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Gene: IFT74 |
Gene summary for IFT74 |
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Gene information | Species | Human | Gene symbol | IFT74 | Gene ID | 80173 |
Gene name | intraflagellar transport 74 | |
Gene Alias | BBS22 | |
Cytomap | 9p21.2 | |
Gene Type | protein-coding | GO ID | GO:0002064 | UniProtAcc | Q96LB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80173 | IFT74 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.23e-19 | 7.80e-01 | -0.1954 |
80173 | IFT74 | A015-C-203 | Human | Colorectum | FAP | 7.33e-13 | -1.21e-01 | -0.1294 |
80173 | IFT74 | A002-C-201 | Human | Colorectum | FAP | 3.15e-03 | -9.19e-02 | 0.0324 |
80173 | IFT74 | A001-C-108 | Human | Colorectum | FAP | 1.28e-07 | -9.44e-02 | -0.0272 |
80173 | IFT74 | A002-C-205 | Human | Colorectum | FAP | 3.63e-08 | -1.67e-01 | -0.1236 |
80173 | IFT74 | A015-C-006 | Human | Colorectum | FAP | 1.27e-05 | -2.28e-01 | -0.0994 |
80173 | IFT74 | A015-C-106 | Human | Colorectum | FAP | 1.90e-02 | -2.90e-02 | -0.0511 |
80173 | IFT74 | A002-C-114 | Human | Colorectum | FAP | 8.85e-08 | -2.42e-01 | -0.1561 |
80173 | IFT74 | A015-C-104 | Human | Colorectum | FAP | 4.23e-16 | -1.33e-01 | -0.1899 |
80173 | IFT74 | A001-C-014 | Human | Colorectum | FAP | 7.65e-07 | -1.89e-01 | 0.0135 |
80173 | IFT74 | A002-C-016 | Human | Colorectum | FAP | 4.69e-12 | -1.77e-01 | 0.0521 |
80173 | IFT74 | A015-C-002 | Human | Colorectum | FAP | 2.36e-03 | -1.45e-01 | -0.0763 |
80173 | IFT74 | A002-C-116 | Human | Colorectum | FAP | 1.81e-15 | -2.19e-01 | -0.0452 |
80173 | IFT74 | A014-C-008 | Human | Colorectum | FAP | 1.84e-05 | -3.05e-01 | -0.191 |
80173 | IFT74 | A018-E-020 | Human | Colorectum | FAP | 7.00e-08 | -1.82e-01 | -0.2034 |
80173 | IFT74 | F034 | Human | Colorectum | FAP | 2.70e-07 | -9.81e-02 | -0.0665 |
80173 | IFT74 | CRC-3-11773 | Human | Colorectum | CRC | 2.27e-03 | -1.07e-01 | 0.2564 |
80173 | IFT74 | LZE4T | Human | Esophagus | ESCC | 3.77e-07 | 2.52e-01 | 0.0811 |
80173 | IFT74 | LZE7T | Human | Esophagus | ESCC | 8.95e-04 | 2.46e-01 | 0.0667 |
80173 | IFT74 | LZE8T | Human | Esophagus | ESCC | 9.25e-05 | 1.52e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
GO:00020644 | Colorectum | FAP | epithelial cell development | 62/2622 | 220/18723 | 2.74e-08 | 2.54e-06 | 62 |
GO:00457854 | Colorectum | FAP | positive regulation of cell adhesion | 92/2622 | 437/18723 | 3.09e-05 | 7.04e-04 | 92 |
GO:00307053 | Colorectum | FAP | cytoskeleton-dependent intracellular transport | 47/2622 | 195/18723 | 1.06e-04 | 1.76e-03 | 47 |
GO:0043588 | Colorectum | FAP | skin development | 58/2622 | 263/18723 | 2.44e-04 | 3.39e-03 | 58 |
GO:00085441 | Colorectum | FAP | epidermis development | 66/2622 | 324/18723 | 9.63e-04 | 9.51e-03 | 66 |
GO:00506732 | Colorectum | FAP | epithelial cell proliferation | 84/2622 | 437/18723 | 1.39e-03 | 1.25e-02 | 84 |
GO:00072191 | Colorectum | FAP | Notch signaling pathway | 38/2622 | 172/18723 | 2.56e-03 | 2.01e-02 | 38 |
GO:00099132 | Colorectum | FAP | epidermal cell differentiation | 42/2622 | 202/18723 | 5.08e-03 | 3.37e-02 | 42 |
GO:0003334 | Colorectum | FAP | keratinocyte development | 6/2622 | 13/18723 | 5.32e-03 | 3.49e-02 | 6 |
GO:00506781 | Colorectum | FAP | regulation of epithelial cell proliferation | 71/2622 | 381/18723 | 6.67e-03 | 4.12e-02 | 71 |
GO:00020645 | Colorectum | CRC | epithelial cell development | 55/2078 | 220/18723 | 4.63e-09 | 1.16e-06 | 55 |
GO:00307054 | Colorectum | CRC | cytoskeleton-dependent intracellular transport | 45/2078 | 195/18723 | 1.29e-06 | 7.21e-05 | 45 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFT74 | SNV | Missense_Mutation | c.491N>T | p.Thr164Ile | p.T164I | Q96LB3 | protein_coding | tolerated(0.06) | benign(0.377) | TCGA-D8-A1JT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
IFT74 | insertion | Frame_Shift_Ins | novel | c.248_249insTTTTCACATAGTTTTTAAAATTTTTATTTTTGTCTATATTTTTT | p.Thr84PhefsTer15 | p.T84Ffs*15 | Q96LB3 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
IFT74 | SNV | Missense_Mutation | c.1705G>C | p.Glu569Gln | p.E569Q | Q96LB3 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IFT74 | insertion | Frame_Shift_Ins | novel | c.1041_1042insAT | p.Glu348MetfsTer8 | p.E348Mfs*8 | Q96LB3 | protein_coding | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
IFT74 | insertion | Frame_Shift_Ins | novel | c.1042_1043insGATTTAA | p.Glu348GlyfsTer8 | p.E348Gfs*8 | Q96LB3 | protein_coding | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
IFT74 | SNV | Missense_Mutation | novel | c.743A>G | p.Gln248Arg | p.Q248R | Q96LB3 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
IFT74 | SNV | Missense_Mutation | c.404G>T | p.Arg135Met | p.R135M | Q96LB3 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFT74 | SNV | Missense_Mutation | c.1489N>G | p.Lys497Glu | p.K497E | Q96LB3 | protein_coding | tolerated(0.06) | benign(0.231) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
IFT74 | SNV | Missense_Mutation | novel | c.1175N>T | p.Asn392Ile | p.N392I | Q96LB3 | protein_coding | deleterious(0.03) | benign(0.144) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IFT74 | SNV | Missense_Mutation | c.1514G>A | p.Arg505Lys | p.R505K | Q96LB3 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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