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Gene: HRASLS2 |
Gene summary for HRASLS2 |
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Gene information | Species | Human | Gene symbol | HRASLS2 | Gene ID | 54979 |
Gene name | phospholipase A and acyltransferase 2 | |
Gene Alias | HRASLS2 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9NWW9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54979 | HRASLS2 | Pat01-B | Human | Stomach | GC | 2.60e-12 | -5.26e-01 | 0.5754 |
54979 | HRASLS2 | Pat02-B | Human | Stomach | GC | 1.55e-13 | -5.26e-01 | 0.0368 |
54979 | HRASLS2 | Pat03-B | Human | Stomach | GC | 3.92e-10 | -5.26e-01 | 0.3693 |
54979 | HRASLS2 | Pat04-B | Human | Stomach | GC | 4.41e-04 | -5.26e-01 | -0.1483 |
54979 | HRASLS2 | Pat05-B | Human | Stomach | GC | 1.42e-03 | -5.26e-01 | -0.0353 |
54979 | HRASLS2 | Pat06-B | Human | Stomach | GC | 4.31e-10 | -5.26e-01 | -0.1961 |
54979 | HRASLS2 | Pat08-B | Human | Stomach | GC | 1.07e-02 | -5.26e-01 | 0.0182 |
54979 | HRASLS2 | Pat09-B | Human | Stomach | GC | 2.64e-08 | -5.26e-01 | -0.0359 |
54979 | HRASLS2 | Pat11-B | Human | Stomach | GC | 5.40e-03 | -5.26e-01 | -0.182 |
54979 | HRASLS2 | Pat12-B | Human | Stomach | GC | 4.51e-11 | -5.26e-01 | 0.0325 |
54979 | HRASLS2 | Pat13-B | Human | Stomach | GC | 5.90e-05 | -5.26e-01 | 0.0555 |
54979 | HRASLS2 | Pat15-B | Human | Stomach | GC | 3.26e-08 | -5.26e-01 | -0.0778 |
54979 | HRASLS2 | Pat16-B | Human | Stomach | GC | 1.55e-13 | -5.26e-01 | 0.1918 |
54979 | HRASLS2 | Pat17-B | Human | Stomach | GC | 8.23e-12 | -5.26e-01 | 0.3109 |
54979 | HRASLS2 | Pat18-B | Human | Stomach | GC | 1.69e-09 | -5.26e-01 | -0.0432 |
54979 | HRASLS2 | Pat19-B | Human | Stomach | GC | 1.34e-06 | -5.26e-01 | 0.0826 |
54979 | HRASLS2 | Pat22-B | Human | Stomach | GC | 1.28e-08 | -5.26e-01 | -0.1042 |
54979 | HRASLS2 | Pat24-B | Human | Stomach | GC | 7.56e-05 | -5.26e-01 | -0.1184 |
54979 | HRASLS2 | Pat25-A | Human | Stomach | CAG with IM | 8.23e-12 | -5.26e-01 | -0.1648 |
54979 | HRASLS2 | Pat26-A | Human | Stomach | CSG | 1.69e-12 | -5.26e-01 | -0.2402 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HRASLS2 | SNV | Missense_Mutation | novel | c.187N>A | p.Glu63Lys | p.E63K | Q9NWW9 | protein_coding | deleterious(0) | possibly_damaging(0.833) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HRASLS2 | SNV | Missense_Mutation | novel | c.362N>A | p.Arg121His | p.R121H | Q9NWW9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HRASLS2 | SNV | Missense_Mutation | c.50C>A | p.Ser17Tyr | p.S17Y | Q9NWW9 | protein_coding | tolerated(0.1) | benign(0.216) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS2 | SNV | Missense_Mutation | c.424N>T | p.Gly142Cys | p.G142C | Q9NWW9 | protein_coding | tolerated(0.18) | possibly_damaging(0.635) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HRASLS2 | SNV | Missense_Mutation | c.151N>A | p.Leu51Met | p.L51M | Q9NWW9 | protein_coding | tolerated(1) | benign(0.017) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS2 | SNV | Missense_Mutation | novel | c.485N>G | p.Gln162Arg | p.Q162R | Q9NWW9 | protein_coding | tolerated(0.1) | probably_damaging(0.954) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
HRASLS2 | SNV | Missense_Mutation | novel | c.220N>C | p.Tyr74His | p.Y74H | Q9NWW9 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HRASLS2 | SNV | Missense_Mutation | rs151240711 | c.53N>A | p.Arg18His | p.R18H | Q9NWW9 | protein_coding | deleterious(0.04) | probably_damaging(0.909) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HRASLS2 | SNV | Missense_Mutation | c.440N>T | p.Ala147Val | p.A147V | Q9NWW9 | protein_coding | tolerated(0.76) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS2 | SNV | Missense_Mutation | rs142689067 | c.370N>A | p.Val124Ile | p.V124I | Q9NWW9 | protein_coding | tolerated(0.18) | benign(0.052) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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