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Gene: IGSF6 |
Gene summary for IGSF6 |
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Gene information | Species | Human | Gene symbol | IGSF6 | Gene ID | 10261 |
Gene name | immunoglobulin superfamily member 6 | |
Gene Alias | DORA | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O95976 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10261 | IGSF6 | HCC1_Meng | Human | Liver | HCC | 1.07e-04 | -2.67e-03 | 0.0246 |
10261 | IGSF6 | Pt13.a | Human | Liver | HCC | 9.92e-13 | 4.24e-01 | 0.021 |
10261 | IGSF6 | Pt13.c | Human | Liver | HCC | 1.33e-20 | 8.19e-01 | 0.0076 |
10261 | IGSF6 | Pt14.d | Human | Liver | HCC | 5.43e-21 | 6.55e-01 | 0.0143 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGSF6 | insertion | Nonsense_Mutation | novel | c.174_175insTAAATTATAAATAAGTTAAGG | p.Cys58_Pro59insTer | p.C58_P59ins* | O95976 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
IGSF6 | insertion | In_Frame_Ins | novel | c.172_173insCATCTGTCA | p.Cys58delinsSerSerValSer | p.C58delinsSSVS | O95976 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
IGSF6 | SNV | Missense_Mutation | novel | c.591N>C | p.Lys197Asn | p.K197N | O95976 | protein_coding | tolerated(0.06) | possibly_damaging(0.521) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
IGSF6 | SNV | Missense_Mutation | c.550C>G | p.Leu184Val | p.L184V | O95976 | protein_coding | tolerated(0.42) | possibly_damaging(0.616) | TCGA-RU-A8FL-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
IGSF6 | SNV | Missense_Mutation | novel | c.573N>C | p.Glu191Asp | p.E191D | O95976 | protein_coding | tolerated(0.08) | possibly_damaging(0.814) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IGSF6 | SNV | Missense_Mutation | rs373342802 | c.205N>T | p.Arg69Cys | p.R69C | O95976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGSF6 | SNV | Missense_Mutation | rs758042522 | c.439C>T | p.Leu147Phe | p.L147F | O95976 | protein_coding | tolerated(0.12) | benign(0.026) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGSF6 | SNV | Missense_Mutation | novel | c.689N>C | p.Glu230Ala | p.E230A | O95976 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
IGSF6 | SNV | Missense_Mutation | rs373342802 | c.205N>T | p.Arg69Cys | p.R69C | O95976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
IGSF6 | SNV | Missense_Mutation | rs769159530 | c.662N>G | p.Gln221Arg | p.Q221R | O95976 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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