![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: IGKV4-1 |
Gene summary for IGKV4-1 |
![]() |
Gene information | Species | Human | Gene symbol | IGKV4-1 | Gene ID | 28908 |
Gene name | immunoglobulin kappa variable 4-1 | |
Gene Alias | B3 | |
Cytomap | 2p11.2 | |
Gene Type | other | GO ID | GO:0002250 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28908 | IGKV4-1 | C51 | Human | Oral cavity | OSCC | 3.34e-13 | 6.19e-01 | 0.2674 |
28908 | IGKV4-1 | C57 | Human | Oral cavity | OSCC | 8.37e-12 | 2.03e-01 | 0.1679 |
28908 | IGKV4-1 | C86 | Human | Oral cavity | OSCC | 2.40e-05 | 7.88e-01 | 0.161 |
28908 | IGKV4-1 | LN22 | Human | Oral cavity | OSCC | 4.71e-06 | 4.54e-01 | 0.1733 |
28908 | IGKV4-1 | LP15 | Human | Oral cavity | LP | 1.22e-07 | 6.02e-01 | 0.2174 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGKV4-1 | SNV | Missense_Mutation | rs777621314 | c.269N>A | p.Gly90Asp | p.G90D | P06312 | IG_V_gene | deleterious(0) | probably_damaging(0.993) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | rs758803569 | c.229G>A | p.Ala77Thr | p.A77T | P06312 | IG_V_gene | tolerated(0.05) | possibly_damaging(0.599) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | novel | c.168N>T | p.Lys56Asn | p.K56N | P06312 | IG_V_gene | tolerated(0.27) | benign(0.062) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | rs778305195 | c.137N>A | p.Ser46Asn | p.S46N | P06312 | IG_V_gene | deleterious(0.02) | benign(0.386) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | novel | c.356N>T | p.Ser119Ile | p.S119I | P06312 | IG_V_gene | deleterious(0.03) | benign(0.104) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | novel | c.362N>A | p.Pro121His | p.P121H | P06312 | IG_V_gene | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
IGKV4-1 | SNV | Missense_Mutation | rs758511205 | c.287N>G | p.Asp96Gly | p.D96G | P06312 | IG_V_gene | deleterious(0.02) | probably_damaging(0.94) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | rs374142442 | c.161A>T | p.Asn54Ile | p.N54I | P06312 | IG_V_gene | tolerated(0.07) | possibly_damaging(0.738) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | rs746807080 | c.260G>A | p.Arg87Gln | p.R87Q | P06312 | IG_V_gene | deleterious(0.01) | possibly_damaging(0.522) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
IGKV4-1 | SNV | Missense_Mutation | novel | c.134C>T | p.Ser45Phe | p.S45F | P06312 | IG_V_gene | deleterious(0) | probably_damaging(0.91) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |