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Gene: IGHG3 |
Gene summary for IGHG3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IGHG3 | Gene ID | 3502 |
| Gene name | immunoglobulin heavy constant gamma 3 (G3m marker) | |
| Gene Alias | IgG3 | |
| Cytomap | 14q32.33 | |
| Gene Type | other | GO ID | GO:0001775 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3502 | IGHG3 | GSM4909281 | Human | Breast | IDC | 4.12e-17 | 3.04e-01 | 0.21 |
| 3502 | IGHG3 | GSM4909288 | Human | Breast | IDC | 1.38e-05 | 3.79e-01 | 0.0988 |
| 3502 | IGHG3 | GSM4909290 | Human | Breast | IDC | 7.33e-29 | 5.22e-01 | 0.2096 |
| 3502 | IGHG3 | GSM4909291 | Human | Breast | IDC | 1.92e-05 | 2.05e-01 | 0.1753 |
| 3502 | IGHG3 | GSM4909298 | Human | Breast | IDC | 7.43e-04 | 1.17e-01 | 0.1551 |
| 3502 | IGHG3 | GSM4909300 | Human | Breast | IDC | 1.32e-05 | 1.97e-01 | 0.0334 |
| 3502 | IGHG3 | GSM4909304 | Human | Breast | IDC | 7.01e-03 | 9.70e-02 | 0.1636 |
| 3502 | IGHG3 | GSM4909305 | Human | Breast | IDC | 3.29e-02 | 1.14e-01 | 0.0436 |
| 3502 | IGHG3 | GSM4909308 | Human | Breast | IDC | 1.95e-10 | 2.17e-01 | 0.158 |
| 3502 | IGHG3 | GSM4909317 | Human | Breast | IDC | 1.29e-32 | 5.26e-01 | 0.1355 |
| 3502 | IGHG3 | GSM4909318 | Human | Breast | IDC | 8.25e-03 | 4.11e-01 | 0.2031 |
| 3502 | IGHG3 | M1 | Human | Breast | IDC | 3.82e-17 | 3.90e-01 | 0.1577 |
| 3502 | IGHG3 | CA_HPV_1 | Human | Cervix | CC | 1.03e-31 | -9.54e-01 | 0.0264 |
| 3502 | IGHG3 | CA_HPV_2 | Human | Cervix | CC | 1.29e-47 | -1.05e+00 | 0.0391 |
| 3502 | IGHG3 | CA_HPV_3 | Human | Cervix | CC | 1.05e-46 | -1.05e+00 | 0.0414 |
| 3502 | IGHG3 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 3.44e-21 | -8.82e-01 | 0.0116 |
| 3502 | IGHG3 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.30e-14 | -5.12e-01 | 0.0208 |
| 3502 | IGHG3 | N_HPV_1 | Human | Cervix | N_HPV | 3.54e-21 | -8.85e-01 | 0.0079 |
| 3502 | IGHG3 | N_HPV_2 | Human | Cervix | N_HPV | 7.47e-22 | -8.38e-01 | -0.0131 |
| 3502 | IGHG3 | CCI_1 | Human | Cervix | CC | 2.33e-14 | -1.05e+00 | 0.528 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000189511 | Breast | IDC | retina homeostasis | 15/1434 | 79/18723 | 8.62e-04 | 1.00e-02 | 15 |
| GO:00069596 | Breast | IDC | humoral immune response | 40/1434 | 317/18723 | 1.25e-03 | 1.33e-02 | 40 |
| GO:000189413 | Breast | IDC | tissue homeostasis | 34/1434 | 268/18723 | 2.54e-03 | 2.28e-02 | 34 |
| GO:00512515 | Breast | IDC | positive regulation of lymphocyte activation | 43/1434 | 362/18723 | 2.72e-03 | 2.41e-02 | 43 |
| GO:00022532 | Breast | IDC | activation of immune response | 43/1434 | 375/18723 | 5.16e-03 | 3.84e-02 | 43 |
| GO:00026966 | Breast | IDC | positive regulation of leukocyte activation | 46/1434 | 409/18723 | 5.60e-03 | 4.07e-02 | 46 |
| GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
| GO:00018949 | Cervix | CC | tissue homeostasis | 57/2311 | 268/18723 | 2.43e-05 | 4.21e-04 | 57 |
| GO:00602498 | Cervix | CC | anatomical structure homeostasis | 63/2311 | 314/18723 | 6.03e-05 | 8.68e-04 | 63 |
| GO:00022533 | Cervix | CC | activation of immune response | 72/2311 | 375/18723 | 8.26e-05 | 1.11e-03 | 72 |
