomap | 6p21.31 | |
| Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q9H6K1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64771 | ILRUN | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.31e-07 | 1.88e-01 | 0.0155 |
| 64771 | ILRUN | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.55e-18 | 4.77e-01 | -0.1808 |
| 64771 | ILRUN | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.05e-20 | 5.26e-01 | -0.0811 |
| 64771 | ILRUN | HTA11_78_2000001011 | Human | Colorectum | AD | 2.07e-15 | 4.23e-01 | -0.1088 |
| 64771 | ILRUN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.17e-33 | 6.12e-01 | -0.1954 |
| 64771 | ILRUN | HTA11_411_2000001011 | Human | Colorectum | SER | 1.35e-12 | 7.18e-01 | -0.2602 |
| 64771 | ILRUN | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.75e-12 | 6.83e-01 | -0.2196 |
| 64771 | ILRUN | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.67e-12 | 3.30e-01 | -0.1207 |
| 64771 | ILRUN | HTA11_83_2000001011 | Human | Colorectum | SER | 4.95e-13 | 3.95e-01 | -0.1526 |
| 64771 | ILRUN | HTA11_696_2000001011 | Human | Colorectum | AD | 2.92e-23 | 4.22e-01 | -0.1464 |
| 64771 | ILRUN | HTA11_866_2000001011 | Human | Colorectum | AD | 2.92e-23 | 3.91e-01 | -0.1001 |
| 64771 | ILRUN | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.06e-25 | 6.06e-01 | -0.059 |
| 64771 | ILRUN | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.94e-06 | 3.33e-01 | -0.1706 |
| 64771 | ILRUN | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.00e-07 | 3.63e-01 | -0.2061 |
| 64771 | ILRUN | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | -0.1462 |
| 64771 | ILRUN | HTA11_546_2000001011 | Human | Colorectum | AD | 6.66e-12 | 3.74e-01 | -0.0842 |
| 64771 | ILRUN | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.08e-04 | 2.52e-01 | -0.0179 |
| 64771 | ILRUN | HTA11_866_3004761011 | Human | Colorectum | AD | 1.27e-12 | 2.72e-01 | 0.096 |
| 64771 | ILRUN | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.79e-07 | 3.63e-01 | 0.0446 |
| 64771 | ILRUN | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.50e-08 | 3.65e-01 | 0.0528 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
| GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0051101 | Colorectum | AD | regulation of DNA binding | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
| GO:1903828 | Colorectum | AD | negative regulation of cellular protein localization | 39/3918 | 117/18723 | 1.18e-03 | 1.06e-02 | 39 |
| GO:0051100 | Colorectum | AD | negative regulation of binding | 50/3918 | 162/18723 | 1.84e-03 | 1.51e-02 | 50 |
| GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
| GO:19001801 | Colorectum | SER | regulation of protein localization to nucleus | 46/2897 | 136/18723 | 8.50e-08 | 5.27e-06 | 46 |
| GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
| GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
| GO:00511011 | Colorectum | SER | regulation of DNA binding | 33/2897 | 118/18723 | 3.70e-04 | 5.71e-03 | 33 |
| GO:00511001 | Colorectum | SER | negative regulation of binding | 40/2897 | 162/18723 | 1.46e-03 | 1.59e-02 | 40 |
| GO:19038281 | Colorectum | SER | negative regulation of cellular protein localization | 30/2897 | 117/18723 | 2.96e-03 | 2.62e-02 | 30 |
| GO:00510988 | Lung | IAC | regulation of binding | 66/2061 | 363/18723 | 2.78e-05 | 7.29e-04 | 66 |
| GO:00511018 | Lung | IAC | regulation of DNA binding | 27/2061 | 118/18723 | 1.63e-04 | 2.93e-03 | 27 |
| GO:00162366 | Lung | IAC | macroautophagy | 51/2061 | 291/18723 | 5.30e-04 | 7.49e-03 | 51 |
| GO:00096156 | Lung | IAC | response to virus | 61/2061 | 367/18723 | 6.75e-04 | 9.12e-03 | 61 |
| GO:00511007 | Lung | IAC | negative regulation of binding | 32/2061 | 162/18723 | 7.30e-04 | 9.60e-03 | 32 |
| GO:00345047 | Lung | IAC | protein localization to nucleus | 50/2061 | 290/18723 | 8.71e-04 | 1.11e-02 | 50 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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