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Gene: IFRD2 |
Gene summary for IFRD2 |
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Gene information | Species | Human | Gene symbol | IFRD2 | Gene ID | 7866 |
Gene name | interferon related developmental regulator 2 | |
Gene Alias | IFNRP | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q12894 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7866 | IFRD2 | LZE7T | Human | Esophagus | ESCC | 1.64e-04 | 2.77e-01 | 0.0667 |
7866 | IFRD2 | LZE24T | Human | Esophagus | ESCC | 9.55e-14 | 3.86e-01 | 0.0596 |
7866 | IFRD2 | LZE6T | Human | Esophagus | ESCC | 3.73e-02 | 6.62e-02 | 0.0845 |
7866 | IFRD2 | P1T-E | Human | Esophagus | ESCC | 1.77e-07 | 4.02e-01 | 0.0875 |
7866 | IFRD2 | P2T-E | Human | Esophagus | ESCC | 5.24e-29 | 2.41e-01 | 0.1177 |
7866 | IFRD2 | P4T-E | Human | Esophagus | ESCC | 2.71e-21 | 6.96e-01 | 0.1323 |
7866 | IFRD2 | P5T-E | Human | Esophagus | ESCC | 3.64e-16 | 4.77e-01 | 0.1327 |
7866 | IFRD2 | P8T-E | Human | Esophagus | ESCC | 3.65e-23 | 1.83e-01 | 0.0889 |
7866 | IFRD2 | P9T-E | Human | Esophagus | ESCC | 1.30e-17 | 4.68e-01 | 0.1131 |
7866 | IFRD2 | P10T-E | Human | Esophagus | ESCC | 6.31e-21 | 3.62e-01 | 0.116 |
7866 | IFRD2 | P11T-E | Human | Esophagus | ESCC | 2.22e-11 | 4.77e-01 | 0.1426 |
7866 | IFRD2 | P12T-E | Human | Esophagus | ESCC | 6.10e-26 | 4.27e-01 | 0.1122 |
7866 | IFRD2 | P15T-E | Human | Esophagus | ESCC | 2.37e-12 | 2.47e-01 | 0.1149 |
7866 | IFRD2 | P16T-E | Human | Esophagus | ESCC | 2.84e-21 | 4.74e-01 | 0.1153 |
7866 | IFRD2 | P17T-E | Human | Esophagus | ESCC | 1.51e-04 | 5.38e-01 | 0.1278 |
7866 | IFRD2 | P19T-E | Human | Esophagus | ESCC | 4.27e-07 | 9.22e-01 | 0.1662 |
7866 | IFRD2 | P20T-E | Human | Esophagus | ESCC | 3.93e-09 | 2.74e-01 | 0.1124 |
7866 | IFRD2 | P21T-E | Human | Esophagus | ESCC | 5.16e-40 | 9.24e-01 | 0.1617 |
7866 | IFRD2 | P22T-E | Human | Esophagus | ESCC | 8.42e-20 | 3.44e-01 | 0.1236 |
7866 | IFRD2 | P23T-E | Human | Esophagus | ESCC | 9.05e-25 | 6.90e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFRD2 | SNV | Missense_Mutation | c.760N>T | p.Gly254Cys | p.G254C | Q12894 | protein_coding | tolerated(1) | benign(0.023) | TCGA-D8-A1XA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IFRD2 | SNV | Missense_Mutation | rs374366991 | c.1198N>A | p.Val400Met | p.V400M | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
IFRD2 | SNV | Missense_Mutation | rs782492356 | c.1174C>T | p.Arg392Cys | p.R392C | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IFRD2 | SNV | Missense_Mutation | c.1036N>A | p.Glu346Lys | p.E346K | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IFRD2 | SNV | Missense_Mutation | c.1255G>C | p.Glu419Gln | p.E419Q | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IFRD2 | SNV | Missense_Mutation | novel | c.386N>G | p.Asp129Gly | p.D129G | Q12894 | protein_coding | deleterious(0.01) | possibly_damaging(0.589) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
IFRD2 | SNV | Missense_Mutation | rs782161246 | c.1361G>A | p.Arg454His | p.R454H | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
IFRD2 | SNV | Missense_Mutation | rs369995042 | c.1484N>A | p.Arg495Gln | p.R495Q | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | novel | c.580N>T | p.Gly194Trp | p.G194W | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | c.1426N>T | p.Pro476Ser | p.P476S | Q12894 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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