Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: IGSF9

Gene summary for IGSF9

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

IGSF9

Gene ID

57549

Gene nameimmunoglobulin superfamily member 9
Gene AliasFP18798
Cytomap1q23.2
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q9P2J2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57549IGSF9HTA11_2487_2000001011HumanColorectumSER5.50e-114.38e-01-0.1808
57549IGSF9HTA11_78_2000001011HumanColorectumAD9.55e-031.81e-01-0.1088
57549IGSF9HTA11_347_2000001011HumanColorectumAD1.24e-143.84e-01-0.1954
57549IGSF9HTA11_411_2000001011HumanColorectumSER9.25e-055.38e-01-0.2602
57549IGSF9HTA11_2112_2000001011HumanColorectumSER7.90e-065.79e-01-0.2196
57549IGSF9HTA11_83_2000001011HumanColorectumSER4.87e-063.99e-01-0.1526
57549IGSF9HTA11_696_2000001011HumanColorectumAD1.07e-174.23e-01-0.1464
57549IGSF9HTA11_1391_2000001011HumanColorectumAD3.65e-021.76e-01-0.059
57549IGSF9HTA11_5212_2000001011HumanColorectumAD3.20e-074.83e-01-0.2061
57549IGSF9HTA11_99999970781_79442HumanColorectumMSS4.90e-051.76e-010.294
57549IGSF9HTA11_99999971662_82457HumanColorectumMSS1.52e-031.97e-010.3859
57549IGSF9HTA11_99999974143_84620HumanColorectumMSS1.64e-092.65e-010.3005
57549IGSF9LZE24THumanEsophagusESCC1.20e-051.57e-010.0596
57549IGSF9P1T-EHumanEsophagusESCC1.20e-072.65e-010.0875
57549IGSF9P2T-EHumanEsophagusESCC1.15e-591.06e+000.1177
57549IGSF9P4T-EHumanEsophagusESCC2.88e-204.54e-010.1323
57549IGSF9P5T-EHumanEsophagusESCC3.60e-111.45e-010.1327
57549IGSF9P8T-EHumanEsophagusESCC6.30e-053.45e-020.0889
57549IGSF9P9T-EHumanEsophagusESCC1.04e-132.96e-010.1131
57549IGSF9P10T-EHumanEsophagusESCC1.88e-153.20e-010.116
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0007409ColorectumADaxonogenesis122/3918418/187233.36e-056.15e-04122
GO:0061564ColorectumADaxon development132/3918467/187238.40e-051.31e-03132
GO:0016358ColorectumADdendrite development69/3918243/187233.32e-032.42e-0269
GO:0050808ColorectumADsynapse organization112/3918426/187234.25e-032.92e-02112
GO:0007411ColorectumADaxon guidance64/3918227/187235.41e-033.55e-0264
GO:0050807ColorectumADregulation of synapse organization60/3918211/187235.67e-033.64e-0260
GO:0097485ColorectumADneuron projection guidance64/3918228/187236.02e-033.78e-0264
GO:00163581ColorectumSERdendrite development58/2897243/187233.82e-045.81e-0358
GO:00074111ColorectumSERaxon guidance51/2897227/187233.29e-032.82e-0251
GO:00974851ColorectumSERneuron projection guidance51/2897228/187233.61e-033.03e-0251
GO:00615641ColorectumSERaxon development94/2897467/187233.78e-033.13e-0294
GO:00074091ColorectumSERaxonogenesis84/2897418/187236.20e-034.49e-0284
GO:00508081ColorectumSERsynapse organization85/2897426/187237.17e-034.99e-0285
GO:00074092ColorectumMSSaxonogenesis105/3467418/187234.32e-045.23e-03105
GO:00615642ColorectumMSSaxon development115/3467467/187235.33e-046.00e-03115
GO:00163582ColorectumMSSdendrite development65/3467243/187239.41e-049.50e-0365
GO:00508082ColorectumMSSsynapse organization101/3467426/187233.96e-032.89e-02101
GO:006156415EsophagusESCCaxon development251/8552467/187232.41e-041.49e-03251
GO:000740915EsophagusESCCaxonogenesis219/8552418/187233.14e-031.31e-02219
GO:001635816EsophagusESCCdendrite development130/8552243/187238.33e-032.95e-02130
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
IGSF9SNVMissense_Mutationnovelc.1301N>Cp.Arg434Prop.R434PQ9P2J2protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A2-A3Y0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
IGSF9SNVMissense_Mutationnovelc.2893N>Gp.Ser965Alap.S965AQ9P2J2protein_codingtolerated(0.37)benign(0.097)TCGA-A8-A085-01Breastbreast invasive carcinomaMale<65I/IIHormone TherapytamoxiphenSD
IGSF9SNVMissense_Mutationnovelc.866N>Cp.Leu289Prop.L289PQ9P2J2protein_codingtolerated(0.35)benign(0.003)TCGA-A8-A09Q-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
IGSF9SNVMissense_Mutationc.1953G>Tp.Lys651Asnp.K651NQ9P2J2protein_codingtolerated(0.61)benign(0.079)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
IGSF9SNVMissense_Mutationnovelc.2802G>Tp.Glu934Aspp.E934DQ9P2J2protein_codingdeleterious(0.01)probably_damaging(0.97)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
IGSF9SNVMissense_Mutationnovelc.489N>Gp.Ser163Argp.S163RQ9P2J2protein_codingdeleterious(0)benign(0.405)TCGA-AN-A0G0-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
IGSF9SNVMissense_Mutationnovelc.912N>Ap.Ser304Argp.S304RQ9P2J2protein_codingdeleterious(0)probably_damaging(0.986)TCGA-C8-A275-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
IGSF9insertionIn_Frame_Insnovelc.306_307insTGCTGTGTTGGAAGTGCAp.Asp102_Gln103insCysCysValGlySerAlap.D102_Q103insCCVGSAQ9P2J2protein_codingTCGA-A8-A079-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
IGSF9insertionFrame_Shift_Insnovelc.2892_2893insCp.Ser965LeufsTer37p.S965Lfs*37Q9P2J2protein_codingTCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
IGSF9insertionFrame_Shift_Insnovelc.2891_2892insCAGTCATCTCTATGACGGTCCCCTGp.Phe966HisfsTer44p.F966Hfs*44Q9P2J2protein_codingTCGA-AR-A0TY-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPaclitaxelPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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