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Gene: HSPD1 |
Gene summary for HSPD1 |
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Gene information | Species | Human | Gene symbol | HSPD1 | Gene ID | 3329 |
Gene name | heat shock protein family D (Hsp60) member 1 | |
Gene Alias | CPN60 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A024R3X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3329 | HSPD1 | GSM4909277 | Human | Breast | Precancer | 1.18e-10 | 7.81e-01 | 0.0177 |
3329 | HSPD1 | GSM4909282 | Human | Breast | IDC | 4.45e-03 | -3.90e-01 | -0.0288 |
3329 | HSPD1 | GSM4909285 | Human | Breast | IDC | 1.03e-08 | 2.95e-01 | 0.21 |
3329 | HSPD1 | GSM4909286 | Human | Breast | IDC | 7.69e-12 | -3.01e-01 | 0.1081 |
3329 | HSPD1 | GSM4909293 | Human | Breast | IDC | 5.99e-07 | -7.90e-02 | 0.1581 |
3329 | HSPD1 | GSM4909294 | Human | Breast | IDC | 1.78e-02 | 4.15e-02 | 0.2022 |
3329 | HSPD1 | GSM4909296 | Human | Breast | IDC | 3.49e-11 | -4.71e-01 | 0.1524 |
3329 | HSPD1 | GSM4909297 | Human | Breast | IDC | 5.78e-17 | -3.79e-01 | 0.1517 |
3329 | HSPD1 | GSM4909298 | Human | Breast | IDC | 4.14e-13 | -5.27e-01 | 0.1551 |
3329 | HSPD1 | GSM4909299 | Human | Breast | IDC | 6.74e-07 | -3.67e-01 | 0.035 |
3329 | HSPD1 | GSM4909300 | Human | Breast | IDC | 3.31e-02 | -4.32e-01 | 0.0334 |
3329 | HSPD1 | GSM4909301 | Human | Breast | IDC | 2.22e-08 | -4.67e-01 | 0.1577 |
3329 | HSPD1 | GSM4909302 | Human | Breast | IDC | 2.92e-10 | -5.04e-01 | 0.1545 |
3329 | HSPD1 | GSM4909306 | Human | Breast | IDC | 1.67e-05 | -3.93e-01 | 0.1564 |
3329 | HSPD1 | GSM4909307 | Human | Breast | IDC | 4.74e-13 | -5.50e-01 | 0.1569 |
3329 | HSPD1 | GSM4909308 | Human | Breast | IDC | 7.15e-04 | -2.24e-01 | 0.158 |
3329 | HSPD1 | GSM4909309 | Human | Breast | IDC | 2.12e-17 | -6.48e-01 | 0.0483 |
3329 | HSPD1 | GSM4909311 | Human | Breast | IDC | 1.07e-41 | -8.00e-01 | 0.1534 |
3329 | HSPD1 | GSM4909312 | Human | Breast | IDC | 1.11e-08 | -3.93e-01 | 0.1552 |
3329 | HSPD1 | GSM4909313 | Human | Breast | IDC | 2.09e-18 | -6.72e-01 | 0.0391 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00064588 | Breast | Precancer | 'de novo' protein folding | 16/1080 | 43/18723 | 8.14e-10 | 6.92e-08 | 16 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:00069869 | Breast | Precancer | response to unfolded protein | 28/1080 | 137/18723 | 3.81e-09 | 3.00e-07 | 28 |
GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
GO:00359669 | Breast | Precancer | response to topologically incorrect protein | 29/1080 | 159/18723 | 3.00e-08 | 1.89e-06 | 29 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513414 | Breast | Precancer | Legionellosis | 19/684 | 57/8465 | 4.62e-08 | 9.12e-07 | 6.98e-07 | 19 |
hsa0541718 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0513415 | Breast | Precancer | Legionellosis | 19/684 | 57/8465 | 4.62e-08 | 9.12e-07 | 6.98e-07 | 19 |
hsa0541719 | Breast | Precancer | Lipid and atherosclerosis | 37/684 | 215/8465 | 7.64e-06 | 9.29e-05 | 7.12e-05 | 37 |
hsa0513422 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0494014 | Breast | IDC | Type I diabetes mellitus | 12/867 | 43/8465 | 9.40e-04 | 7.28e-03 | 5.44e-03 | 12 |
hsa0541724 | Breast | IDC | Lipid and atherosclerosis | 35/867 | 215/8465 | 3.67e-03 | 2.29e-02 | 1.71e-02 | 35 |
