GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:003009922 | Liver | HCC | myeloid cell differentiation | 200/7958 | 381/18723 | 4.64e-05 | 4.49e-04 | 200 |
GO:00028312 | Liver | HCC | regulation of response to biotic stimulus | 173/7958 | 327/18723 | 8.55e-05 | 7.48e-04 | 173 |
GO:00343411 | Liver | HCC | response to interferon-gamma | 82/7958 | 141/18723 | 1.25e-04 | 1.03e-03 | 82 |
GO:004586021 | Liver | HCC | positive regulation of protein kinase activity | 194/7958 | 386/18723 | 1.16e-03 | 6.54e-03 | 194 |
GO:003249611 | Liver | HCC | response to lipopolysaccharide | 174/7958 | 343/18723 | 1.19e-03 | 6.62e-03 | 174 |
GO:003367411 | Liver | HCC | positive regulation of kinase activity | 230/7958 | 467/18723 | 1.72e-03 | 8.95e-03 | 230 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
GO:000223711 | Liver | HCC | response to molecule of bacterial origin | 181/7958 | 363/18723 | 2.58e-03 | 1.24e-02 | 181 |
GO:0050688 | Liver | HCC | regulation of defense response to virus | 41/7958 | 69/18723 | 3.38e-03 | 1.54e-02 | 41 |
GO:00321471 | Liver | HCC | activation of protein kinase activity | 72/7958 | 134/18723 | 5.61e-03 | 2.33e-02 | 72 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL23R | SNV | Missense_Mutation | novel | c.1212A>C | p.Lys404Asn | p.K404N | Q5VWK5 | protein_coding | deleterious(0.01) | benign(0.167) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL23R | SNV | Missense_Mutation | | c.1238N>T | p.Gln413Leu | p.Q413L | Q5VWK5 | protein_coding | deleterious(0.02) | possibly_damaging(0.871) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
IL23R | SNV | Missense_Mutation | | c.263N>T | p.Trp88Leu | p.W88L | Q5VWK5 | protein_coding | tolerated(0.2) | benign(0.08) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
IL23R | SNV | Missense_Mutation | | c.421N>C | p.Asn141His | p.N141H | Q5VWK5 | protein_coding | tolerated(0.29) | benign(0.025) | TCGA-BH-A0GY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyotxan | SD |
IL23R | SNV | Missense_Mutation | novel | c.473A>G | p.Tyr158Cys | p.Y158C | Q5VWK5 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IL23R | SNV | Missense_Mutation | novel | c.697G>C | p.Ala233Pro | p.A233P | Q5VWK5 | protein_coding | deleterious(0.02) | possibly_damaging(0.571) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IL23R | SNV | Missense_Mutation | | c.1136C>T | p.Ser379Leu | p.S379L | Q5VWK5 | protein_coding | deleterious(0) | benign(0.436) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
IL23R | SNV | Missense_Mutation | novel | c.1678T>A | p.Ser560Thr | p.S560T | Q5VWK5 | protein_coding | tolerated(0.13) | benign(0.031) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
IL23R | SNV | Missense_Mutation | rs767996100 | c.1585N>G | p.Asn529Asp | p.N529D | Q5VWK5 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-XS-A8TJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IL23R | SNV | Missense_Mutation | rs772901651 | c.1400N>T | p.Ser467Leu | p.S467L | Q5VWK5 | protein_coding | deleterious(0.01) | benign(0.08) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |