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Gene: HOXB8 |
Gene summary for HOXB8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HOXB8 | Gene ID | 3218 |
| Gene name | homeobox B8 | |
| Gene Alias | HOX2 | |
| Cytomap | 17q21.32 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P17481 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3218 | HOXB8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.30e-05 | 1.39e-01 | 0.0155 |
| 3218 | HOXB8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.73e-09 | 3.19e-01 | -0.0811 |
| 3218 | HOXB8 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.35e-06 | 1.91e-01 | -0.1088 |
| 3218 | HOXB8 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.79e-04 | 2.18e-01 | -0.1526 |
| 3218 | HOXB8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.00e-13 | 3.32e-01 | -0.059 |
| 3218 | HOXB8 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.00e-02 | 1.18e-01 | 0.096 |
| 3218 | HOXB8 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.20e-14 | 8.37e-01 | 0.0446 |
| 3218 | HOXB8 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.52e-14 | 8.45e-01 | 0.0528 |
| 3218 | HOXB8 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 5.21e-01 | 0.0131 |
| 3218 | HOXB8 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.64e-05 | 4.15e-01 | 0.0171 |
| 3218 | HOXB8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.85e-03 | 1.22e-01 | 0.0674 |
| 3218 | HOXB8 | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.81e-02 | 3.33e-01 | -0.0124 |
| 3218 | HOXB8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.03e-17 | 5.47e-01 | 0.0588 |
| 3218 | HOXB8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.13e-53 | 1.08e+00 | 0.294 |
| 3218 | HOXB8 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.28e-10 | 8.88e-01 | 0.3487 |
| 3218 | HOXB8 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.54e-35 | 1.41e+00 | 0.281 |
| 3218 | HOXB8 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.38e-32 | 6.91e-01 | 0.3859 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
| GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
| GO:0045637 | Colorectum | AD | regulation of myeloid cell differentiation | 61/3918 | 210/18723 | 3.17e-03 | 2.35e-02 | 61 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
| GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
| GO:19037061 | Colorectum | MSS | regulation of hemopoiesis | 89/3467 | 367/18723 | 3.39e-03 | 2.56e-02 | 89 |
| GO:00456371 | Colorectum | MSS | regulation of myeloid cell differentiation | 54/3467 | 210/18723 | 5.85e-03 | 3.96e-02 | 54 |
| GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
| GO:00300993 | Colorectum | MSI-H | myeloid cell differentiation | 50/1319 | 381/18723 | 1.52e-05 | 6.62e-04 | 50 |
| GO:0008344 | Colorectum | MSI-H | adult locomotory behavior | 13/1319 | 71/18723 | 1.24e-03 | 2.00e-02 | 13 |
| GO:19037062 | Colorectum | MSI-H | regulation of hemopoiesis | 41/1319 | 367/18723 | 2.31e-03 | 3.09e-02 | 41 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HOXB8 | SNV | Missense_Mutation | c.663N>T | p.Glu221Asp | p.E221D | P17481 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| HOXB8 | SNV | Missense_Mutation | novel | c.255C>A | p.Phe85Leu | p.F85L | P17481 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| HOXB8 | SNV | Missense_Mutation | c.94C>A | p.Leu32Met | p.L32M | P17481 | protein_coding | tolerated(0.3) | probably_damaging(0.986) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
| HOXB8 | SNV | Missense_Mutation | novel | c.82T>C | p.Phe28Leu | p.F28L | P17481 | protein_coding | tolerated(0.11) | probably_damaging(0.914) | TCGA-D1-A1NZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HOXB8 | SNV | Missense_Mutation | novel | c.463N>T | p.Arg155Cys | p.R155C | P17481 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
| HOXB8 | SNV | Missense_Mutation | novel | c.255N>A | p.Phe85Leu | p.F85L | P17481 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
| HOXB8 | SNV | Missense_Mutation | novel | c.218N>A | p.Pro73Gln | p.P73Q | P17481 | protein_coding | tolerated(0.08) | possibly_damaging(0.9) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| HOXB8 | SNV | Missense_Mutation | novel | c.400N>T | p.Leu134Phe | p.L134F | P17481 | protein_coding | deleterious(0.01) | possibly_damaging(0.852) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| HOXB8 | SNV | Missense_Mutation | novel | c.256N>A | p.Tyr86Asn | p.Y86N | P17481 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| HOXB8 | SNV | Missense_Mutation | c.657N>T | p.Glu219Asp | p.E219D | P17481 | protein_coding | tolerated(0.49) | benign(0.01) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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