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Gene: IGSF11 |
Gene summary for IGSF11 |
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Gene information | Species | Human | Gene symbol | IGSF11 | Gene ID | 152404 |
Gene name | immunoglobulin superfamily member 11 | |
Gene Alias | BT-IgSF | |
Cytomap | 3q13.32 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q5DX21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152404 | IGSF11 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.17e-02 | 6.69e-01 | -0.2602 |
152404 | IGSF11 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.26e-04 | 3.87e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451851 | Colorectum | SER | maintenance of protein location | 26/2897 | 94/18723 | 1.76e-03 | 1.81e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGSF11 | SNV | Missense_Mutation | rs779100034 | c.607N>T | p.Arg203Trp | p.R203W | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
IGSF11 | SNV | Missense_Mutation | c.985N>T | p.His329Tyr | p.H329Y | Q5DX21 | protein_coding | tolerated(0.11) | benign(0.091) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IGSF11 | SNV | Missense_Mutation | c.924N>A | p.Asn308Lys | p.N308K | Q5DX21 | protein_coding | deleterious(0) | possibly_damaging(0.541) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
IGSF11 | insertion | In_Frame_Ins | novel | c.946_947insTTATCTTCTGGTGTGCTCCTGGAAGTGTCTACCCTACATTTGTGT | p.Ala316delinsValIlePheTrpCysAlaProGlySerValTyrProThrPheValSer | p.A316delinsVIFWCAPGSVYPTFVS | Q5DX21 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
IGSF11 | SNV | Missense_Mutation | rs759581949 | c.268N>A | p.Gly90Ser | p.G90S | Q5DX21 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-C5-A1MI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
IGSF11 | SNV | Missense_Mutation | c.1142N>T | p.Ser381Leu | p.S381L | Q5DX21 | protein_coding | deleterious(0.02) | possibly_damaging(0.522) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.481N>C | p.Val161Leu | p.V161L | Q5DX21 | protein_coding | tolerated(0.07) | benign(0.158) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IGSF11 | SNV | Missense_Mutation | c.877N>C | p.Cys293Arg | p.C293R | Q5DX21 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | c.1238N>A | p.Arg413Gln | p.R413Q | Q5DX21 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IGSF11 | SNV | Missense_Mutation | novel | c.1016N>C | p.Ser339Thr | p.S339T | Q5DX21 | protein_coding | tolerated(0.13) | benign(0.034) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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