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Gene: IHH |
Gene summary for IHH |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IHH | Gene ID | 3549 |
| Gene name | Indian hedgehog signaling molecule | |
| Gene Alias | BDA1 | |
| Cytomap | 2q35 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14623 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3549 | IHH | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-05 | 2.56e-01 | -0.1808 |
| 3549 | IHH | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.18e-02 | 2.38e-01 | -0.0811 |
| 3549 | IHH | HTA11_78_2000001011 | Human | Colorectum | AD | 1.23e-04 | 2.40e-01 | -0.1088 |
| 3549 | IHH | HTA11_347_2000001011 | Human | Colorectum | AD | 2.45e-15 | 3.72e-01 | -0.1954 |
| 3549 | IHH | HTA11_411_2000001011 | Human | Colorectum | SER | 2.81e-08 | 9.54e-01 | -0.2602 |
| 3549 | IHH | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.82e-04 | 2.28e-01 | -0.1207 |
| 3549 | IHH | HTA11_83_2000001011 | Human | Colorectum | SER | 1.11e-02 | 2.18e-01 | -0.1526 |
| 3549 | IHH | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-08 | 2.56e-01 | -0.1464 |
| 3549 | IHH | HTA11_866_2000001011 | Human | Colorectum | AD | 7.61e-07 | 1.48e-01 | -0.1001 |
| 3549 | IHH | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.19e-02 | 1.94e-01 | -0.059 |
| 3549 | IHH | HTA11_546_2000001011 | Human | Colorectum | AD | 1.09e-04 | 3.37e-01 | -0.0842 |
| 3549 | IHH | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.09e-11 | 2.79e-01 | 0.0674 |
| 3549 | IHH | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.06e-04 | 4.27e-01 | 0.0112 |
| 3549 | IHH | HTA11_7469_2000001011 | Human | Colorectum | AD | 9.26e-10 | 7.08e-01 | -0.0124 |
| 3549 | IHH | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-02 | 2.52e-01 | 0.0588 |
| 3549 | IHH | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-11 | 3.21e-01 | 0.3859 |
| 3549 | IHH | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.25e-05 | 2.01e-01 | 0.3005 |
| 3549 | IHH | HCC2_Meng | Human | Liver | HCC | 1.07e-08 | 8.32e-02 | 0.0107 |
| 3549 | IHH | S014 | Human | Liver | HCC | 4.12e-18 | 6.12e-01 | 0.2254 |
| 3549 | IHH | S015 | Human | Liver | HCC | 9.13e-20 | 7.81e-01 | 0.2375 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
| GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
| GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
| GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
| GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
| GO:0097421 | Colorectum | AD | liver regeneration | 18/3918 | 35/18723 | 6.33e-05 | 1.05e-03 | 18 |
| GO:0060249 | Colorectum | AD | anatomical structure homeostasis | 94/3918 | 314/18723 | 9.37e-05 | 1.42e-03 | 94 |
| GO:0001894 | Colorectum | AD | tissue homeostasis | 81/3918 | 268/18723 | 1.96e-04 | 2.62e-03 | 81 |
| GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
| GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
| GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
| GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
| GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
| GO:0010464 | Colorectum | AD | regulation of mesenchymal cell proliferation | 13/3918 | 28/18723 | 2.22e-03 | 1.75e-02 | 13 |
| GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
| GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
| GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:0031100 | Colorectum | AD | animal organ regeneration | 26/3918 | 76/18723 | 4.94e-03 | 3.32e-02 | 26 |
| GO:0001763 | Colorectum | AD | morphogenesis of a branching structure | 56/3918 | 196/18723 | 6.60e-03 | 4.09e-02 | 56 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa05205 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
| hsa052051 | Colorectum | AD | Proteoglycans in cancer | 70/2092 | 205/8465 | 1.37e-03 | 8.46e-03 | 5.39e-03 | 70 |
| hsa052052 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
| hsa052053 | Colorectum | SER | Proteoglycans in cancer | 58/1580 | 205/8465 | 4.37e-04 | 3.82e-03 | 2.77e-03 | 58 |
| hsa052054 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
| hsa052055 | Colorectum | MSS | Proteoglycans in cancer | 65/1875 | 205/8465 | 8.66e-04 | 5.38e-03 | 3.29e-03 | 65 |
| hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
| hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| IHH | SNV | Missense_Mutation | novel | c.1021N>C | p.Glu341Gln | p.E341Q | Q14623 | protein_coding | deleterious(0) | possibly_damaging(0.492) | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| IHH | SNV | Missense_Mutation | c.842N>G | p.Asp281Gly | p.D281G | Q14623 | protein_coding | tolerated(0.27) | benign(0.239) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| IHH | SNV | Missense_Mutation | c.738N>A | p.Phe246Leu | p.F246L | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| IHH | SNV | Missense_Mutation | c.503N>A | p.Arg168His | p.R168H | Q14623 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| IHH | SNV | Missense_Mutation | c.517G>A | p.Ala173Thr | p.A173T | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| IHH | SNV | Missense_Mutation | c.167N>C | p.Val56Ala | p.V56A | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| IHH | SNV | Missense_Mutation | novel | c.364N>A | p.Trp122Arg | p.W122R | Q14623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| IHH | SNV | Missense_Mutation | novel | c.556N>A | p.Val186Met | p.V186M | Q14623 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| IHH | SNV | Missense_Mutation | novel | c.446N>A | p.Arg149His | p.R149H | Q14623 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| IHH | SNV | Missense_Mutation | novel | c.343N>T | p.Ala115Ser | p.A115S | Q14623 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3549 | IHH | PROTEASE, DRUGGABLE GENOME | TGFBETA1 | 9112395 |
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