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Gene: IKZF3 |
Gene summary for IKZF3 |
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Gene information | Species | Human | Gene symbol | IKZF3 | Gene ID | 22806 |
Gene name | IKAROS family zinc finger 3 | |
Gene Alias | AIO | |
Cytomap | 17q12-q21.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9UKT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22806 | IKZF3 | HCC1 | Human | Liver | HCC | 3.58e-23 | 2.50e+00 | 0.5336 |
22806 | IKZF3 | HCC2 | Human | Liver | HCC | 3.72e-36 | 3.59e+00 | 0.5341 |
22806 | IKZF3 | HCC5 | Human | Liver | HCC | 2.79e-50 | 3.37e+00 | 0.4932 |
22806 | IKZF3 | S028 | Human | Liver | HCC | 4.97e-04 | 2.12e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IKZF3 | SNV | Missense_Mutation | novel | c.1099N>T | p.Pro367Ser | p.P367S | Q9UKT9 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF3 | SNV | Missense_Mutation | novel | c.413G>A | p.Arg138Gln | p.R138Q | Q9UKT9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF3 | SNV | Missense_Mutation | rs762032385 | c.58G>T | p.Ala20Ser | p.A20S | Q9UKT9 | protein_coding | tolerated(0.24) | benign(0.111) | TCGA-BH-A1FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
IKZF3 | SNV | Missense_Mutation | c.38N>T | p.Thr13Ile | p.T13I | Q9UKT9 | protein_coding | tolerated(0.1) | benign(0.019) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IKZF3 | SNV | Missense_Mutation | novel | c.187N>A | p.Glu63Lys | p.E63K | Q9UKT9 | protein_coding | deleterious(0.04) | probably_damaging(0.991) | TCGA-LL-A440-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
IKZF3 | insertion | Nonsense_Mutation | novel | c.1352_1353insTCTTGACTACTAAACTGATTATTT | p.Val451_Tyr452insLeuAspTyrTerThrAspTyrLeu | p.V451_Y452insLDY*TDYL | Q9UKT9 | protein_coding | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
IKZF3 | SNV | Missense_Mutation | novel | c.163N>T | p.Asp55Tyr | p.D55Y | Q9UKT9 | protein_coding | deleterious(0) | possibly_damaging(0.798) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IKZF3 | SNV | Missense_Mutation | c.952N>A | p.Glu318Lys | p.E318K | Q9UKT9 | protein_coding | deleterious(0) | benign(0.241) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IKZF3 | SNV | Missense_Mutation | novel | c.667N>T | p.Arg223Cys | p.R223C | Q9UKT9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IKZF3 | SNV | Missense_Mutation | c.23C>T | p.Ala8Val | p.A8V | Q9UKT9 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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