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Gene: HOXC13 |
Gene summary for HOXC13 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HOXC13 | Gene ID | 3229 |
| Gene name | homeobox C13 | |
| Gene Alias | ECTD9 | |
| Cytomap | 12q13.13 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P31276 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3229 | HOXC13 | C04 | Human | Oral cavity | OSCC | 6.21e-03 | 2.20e-01 | 0.2633 |
| 3229 | HOXC13 | C21 | Human | Oral cavity | OSCC | 2.49e-03 | 1.57e-01 | 0.2678 |
| 3229 | HOXC13 | C30 | Human | Oral cavity | OSCC | 3.74e-18 | 5.85e-01 | 0.3055 |
| 3229 | HOXC13 | C51 | Human | Oral cavity | OSCC | 4.98e-04 | 2.05e-01 | 0.2674 |
| 3229 | HOXC13 | C06 | Human | Oral cavity | OSCC | 1.28e-06 | 5.41e-01 | 0.2699 |
| 3229 | HOXC13 | SYSMH2 | Human | Oral cavity | OSCC | 1.66e-02 | 1.12e-01 | 0.2326 |
| 3229 | HOXC13 | SYSMH3 | Human | Oral cavity | OSCC | 3.71e-12 | 2.57e-01 | 0.2442 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| HOXC13 | MDSCs | Esophagus | ADJ | ATG101,MIEN1,ZFP37, etc. | 7.32e-02 |  |
| HOXC13 | MDSCs | Esophagus | ESCC | ATG101,MIEN1,ZFP37, etc. | 2.25e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HOXC13 | SNV | Missense_Mutation | novel | c.725C>A | p.Ser242Tyr | p.S242Y | P31276 | protein_coding | deleterious(0.03) | benign(0.265) | TCGA-A7-A4SA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
| HOXC13 | SNV | Missense_Mutation | rs772386896 | c.739N>A | p.Val247Met | p.V247M | P31276 | protein_coding | deleterious(0.03) | benign(0.372) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| HOXC13 | SNV | Missense_Mutation | c.461N>T | p.Pro154Leu | p.P154L | P31276 | protein_coding | tolerated(0.34) | benign(0.019) | TCGA-EA-A5FO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| HOXC13 | SNV | Missense_Mutation | novel | c.826N>A | p.Glu276Lys | p.E276K | P31276 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
| HOXC13 | SNV | Missense_Mutation | c.844N>C | p.Ser282Arg | p.S282R | P31276 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| HOXC13 | SNV | Missense_Mutation | c.910N>T | p.Val304Leu | p.V304L | P31276 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| HOXC13 | SNV | Missense_Mutation | c.868N>T | p.Arg290Cys | p.R290C | P31276 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| HOXC13 | SNV | Missense_Mutation | novel | c.830N>C | p.Lys277Thr | p.K277T | P31276 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| HOXC13 | SNV | Missense_Mutation | c.790N>T | p.Arg264Cys | p.R264C | P31276 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| HOXC13 | SNV | Missense_Mutation | novel | c.864N>T | p.Glu288Asp | p.E288D | P31276 | protein_coding | tolerated(1) | benign(0.02) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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