|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: IGJ |
Gene summary for IGJ |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IGJ | Gene ID | 3512 |
| Gene name | joining chain of multimeric IgA and IgM | |
| Gene Alias | IGCJ | |
| Cytomap | 4q13.3 | |
| Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | P01591 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3512 | IGJ | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.91e-08 | 1.40e+00 | 0.159 |
| 3512 | IGJ | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 3.83e-03 | 1.05e+00 | 0.156 |
| 3512 | IGJ | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 2.30e-20 | 2.54e+00 | 0.1479 |
| 3512 | IGJ | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 2.50e-18 | 2.26e+00 | 0.1531 |
| 3512 | IGJ | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.53e-03 | 7.84e-01 | 0.1633 |
| 3512 | IGJ | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.27e-04 | 1.01e+00 | 0.1619 |
| 3512 | IGJ | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 2.91e-04 | 1.15e+00 | 0.159 |
| 3512 | IGJ | NAG_1 | Human | Stomach | CSG | 1.27e-07 | 3.16e-01 | -0.3534 |
| 3512 | IGJ | NAG_2 | Human | Stomach | CSG | 1.43e-90 | 1.69e+00 | -0.3324 |
| 3512 | IGJ | NAG_3 | Human | Stomach | CSG | 1.88e-17 | 6.57e-01 | -0.2816 |
| 3512 | IGJ | CAG_1 | Human | Stomach | CAG | 1.24e-67 | 2.06e+00 | -0.3206 |
| 3512 | IGJ | CAG_2 | Human | Stomach | CAG | 1.01e-92 | 1.56e+00 | -0.2831 |
| 3512 | IGJ | CAG_3 | Human | Stomach | CAG | 1.01e-07 | 2.97e-01 | -0.2766 |
| 3512 | IGJ | WIM_2 | Human | Stomach | WIM | 2.97e-30 | 9.26e-01 | 0.1159 |
| 3512 | IGJ | SIM_1 | Human | Stomach | SIM | 3.75e-86 | 1.46e+00 | 0.3573 |
| 3512 | IGJ | SIM_2 | Human | Stomach | SIM | 6.64e-50 | 1.01e+00 | 0.3139 |
| 3512 | IGJ | SIM_4 | Human | Stomach | SIM | 3.26e-59 | 1.26e+00 | 0.2664 |
| 3512 | IGJ | Pt1_Superficial | Human | Stomach | GC | 2.54e-38 | 1.21e+00 | 0.1036 |
| 3512 | IGJ | Pt2_Superficial | Human | Stomach | GC | 1.51e-08 | 7.12e-01 | 0.2977 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |