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Gene: IL22RA1 |
Gene summary for IL22RA1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | IL22RA1 | Gene ID | 58985 |
Gene name | interleukin 22 receptor subunit alpha 1 | |
Gene Alias | CRF2-9 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8N6P7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58985 | IL22RA1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.35e-05 | 3.25e-01 | -0.1808 |
58985 | IL22RA1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.16e-04 | 1.23e+00 | -0.2602 |
58985 | IL22RA1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.07e-04 | 5.64e-01 | -0.2196 |
58985 | IL22RA1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.83e-02 | 2.15e-01 | -0.1464 |
58985 | IL22RA1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.04e-06 | 1.06e+00 | 0.3487 |
58985 | IL22RA1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.65e-17 | 5.61e-01 | 0.3859 |
58985 | IL22RA1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.85e-06 | 3.64e-01 | 0.2585 |
58985 | IL22RA1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.55e-05 | 2.54e-01 | 0.3005 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IL24 | IL22RA1_IL20RB | IL24_IL22RA1_IL20RB | IL10 | HNSCC | Precancer |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL22RA1 | SNV | Missense_Mutation | c.344N>T | p.Ser115Phe | p.S115F | Q8N6P7 | protein_coding | deleterious(0.02) | possibly_damaging(0.7) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
IL22RA1 | SNV | Missense_Mutation | c.834N>G | p.Ile278Met | p.I278M | Q8N6P7 | protein_coding | deleterious(0.01) | possibly_damaging(0.467) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
IL22RA1 | SNV | Missense_Mutation | rs747920317 | c.1132N>A | p.Ala378Thr | p.A378T | Q8N6P7 | protein_coding | tolerated(1) | benign(0) | TCGA-AR-A24S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
IL22RA1 | SNV | Missense_Mutation | rs201599737 | c.119C>T | p.Thr40Met | p.T40M | Q8N6P7 | protein_coding | tolerated(0.09) | possibly_damaging(0.904) | TCGA-E2-A1IO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
IL22RA1 | SNV | Missense_Mutation | novel | c.17N>T | p.Thr6Ile | p.T6I | Q8N6P7 | protein_coding | tolerated(0.45) | possibly_damaging(0.568) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL22RA1 | SNV | Missense_Mutation | novel | c.1226N>A | p.Gly409Asp | p.G409D | Q8N6P7 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
IL22RA1 | SNV | Missense_Mutation | c.556N>C | p.Tyr186His | p.Y186H | Q8N6P7 | protein_coding | tolerated(0.17) | probably_damaging(0.993) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IL22RA1 | SNV | Missense_Mutation | c.461N>A | p.Leu154Gln | p.L154Q | Q8N6P7 | protein_coding | tolerated(0.17) | benign(0.108) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
IL22RA1 | SNV | Missense_Mutation | rs750435511 | c.1081N>T | p.Pro361Ser | p.P361S | Q8N6P7 | protein_coding | tolerated(0.15) | benign(0.048) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL22RA1 | SNV | Missense_Mutation | c.1654G>T | p.Asp552Tyr | p.D552Y | Q8N6P7 | protein_coding | deleterious(0.01) | possibly_damaging(0.459) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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