| GO:0002768 | Cervix | CC | immune response-regulating cell surface receptor signaling pathway | 59/2311 | 315/18723 | 6.64e-04 | 6.11e-03 | 59 |
| GO:00026967 | Cervix | CC | positive regulation of leukocyte activation | 72/2311 | 409/18723 | 1.13e-03 | 9.31e-03 | 72 |
| GO:00512516 | Cervix | CC | positive regulation of lymphocyte activation | 65/2311 | 362/18723 | 1.15e-03 | 9.39e-03 | 65 |
| GO:00508676 | Cervix | CC | positive regulation of cell activation | 73/2311 | 420/18723 | 1.50e-03 | 1.16e-02 | 73 |
| GO:00018957 | Cervix | CC | retina homeostasis | 19/2311 | 79/18723 | 2.94e-03 | 1.94e-02 | 19 |
| GO:00024603 | Cervix | CC | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 62/2311 | 356/18723 | 3.09e-03 | 2.03e-02 | 62 |
| GO:0002443 | Cervix | CC | leukocyte mediated immunity | 73/2311 | 440/18723 | 5.01e-03 | 2.98e-02 | 73 |
| GO:0006909 | Cervix | CC | phagocytosis | 53/2311 | 308/18723 | 7.49e-03 | 4.01e-02 | 53 |
| GO:00069597 | Cervix | CC | humoral immune response | 54/2311 | 317/18723 | 8.57e-03 | 4.42e-02 | 54 |
| GO:00103243 | Cervix | CC | membrane invagination | 28/2311 | 144/18723 | 9.50e-03 | 4.72e-02 | 28 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| IGHG3 | SNV | Missense_Mutation | novel | c.269N>G | p.Ser90Arg | p.S90R | IG_C_gene | deleterious(0) | probably_damaging(0.985) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
| IGHG3 | SNV | Missense_Mutation | rs765771132 | c.132N>A | p.Ala45Thr | p.A45T | IG_C_gene | tolerated(0.19) | benign(0.125) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| IGHG3 | SNV | Missense_Mutation | novel | c.357N>G | p.Cys120Gly | p.C120G | IG_C_gene | tolerated(0.39) | benign(0) | TCGA-AO-A1KP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD | |
| IGHG3 | SNV | Missense_Mutation | novel | c.280N>A | p.Val94Glu | p.V94E | IG_C_gene | deleterious(0) | probably_damaging(0.949) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGHG3 | SNV | Missense_Mutation | rs752126457 | c.597N>C | p.Asp200His | p.D200H | IG_C_gene | tolerated(0.05) | benign(0.028) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGHG3 | SNV | Missense_Mutation | rs759037989 | c.561G>A | p.Glu188Lys | p.E188K | IG_C_gene | tolerated(0.99) | benign(0.11) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
| IGHG3 | SNV | Missense_Mutation | novel | c.19N>T | p.Ser7Leu | p.S7L | IG_C_gene | tolerated(0.08) | benign(0.146) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGHG3 | SNV | Missense_Mutation | rs748081229 | c.337G>A | p.Arg113Gln | p.R113Q | IG_C_gene | tolerated(0.59) | benign(0.009) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| IGHG3 | SNV | Missense_Mutation | novel | c.195N>T | p.Ser66Cys | p.S66C | IG_C_gene | deleterious(0) | probably_damaging(0.988) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGHG3 | SNV | Missense_Mutation | novel | c.828N>G | p.Gln277Glu | p.Q277E | IG_C_gene | tolerated(0.33) | benign(0.037) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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