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Gene: IKBKAP |
Gene summary for IKBKAP |
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Gene information | Species | Human | Gene symbol | IKBKAP | Gene ID | 8518 |
Gene name | elongator acetyltransferase complex subunit 1 | |
Gene Alias | DYS | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0002097 | UniProtAcc | B4E3I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8518 | IKBKAP | P1T-E | Human | Esophagus | ESCC | 4.27e-03 | 1.24e-01 | 0.0875 |
8518 | IKBKAP | P2T-E | Human | Esophagus | ESCC | 5.96e-15 | 2.04e-01 | 0.1177 |
8518 | IKBKAP | P4T-E | Human | Esophagus | ESCC | 1.51e-10 | 1.49e-01 | 0.1323 |
8518 | IKBKAP | P5T-E | Human | Esophagus | ESCC | 1.60e-13 | 1.37e-01 | 0.1327 |
8518 | IKBKAP | P8T-E | Human | Esophagus | ESCC | 1.33e-17 | 7.70e-02 | 0.0889 |
8518 | IKBKAP | P9T-E | Human | Esophagus | ESCC | 1.53e-03 | 5.44e-02 | 0.1131 |
8518 | IKBKAP | P10T-E | Human | Esophagus | ESCC | 1.18e-12 | 1.61e-01 | 0.116 |
8518 | IKBKAP | P11T-E | Human | Esophagus | ESCC | 9.16e-06 | 2.05e-01 | 0.1426 |
8518 | IKBKAP | P12T-E | Human | Esophagus | ESCC | 1.27e-06 | 9.77e-02 | 0.1122 |
8518 | IKBKAP | P15T-E | Human | Esophagus | ESCC | 1.81e-13 | 1.76e-01 | 0.1149 |
8518 | IKBKAP | P16T-E | Human | Esophagus | ESCC | 8.58e-19 | 7.92e-02 | 0.1153 |
8518 | IKBKAP | P20T-E | Human | Esophagus | ESCC | 6.02e-03 | 1.36e-01 | 0.1124 |
8518 | IKBKAP | P21T-E | Human | Esophagus | ESCC | 3.38e-10 | 3.32e-01 | 0.1617 |
8518 | IKBKAP | P22T-E | Human | Esophagus | ESCC | 2.30e-14 | 9.65e-02 | 0.1236 |
8518 | IKBKAP | P23T-E | Human | Esophagus | ESCC | 9.95e-10 | 1.03e-01 | 0.108 |
8518 | IKBKAP | P24T-E | Human | Esophagus | ESCC | 5.43e-08 | 1.15e-01 | 0.1287 |
8518 | IKBKAP | P26T-E | Human | Esophagus | ESCC | 7.09e-16 | 1.48e-01 | 0.1276 |
8518 | IKBKAP | P27T-E | Human | Esophagus | ESCC | 1.16e-14 | 1.11e-01 | 0.1055 |
8518 | IKBKAP | P28T-E | Human | Esophagus | ESCC | 1.44e-12 | 1.89e-01 | 0.1149 |
8518 | IKBKAP | P30T-E | Human | Esophagus | ESCC | 1.61e-10 | 3.78e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IKBKAP | SNV | Missense_Mutation | c.1471N>A | p.Glu491Lys | p.E491K | O95163 | protein_coding | tolerated(0.86) | benign(0.242) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
IKBKAP | SNV | Missense_Mutation | c.1621N>A | p.Glu541Lys | p.E541K | O95163 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IKBKAP | SNV | Missense_Mutation | c.1454N>A | p.Arg485Lys | p.R485K | O95163 | protein_coding | tolerated(0.53) | benign(0.007) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IKBKAP | SNV | Missense_Mutation | c.3640N>C | p.Glu1214Gln | p.E1214Q | O95163 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IKBKAP | SNV | Missense_Mutation | rs780649768 | c.3917N>T | p.Ser1306Leu | p.S1306L | O95163 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IKBKAP | SNV | Missense_Mutation | novel | c.3343N>C | p.Glu1115Gln | p.E1115Q | O95163 | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
IKBKAP | SNV | Missense_Mutation | c.2584C>G | p.Gln862Glu | p.Q862E | O95163 | protein_coding | tolerated(0.12) | benign(0.248) | TCGA-C8-A132-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IKBKAP | SNV | Missense_Mutation | c.1324N>G | p.Leu442Val | p.L442V | O95163 | protein_coding | tolerated(0.14) | possibly_damaging(0.667) | TCGA-D8-A1X7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine+cyclophosphamide+tamoxifen | SD | |
IKBKAP | SNV | Missense_Mutation | novel | c.1947N>T | p.Glu649Asp | p.E649D | O95163 | protein_coding | tolerated(0.25) | benign(0.026) | TCGA-E2-A14O-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD |
IKBKAP | SNV | Missense_Mutation | c.1384A>G | p.Thr462Ala | p.T462A | O95163 | protein_coding | deleterious(0.05) | benign(0.334) | TCGA-E9-A1QZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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