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Gene: HSPBAP1 |
Gene summary for HSPBAP1 |
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Gene information | Species | Human | Gene symbol | HSPBAP1 | Gene ID | 79663 |
Gene name | HSPB1 associated protein 1 | |
Gene Alias | PASS1 | |
Cytomap | 3q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96EW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79663 | HSPBAP1 | CCI_2 | Human | Cervix | CC | 2.35e-10 | 7.90e-01 | 0.5249 |
79663 | HSPBAP1 | CCI_3 | Human | Cervix | CC | 1.50e-15 | 6.19e-01 | 0.516 |
79663 | HSPBAP1 | LZE2T | Human | Esophagus | ESCC | 6.35e-04 | 4.37e-01 | 0.082 |
79663 | HSPBAP1 | LZE4T | Human | Esophagus | ESCC | 4.27e-09 | 2.61e-01 | 0.0811 |
79663 | HSPBAP1 | LZE7T | Human | Esophagus | ESCC | 2.74e-07 | 4.02e-01 | 0.0667 |
79663 | HSPBAP1 | LZE21D1 | Human | Esophagus | HGIN | 6.00e-03 | 2.34e-01 | 0.0632 |
79663 | HSPBAP1 | LZE24T | Human | Esophagus | ESCC | 2.95e-15 | 3.44e-01 | 0.0596 |
79663 | HSPBAP1 | P1T-E | Human | Esophagus | ESCC | 1.83e-04 | 3.02e-01 | 0.0875 |
79663 | HSPBAP1 | P2T-E | Human | Esophagus | ESCC | 4.77e-09 | 1.29e-01 | 0.1177 |
79663 | HSPBAP1 | P4T-E | Human | Esophagus | ESCC | 7.70e-11 | 1.34e-01 | 0.1323 |
79663 | HSPBAP1 | P5T-E | Human | Esophagus | ESCC | 4.56e-04 | 9.78e-02 | 0.1327 |
79663 | HSPBAP1 | P8T-E | Human | Esophagus | ESCC | 2.31e-14 | 2.40e-01 | 0.0889 |
79663 | HSPBAP1 | P9T-E | Human | Esophagus | ESCC | 3.78e-14 | 2.12e-01 | 0.1131 |
79663 | HSPBAP1 | P10T-E | Human | Esophagus | ESCC | 4.67e-17 | 2.64e-01 | 0.116 |
79663 | HSPBAP1 | P11T-E | Human | Esophagus | ESCC | 2.66e-08 | 2.79e-01 | 0.1426 |
79663 | HSPBAP1 | P12T-E | Human | Esophagus | ESCC | 4.88e-10 | 2.60e-01 | 0.1122 |
79663 | HSPBAP1 | P15T-E | Human | Esophagus | ESCC | 3.28e-20 | 3.91e-01 | 0.1149 |
79663 | HSPBAP1 | P16T-E | Human | Esophagus | ESCC | 6.83e-11 | 2.10e-01 | 0.1153 |
79663 | HSPBAP1 | P20T-E | Human | Esophagus | ESCC | 2.44e-36 | 7.68e-01 | 0.1124 |
79663 | HSPBAP1 | P21T-E | Human | Esophagus | ESCC | 1.20e-16 | 2.84e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPBAP1 | SNV | Missense_Mutation | novel | c.1267N>C | p.Glu423Gln | p.E423Q | Q96EW2 | protein_coding | tolerated(0.46) | benign(0.005) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
HSPBAP1 | SNV | Missense_Mutation | c.989C>T | p.Ser330Phe | p.S330F | Q96EW2 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | ||
HSPBAP1 | SNV | Missense_Mutation | rs150374037 | c.1385N>T | p.Thr462Met | p.T462M | Q96EW2 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HSPBAP1 | SNV | Missense_Mutation | c.902C>T | p.Pro301Leu | p.P301L | Q96EW2 | protein_coding | tolerated(0.09) | benign(0.028) | TCGA-E2-A14X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
HSPBAP1 | SNV | Missense_Mutation | novel | c.955G>A | p.Ala319Thr | p.A319T | Q96EW2 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HSPBAP1 | SNV | Missense_Mutation | c.1018N>C | p.Glu340Gln | p.E340Q | Q96EW2 | protein_coding | tolerated(0.34) | benign(0) | TCGA-BI-A20A-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSPBAP1 | SNV | Missense_Mutation | c.467G>A | p.Arg156Lys | p.R156K | Q96EW2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
HSPBAP1 | SNV | Missense_Mutation | c.1138G>T | p.Asp380Tyr | p.D380Y | Q96EW2 | protein_coding | tolerated(0.17) | benign(0) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSPBAP1 | SNV | Missense_Mutation | c.1072G>A | p.Glu358Lys | p.E358K | Q96EW2 | protein_coding | tolerated(0.68) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSPBAP1 | SNV | Missense_Mutation | c.424N>A | p.Leu142Ile | p.L142I | Q96EW2 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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