hsa0301821 | Breast | IDC | RNA degradation | 16/867 | 79/8465 | 5.65e-03 | 3.13e-02 | 2.34e-02 | 16 |
hsa0513432 | Breast | IDC | Legionellosis | 19/867 | 57/8465 | 1.89e-06 | 3.07e-05 | 2.29e-05 | 19 |
hsa0494015 | Breast | IDC | Type I diabetes mellitus | 12/867 | 43/8465 | 9.40e-04 | 7.28e-03 | 5.44e-03 | 12 |
hsa0541734 | Breast | IDC | Lipid and atherosclerosis | 35/867 | 215/8465 | 3.67e-03 | 2.29e-02 | 1.71e-02 | 35 |
hsa0301831 | Breast | IDC | RNA degradation | 16/867 | 79/8465 | 5.65e-03 | 3.13e-02 | 2.34e-02 | 16 |
hsa0513441 | Breast | DCIS | Legionellosis | 19/846 | 57/8465 | 1.30e-06 | 2.10e-05 | 1.55e-05 | 19 |
hsa030184 | Breast | DCIS | RNA degradation | 16/846 | 79/8465 | 4.45e-03 | 2.46e-02 | 1.82e-02 | 16 |
hsa0541744 | Breast | DCIS | Lipid and atherosclerosis | 34/846 | 215/8465 | 4.50e-03 | 2.46e-02 | 1.82e-02 | 34 |
hsa0513451 | Breast | DCIS | Legionellosis | 19/846 | 57/8465 | 1.30e-06 | 2.10e-05 | 1.55e-05 | 19 |
hsa030185 | Breast | DCIS | RNA degradation | 16/846 | 79/8465 | 4.45e-03 | 2.46e-02 | 1.82e-02 | 16 |
hsa0541754 | Breast | DCIS | Lipid and atherosclerosis | 34/846 | 215/8465 | 4.50e-03 | 2.46e-02 | 1.82e-02 | 34 |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa0494016 | Cervix | CC | Type I diabetes mellitus | 17/1267 | 43/8465 | 7.47e-05 | 5.04e-04 | 2.98e-04 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPD1 | SNV | Missense_Mutation | c.829N>A | p.Asp277Asn | p.D277N | P10809 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSPD1 | SNV | Missense_Mutation | c.390N>T | p.Lys130Asn | p.K130N | P10809 | protein_coding | tolerated(0.63) | benign(0.007) | TCGA-AR-A0TW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD | |
HSPD1 | SNV | Missense_Mutation | c.1483N>C | p.Met495Leu | p.M495L | P10809 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | |
HSPD1 | SNV | Missense_Mutation | c.1084G>T | p.Gly362Cys | p.G362C | P10809 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSPD1 | SNV | Missense_Mutation | c.460G>A | p.Glu154Lys | p.E154K | P10809 | protein_coding | tolerated(0.2) | benign(0.145) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
HSPD1 | SNV | Missense_Mutation | c.764N>G | p.Gln255Arg | p.Q255R | P10809 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
HSPD1 | SNV | Missense_Mutation | rs768557320 | c.1108N>T | p.Arg370Cys | p.R370C | P10809 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HSPD1 | SNV | Missense_Mutation | novel | c.115N>G | p.Leu39Val | p.L39V | P10809 | protein_coding | tolerated(0.22) | benign(0.206) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HSPD1 | SNV | Missense_Mutation | c.517N>G | p.Thr173Ala | p.T173A | P10809 | protein_coding | deleterious(0.01) | benign(0.099) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSPD1 | SNV | Missense_Mutation | rs751104797 | c.1178G>A | p.Arg393Gln | p.R393Q | P10809 | protein_coding | deleterious(0.02) | possibly_damaging(0.634) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3329 | HSPD1 | DRUGGABLE GENOME, ENZYME, CELL SURFACE | CETRORELIX | CETRORELIX | 9805247 | |
3329 | HSPD1 | DRUGGABLE GENOME, ENZYME, CELL SURFACE | ATORVASTATIN | ATORVASTATIN | 15678257 | |
3329 | HSPD1 | DRUGGABLE GENOME, ENZYME, CELL SURFACE | DiaPep-277 | DIAPEP-277 |
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