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Gene: HSDL2 |
Gene summary for HSDL2 |
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Gene information | Species | Human | Gene symbol | HSDL2 | Gene ID | 84263 |
Gene name | hydroxysteroid dehydrogenase like 2 | |
Gene Alias | C9orf99 | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84263 | HSDL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.22e-04 | -3.43e-01 | 0.0155 |
84263 | HSDL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.56e-04 | -2.80e-01 | -0.1464 |
84263 | HSDL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.84e-02 | -2.89e-01 | 0.096 |
84263 | HSDL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.21e-03 | -2.33e-01 | 0.294 |
84263 | HSDL2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.11e-12 | -4.19e-01 | 0.3005 |
84263 | HSDL2 | F007 | Human | Colorectum | FAP | 3.08e-06 | -4.88e-01 | 0.1176 |
84263 | HSDL2 | A002-C-010 | Human | Colorectum | FAP | 1.65e-02 | -2.10e-01 | 0.242 |
84263 | HSDL2 | A001-C-207 | Human | Colorectum | FAP | 2.51e-03 | -2.79e-01 | 0.1278 |
84263 | HSDL2 | A015-C-203 | Human | Colorectum | FAP | 6.21e-28 | -4.48e-01 | -0.1294 |
84263 | HSDL2 | A015-C-204 | Human | Colorectum | FAP | 5.35e-08 | -4.27e-01 | -0.0228 |
84263 | HSDL2 | A014-C-040 | Human | Colorectum | FAP | 2.60e-03 | -4.15e-01 | -0.1184 |
84263 | HSDL2 | A002-C-201 | Human | Colorectum | FAP | 2.77e-14 | -3.75e-01 | 0.0324 |
84263 | HSDL2 | A002-C-203 | Human | Colorectum | FAP | 1.48e-04 | -2.56e-01 | 0.2786 |
84263 | HSDL2 | A001-C-119 | Human | Colorectum | FAP | 5.27e-08 | -4.17e-01 | -0.1557 |
84263 | HSDL2 | A001-C-108 | Human | Colorectum | FAP | 3.69e-19 | -4.41e-01 | -0.0272 |
84263 | HSDL2 | A002-C-205 | Human | Colorectum | FAP | 3.56e-21 | -4.99e-01 | -0.1236 |
84263 | HSDL2 | A001-C-104 | Human | Colorectum | FAP | 1.04e-07 | -3.83e-01 | 0.0184 |
84263 | HSDL2 | A015-C-005 | Human | Colorectum | FAP | 2.18e-06 | -3.96e-01 | -0.0336 |
84263 | HSDL2 | A015-C-006 | Human | Colorectum | FAP | 1.12e-14 | -5.24e-01 | -0.0994 |
84263 | HSDL2 | A015-C-106 | Human | Colorectum | FAP | 3.67e-13 | -3.27e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSDL2 | SNV | Missense_Mutation | novel | c.1094N>T | p.Ala365Val | p.A365V | Q6YN16 | protein_coding | tolerated(0.09) | benign(0.094) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HSDL2 | SNV | Missense_Mutation | c.247N>C | p.Ala83Pro | p.A83P | Q6YN16 | protein_coding | tolerated(0.25) | benign(0.121) | TCGA-B6-A0RO-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1250N>C | p.Arg417Thr | p.R417T | Q6YN16 | protein_coding | deleterious(0) | benign(0.103) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HSDL2 | SNV | Missense_Mutation | c.889N>C | p.Glu297Gln | p.E297Q | Q6YN16 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1142C>T | p.Ser381Leu | p.S381L | Q6YN16 | protein_coding | deleterious(0) | benign(0.338) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
HSDL2 | SNV | Missense_Mutation | novel | c.508N>T | p.Ile170Phe | p.I170F | Q6YN16 | protein_coding | deleterious(0) | benign(0.387) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HSDL2 | SNV | Missense_Mutation | c.1237N>G | p.Gln413Glu | p.Q413E | Q6YN16 | protein_coding | tolerated(0.22) | benign(0.108) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1159A>G | p.Thr387Ala | p.T387A | Q6YN16 | protein_coding | tolerated(0.23) | benign(0.254) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HSDL2 | SNV | Missense_Mutation | c.673N>A | p.Ala225Thr | p.A225T | Q6YN16 | protein_coding | deleterious(0.01) | possibly_damaging(0.822) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSDL2 | SNV | Missense_Mutation | c.660N>C | p.Lys220Asn | p.K220N | Q6YN16 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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