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Gene: IGFBP1 |
Gene summary for IGFBP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IGFBP1 | Gene ID | 3484 |
| Gene name | insulin like growth factor binding protein 1 | |
| Gene Alias | AFBP | |
| Cytomap | 7p12.3 | |
| Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P08833 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3484 | IGFBP1 | NAFLD1 | Human | Liver | NAFLD | 6.54e-07 | 1.05e+00 | -0.04 |
| 3484 | IGFBP1 | S41 | Human | Liver | Cirrhotic | 2.14e-10 | 9.90e-01 | -0.0343 |
| 3484 | IGFBP1 | S43 | Human | Liver | Cirrhotic | 1.74e-08 | 1.34e-01 | -0.0187 |
| 3484 | IGFBP1 | S44 | Human | Liver | HCC | 2.12e-09 | 1.12e+00 | -0.0083 |
| 3484 | IGFBP1 | HCC1_Meng | Human | Liver | HCC | 4.05e-36 | 2.99e-01 | 0.0246 |
| 3484 | IGFBP1 | HCC2_Meng | Human | Liver | HCC | 9.48e-12 | -3.75e-01 | 0.0107 |
| 3484 | IGFBP1 | cirrhotic1 | Human | Liver | Cirrhotic | 4.09e-02 | -2.16e-01 | 0.0202 |
| 3484 | IGFBP1 | cirrhotic3 | Human | Liver | Cirrhotic | 2.58e-02 | -3.37e-01 | 0.0215 |
| 3484 | IGFBP1 | HCC1 | Human | Liver | HCC | 3.80e-14 | 5.04e+00 | 0.5336 |
| 3484 | IGFBP1 | HCC2 | Human | Liver | HCC | 1.35e-10 | 4.89e+00 | 0.5341 |
| 3484 | IGFBP1 | Pt13.b | Human | Liver | HCC | 1.11e-14 | 1.94e-01 | 0.0251 |
| 3484 | IGFBP1 | S014 | Human | Liver | HCC | 4.39e-13 | 3.73e+00 | 0.2254 |
| 3484 | IGFBP1 | S015 | Human | Liver | HCC | 2.41e-23 | 4.50e+00 | 0.2375 |
| 3484 | IGFBP1 | S016 | Human | Liver | HCC | 8.08e-29 | 3.59e+00 | 0.2243 |
| 3484 | IGFBP1 | S027 | Human | Liver | HCC | 1.04e-19 | 4.38e+00 | 0.2446 |
| 3484 | IGFBP1 | S028 | Human | Liver | HCC | 5.94e-14 | 2.50e+00 | 0.2503 |
| 3484 | IGFBP1 | S029 | Human | Liver | HCC | 4.24e-32 | 5.39e+00 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00713755 | Liver | NAFLD | cellular response to peptide hormone stimulus | 65/1882 | 290/18723 | 3.95e-10 | 9.62e-08 | 65 |
| GO:19016536 | Liver | NAFLD | cellular response to peptide | 71/1882 | 359/18723 | 1.82e-08 | 2.09e-06 | 71 |
| GO:00328695 | Liver | NAFLD | cellular response to insulin stimulus | 47/1882 | 203/18723 | 3.60e-08 | 3.63e-06 | 47 |
| GO:00434346 | Liver | NAFLD | response to peptide hormone | 76/1882 | 414/18723 | 1.51e-07 | 1.09e-05 | 76 |
| GO:00160495 | Liver | NAFLD | cell growth | 85/1882 | 482/18723 | 1.75e-07 | 1.25e-05 | 85 |
| GO:00328685 | Liver | NAFLD | response to insulin | 53/1882 | 264/18723 | 6.99e-07 | 3.95e-05 | 53 |
| GO:00160555 | Liver | NAFLD | Wnt signaling pathway | 74/1882 | 444/18723 | 8.98e-06 | 2.96e-04 | 74 |
| GO:01987385 | Liver | NAFLD | cell-cell signaling by wnt | 74/1882 | 446/18723 | 1.05e-05 | 3.33e-04 | 74 |
| GO:00082863 | Liver | NAFLD | insulin receptor signaling pathway | 27/1882 | 116/18723 | 2.50e-05 | 6.76e-04 | 27 |
| GO:00301115 | Liver | NAFLD | regulation of Wnt signaling pathway | 57/1882 | 328/18723 | 2.79e-05 | 7.46e-04 | 57 |
| GO:00608285 | Liver | NAFLD | regulation of canonical Wnt signaling pathway | 44/1882 | 253/18723 | 2.14e-04 | 3.68e-03 | 44 |
| GO:00600705 | Liver | NAFLD | canonical Wnt signaling pathway | 50/1882 | 303/18723 | 3.08e-04 | 4.83e-03 | 50 |
| GO:00015585 | Liver | NAFLD | regulation of cell growth | 63/1882 | 414/18723 | 5.50e-04 | 7.46e-03 | 63 |
| GO:00310993 | Liver | NAFLD | regeneration | 35/1882 | 198/18723 | 6.67e-04 | 8.61e-03 | 35 |
