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Gene: IGFL2 |
Gene summary for IGFL2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IGFL2 | Gene ID | 147920 |
| Gene name | IGF like family member 2 | |
| Gene Alias | UNQ645 | |
| Cytomap | 19q13.32 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6UWQ7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 147920 | IGFL2 | C04 | Human | Oral cavity | OSCC | 3.25e-08 | 3.81e-01 | 0.2633 |
| 147920 | IGFL2 | C30 | Human | Oral cavity | OSCC | 2.19e-41 | 2.96e+00 | 0.3055 |
| 147920 | IGFL2 | SYSMH3 | Human | Oral cavity | OSCC | 2.29e-20 | 9.26e-01 | 0.2442 |
| 147920 | IGFL2 | SYSMH5 | Human | Oral cavity | OSCC | 4.29e-04 | 1.58e-01 | 0.0647 |
| 147920 | IGFL2 | SYSMH6 | Human | Oral cavity | OSCC | 1.66e-02 | 5.27e-01 | 0.1275 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| IGFL2 | SNV | Missense_Mutation | c.179N>T | p.Glu60Val | p.E60V | Q6UWQ7 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGFL2 | SNV | Missense_Mutation | rs866490588 | c.298N>A | p.Asp100Asn | p.D100N | Q6UWQ7 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| IGFL2 | SNV | Missense_Mutation | novel | c.180N>T | p.Glu60Asp | p.E60D | Q6UWQ7 | protein_coding | deleterious(0.03) | benign(0.36) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| IGFL2 | SNV | Missense_Mutation | rs544005376 | c.382N>T | p.Arg128Cys | p.R128C | Q6UWQ7 | protein_coding | tolerated(0.17) | benign(0) | TCGA-A5-A1OG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD |
| IGFL2 | SNV | Missense_Mutation | c.229N>C | p.Cys77Arg | p.C77R | Q6UWQ7 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| IGFL2 | SNV | Missense_Mutation | rs544005376 | c.382N>T | p.Arg128Cys | p.R128C | Q6UWQ7 | protein_coding | tolerated(0.17) | benign(0) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| IGFL2 | SNV | Missense_Mutation | novel | c.176N>C | p.Leu59Ser | p.L59S | Q6UWQ7 | protein_coding | tolerated(0.13) | benign(0.146) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| IGFL2 | SNV | Missense_Mutation | rs866490588 | c.298N>A | p.Asp100Asn | p.D100N | Q6UWQ7 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| IGFL2 | insertion | Frame_Shift_Ins | novel | c.355_356insATCAGGAGCCC | p.Ile119AsnfsTer20 | p.I119Nfs*20 | Q6UWQ7 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
| IGFL2 | SNV | Missense_Mutation | rs754195953 | c.199N>A | p.Ala67Thr | p.A67T | Q6UWQ7 | protein_coding | tolerated(1) | benign(0.007) | TCGA-DD-AAE0-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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