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Gene: HRASLS |
Gene summary for HRASLS |
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Gene information | Species | Human | Gene symbol | HRASLS | Gene ID | 57110 |
Gene name | phospholipase A and acyltransferase 1 | |
Gene Alias | A-C1 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q86WS9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57110 | HRASLS | P2T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.29e-01 | 0.1177 |
57110 | HRASLS | P4T-E | Human | Esophagus | ESCC | 3.78e-04 | 1.54e-01 | 0.1323 |
57110 | HRASLS | P10T-E | Human | Esophagus | ESCC | 1.59e-30 | 5.21e-01 | 0.116 |
57110 | HRASLS | P15T-E | Human | Esophagus | ESCC | 3.38e-04 | 1.26e-01 | 0.1149 |
57110 | HRASLS | P16T-E | Human | Esophagus | ESCC | 3.97e-04 | 9.77e-02 | 0.1153 |
57110 | HRASLS | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 1.44e-01 | 0.1124 |
57110 | HRASLS | P22T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.30e-01 | 0.1236 |
57110 | HRASLS | P23T-E | Human | Esophagus | ESCC | 5.52e-07 | 1.90e-01 | 0.108 |
57110 | HRASLS | P26T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.04e-01 | 0.1276 |
57110 | HRASLS | P27T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.72e-01 | 0.1055 |
57110 | HRASLS | P31T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.91e-01 | 0.1251 |
57110 | HRASLS | P32T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.66e-01 | 0.1666 |
57110 | HRASLS | P36T-E | Human | Esophagus | ESCC | 1.12e-05 | 2.34e-01 | 0.1187 |
57110 | HRASLS | P37T-E | Human | Esophagus | ESCC | 6.65e-04 | 1.16e-01 | 0.1371 |
57110 | HRASLS | P61T-E | Human | Esophagus | ESCC | 1.48e-02 | 1.01e-01 | 0.099 |
57110 | HRASLS | P62T-E | Human | Esophagus | ESCC | 2.29e-08 | 2.06e-01 | 0.1302 |
57110 | HRASLS | P74T-E | Human | Esophagus | ESCC | 6.03e-32 | 7.66e-01 | 0.1479 |
57110 | HRASLS | P76T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.84e-01 | 0.1207 |
57110 | HRASLS | P79T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.86e-02 | 0.1154 |
57110 | HRASLS | P83T-E | Human | Esophagus | ESCC | 1.84e-08 | 2.31e-01 | 0.1738 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HRASLS | SNV | Missense_Mutation | rs147242865 | c.742N>A | p.Val248Ile | p.V248I | protein_coding | tolerated(0.86) | benign(0.014) | TCGA-B6-A0RM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.715N>C | p.Glu239Gln | p.E239Q | protein_coding | tolerated(0.17) | benign(0.041) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.808G>A | p.Ala270Thr | p.A270T | protein_coding | tolerated_low_confidence(0.44) | benign(0) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.725A>G | p.Asn242Ser | p.N242S | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
HRASLS | SNV | Missense_Mutation | rs755206372 | c.694N>T | p.Arg232Cys | p.R232C | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.386N>C | p.Phe129Ser | p.F129S | protein_coding | tolerated(0.06) | probably_damaging(0.962) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
HRASLS | SNV | Missense_Mutation | c.346N>C | p.Tyr116His | p.Y116H | protein_coding | tolerated(0.06) | benign(0.2) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
HRASLS | SNV | Missense_Mutation | rs765992357 | c.545N>G | p.Asn182Ser | p.N182S | protein_coding | tolerated(0.15) | benign(0.053) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.632N>C | p.Ile211Thr | p.I211T | protein_coding | deleterious(0.01) | benign(0.053) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HRASLS | SNV | Missense_Mutation | novel | c.774N>A | p.Phe258Leu | p.F258L | protein_coding | tolerated(0.25) | benign(0.283) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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