| GO:00075687 | Liver | NAFLD | aging | 53/1882 | 339/18723 | 7.78e-04 | 9.77e-03 | 53 |
| GO:00480091 | Liver | NAFLD | insulin-like growth factor receptor signaling pathway | 10/1882 | 37/18723 | 2.82e-03 | 2.56e-02 | 10 |
| GO:00459275 | Liver | NAFLD | positive regulation of growth | 40/1882 | 259/18723 | 4.00e-03 | 3.35e-02 | 40 |
| GO:00303075 | Liver | NAFLD | positive regulation of cell growth | 28/1882 | 166/18723 | 4.35e-03 | 3.57e-02 | 28 |
| GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
| GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| IGFBP1 | insertion | Nonsense_Mutation | novel | c.766_767insTGCTTCACAGGCAATGAACAGTGGGGCACACACGAGAC | p.Asn256MetfsTer6 | p.N256Mfs*6 | P08833 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
| IGFBP1 | SNV | Missense_Mutation | rs747950009 | c.634T>C | p.Tyr212His | p.Y212H | P08833 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3506-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| IGFBP1 | SNV | Missense_Mutation | c.497N>C | p.Val166Ala | p.V166A | P08833 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| IGFBP1 | SNV | Missense_Mutation | rs369196046 | c.530N>A | p.Arg177Gln | p.R177Q | P08833 | protein_coding | tolerated(1) | benign(0.03) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| IGFBP1 | SNV | Missense_Mutation | c.668N>T | p.Gly223Val | p.G223V | P08833 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| IGFBP1 | SNV | Missense_Mutation | novel | c.774N>C | p.Gln258His | p.Q258H | P08833 | protein_coding | tolerated(0.08) | benign(0.024) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| IGFBP1 | SNV | Missense_Mutation | rs566229997 | c.460N>A | p.Ala154Thr | p.A154T | P08833 | protein_coding | deleterious(0.02) | possibly_damaging(0.824) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| IGFBP1 | SNV | Missense_Mutation | rs769609357 | c.641G>A | p.Ser214Asn | p.S214N | P08833 | protein_coding | deleterious(0.01) | probably_damaging(0.943) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| IGFBP1 | SNV | Missense_Mutation | c.512N>T | p.Lys171Ile | p.K171I | P08833 | protein_coding | deleterious(0.05) | possibly_damaging(0.746) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGFBP1 | SNV | Missense_Mutation | rs369196046 | c.530N>A | p.Arg177Gln | p.R177Q | P08833 | protein_coding | tolerated(1) | benign(0.03) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 3484 | IGFBP1 | DRUGGABLE GENOME | ORAL CONTRACEPTIVE | 8530593 | ||
| 3484 | IGFBP1 | DRUGGABLE GENOME | DEXAMETHASONE | DEXAMETHASONE | 7683312,1714534 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | STZ | STREPTOZOCIN | 1713293,7589849 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | ETHANOL | ALCOHOL | 11894976 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | OCTREOTIDE | OCTREOTIDE | 9512248,7525123 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | BUSERELIN | BUSERELIN | 7544746 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | SANDOSTATIN | SANDOSTATIN | 9420847 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | RAPAMYCIN | SIROLIMUS | 11942857 | |
| 3484 | IGFBP1 | DRUGGABLE GENOME | PMA | 8557761 | ||
| 3484 | IGFBP1 | DRUGGABLE GENOME | HORMONES | 8619542,8567796 |
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