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Gene: IL17RB |
Gene summary for IL17RB |
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Gene information | Species | Human | Gene symbol | IL17RB | Gene ID | 55540 |
Gene name | interleukin 17 receptor B | |
Gene Alias | CRL4 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q9NRM6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55540 | IL17RB | HCC1_Meng | Human | Liver | HCC | 3.36e-11 | -3.19e-02 | 0.0246 |
55540 | IL17RB | HCC2 | Human | Liver | HCC | 1.11e-30 | 4.33e+00 | 0.5341 |
55540 | IL17RB | Pt13.b | Human | Liver | HCC | 1.60e-02 | 4.21e-02 | 0.0251 |
55540 | IL17RB | S014 | Human | Liver | HCC | 1.66e-06 | 5.31e-01 | 0.2254 |
55540 | IL17RB | S027 | Human | Liver | HCC | 4.49e-05 | 5.87e-01 | 0.2446 |
55540 | IL17RB | S028 | Human | Liver | HCC | 5.34e-21 | 8.35e-01 | 0.2503 |
55540 | IL17RB | S029 | Human | Liver | HCC | 2.35e-15 | 7.37e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IL17B | IL17RB | IL17B_IL17RB | IL17 | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL17RB | SNV | Missense_Mutation | c.931N>G | p.Leu311Val | p.L311V | Q9NRM6 | protein_coding | tolerated(0.07) | benign(0.065) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IL17RB | SNV | Missense_Mutation | c.829C>T | p.Pro277Ser | p.P277S | Q9NRM6 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IL17RB | SNV | Missense_Mutation | c.1462N>A | p.Ala488Thr | p.A488T | Q9NRM6 | protein_coding | tolerated(0.6) | benign(0) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IL17RB | insertion | Nonsense_Mutation | novel | c.332_333insCCTGTAATCCCAGCTACTCGG | p.Gln111delinsHisLeuTerSerGlnLeuLeuGly | p.Q111delinsHL*SQLLG | Q9NRM6 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
IL17RB | SNV | Missense_Mutation | novel | c.110A>C | p.Gln37Pro | p.Q37P | Q9NRM6 | protein_coding | tolerated(0.11) | benign(0.185) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IL17RB | SNV | Missense_Mutation | c.1290N>G | p.Phe430Leu | p.F430L | Q9NRM6 | protein_coding | tolerated(0.11) | benign(0.072) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
IL17RB | SNV | Missense_Mutation | c.116N>G | p.Asp39Gly | p.D39G | Q9NRM6 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
IL17RB | SNV | Missense_Mutation | rs772985238 | c.1402C>T | p.Leu468Phe | p.L468F | Q9NRM6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL17RB | SNV | Missense_Mutation | rs749453165 | c.1177N>A | p.Val393Ile | p.V393I | Q9NRM6 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL17RB | SNV | Missense_Mutation | c.684N>T | p.Lys228Asn | p.K228N | Q9NRM6 | protein_coding | tolerated(0.72) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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