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Gene: HOXB6 |
Gene summary for HOXB6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HOXB6 | Gene ID | 3216 |
| Gene name | homeobox B6 | |
| Gene Alias | HOX2 | |
| Cytomap | 17q21.32 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P17509 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3216 | HOXB6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.74e-05 | 2.40e-01 | -0.1808 |
| 3216 | HOXB6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.87e-19 | 5.89e-01 | -0.0811 |
| 3216 | HOXB6 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.21e-21 | 5.89e-01 | -0.1088 |
| 3216 | HOXB6 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.44e-06 | 1.64e-01 | -0.1954 |
| 3216 | HOXB6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.63e-04 | 2.60e-01 | -0.1207 |
| 3216 | HOXB6 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.04e-05 | 2.40e-01 | -0.1526 |
| 3216 | HOXB6 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.63e-08 | 2.14e-01 | -0.1464 |
| 3216 | HOXB6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.10e-16 | 4.18e-01 | -0.059 |
| 3216 | HOXB6 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.35e-05 | 4.87e-01 | -0.00410000000000005 |
| 3216 | HOXB6 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.63e-10 | 3.17e-01 | 0.096 |
| 3216 | HOXB6 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.44e-06 | 3.97e-01 | 0.0446 |
| 3216 | HOXB6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.64e-16 | 6.39e-01 | 0.0528 |
| 3216 | HOXB6 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.81e-17 | 9.01e-01 | 0.0131 |
| 3216 | HOXB6 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.70e-09 | 6.27e-01 | 0.0171 |
| 3216 | HOXB6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.87e-14 | 4.19e-01 | 0.0338 |
| 3216 | HOXB6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.80e-12 | 3.43e-01 | 0.0674 |
| 3216 | HOXB6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.78e-03 | 3.08e-01 | 0.0112 |
| 3216 | HOXB6 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.31e-20 | 6.21e-01 | 0.0588 |
| 3216 | HOXB6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.04e-57 | 1.18e+00 | 0.294 |
| 3216 | HOXB6 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.07e-05 | 7.05e-01 | 0.3487 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0034101 | Colorectum | AD | erythrocyte homeostasis | 51/3918 | 129/18723 | 1.07e-06 | 3.59e-05 | 51 |
| GO:0002262 | Colorectum | AD | myeloid cell homeostasis | 57/3918 | 157/18723 | 6.17e-06 | 1.56e-04 | 57 |
| GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:00341011 | Colorectum | SER | erythrocyte homeostasis | 39/2897 | 129/18723 | 1.70e-05 | 5.11e-04 | 39 |
| GO:00022621 | Colorectum | SER | myeloid cell homeostasis | 44/2897 | 157/18723 | 4.09e-05 | 1.03e-03 | 44 |
| GO:00488721 | Colorectum | SER | homeostasis of number of cells | 65/2897 | 272/18723 | 1.70e-04 | 3.19e-03 | 65 |
| GO:00341012 | Colorectum | MSS | erythrocyte homeostasis | 49/3467 | 129/18723 | 1.58e-07 | 7.19e-06 | 49 |
| GO:00022622 | Colorectum | MSS | myeloid cell homeostasis | 55/3467 | 157/18723 | 6.35e-07 | 2.34e-05 | 55 |
| GO:00488722 | Colorectum | MSS | homeostasis of number of cells | 82/3467 | 272/18723 | 2.02e-06 | 6.28e-05 | 82 |
| GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
| GO:00341013 | Colorectum | MSI-H | erythrocyte homeostasis | 24/1319 | 129/18723 | 1.03e-05 | 4.79e-04 | 24 |
| GO:00022623 | Colorectum | MSI-H | myeloid cell homeostasis | 26/1319 | 157/18723 | 3.79e-05 | 1.43e-03 | 26 |
| GO:00488723 | Colorectum | MSI-H | homeostasis of number of cells | 34/1319 | 272/18723 | 8.10e-04 | 1.49e-02 | 34 |
| GO:0048872210 | Thyroid | ATC | homeostasis of number of cells | 135/6293 | 272/18723 | 2.92e-08 | 5.50e-07 | 135 |
| GO:000226234 | Thyroid | ATC | myeloid cell homeostasis | 84/6293 | 157/18723 | 2.12e-07 | 3.33e-06 | 84 |
| GO:003410134 | Thyroid | ATC | erythrocyte homeostasis | 71/6293 | 129/18723 | 4.36e-07 | 6.34e-06 | 71 |
| GO:00487053 | Thyroid | ATC | skeletal system morphogenesis | 101/6293 | 220/18723 | 9.48e-05 | 6.93e-04 | 101 |
| GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| HOXB6 | CILIA | Endometrium | ADJ | HOXB2,HOXB7,HOXB5, etc. | 1.56e-01 |  |
| HOXB6 | STM | Endometrium | EEC | HOXB2,HOXB7,HOXB5, etc. | 4.45e-01 |  |
| HOXB6 | STM | Endometrium | Healthy | SPINT2,HOXB2,ASRGL1, etc. | 1.81e-01 |  |
| HOXB6 | DUCT2 | Pancreas | ADJ | HOXB2,SERPINB3,CEACAM6, etc. | 2.32e-02 |  |
| HOXB6 | ISLET | Pancreas | PanIN | HOXB2,SERPINB3,CEACAM6, etc. | 1.23e-03 |  |
| HOXB6 | PANIN | Pancreas | PanIN | HOXB2,SERPINB3,CEACAM6, etc. | 3.93e-02 | |
| HOXB6 | DUCT2 | Pancreas | PanIN | HOXB2,SERPINB3,CEACAM6, etc. | 0.00e+00 | |
| HOXB6 | TFC | Thyroid | goiters | KCNMA1,ATF4,ROBO3, etc. | 1.31e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HOXB6 | SNV | Missense_Mutation | c.443N>A | p.Arg148Gln | p.R148Q | P17509 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HOXB6 | SNV | Missense_Mutation | c.422C>T | p.Ser141Phe | p.S141F | P17509 | protein_coding | tolerated(0.07) | benign(0.093) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| HOXB6 | SNV | Missense_Mutation | c.539N>T | p.Ala180Val | p.A180V | P17509 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
| HOXB6 | deletion | Frame_Shift_Del | c.663delA | p.Lys221AsnfsTer66 | p.K221Nfs*66 | P17509 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
| HOXB6 | SNV | Missense_Mutation | novel | c.577N>C | p.Trp193Arg | p.W193R | P17509 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| HOXB6 | SNV | Missense_Mutation | c.527N>A | p.Arg176His | p.R176H | P17509 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| HOXB6 | SNV | Missense_Mutation | rs768603811 | c.292N>T | p.Pro98Ser | p.P98S | P17509 | protein_coding | tolerated(0.75) | benign(0.022) | TCGA-AX-A2H7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| HOXB6 | SNV | Missense_Mutation | novel | c.383A>G | p.Tyr128Cys | p.Y128C | P17509 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HOXB6 | SNV | Missense_Mutation | c.7N>A | p.Ser3Thr | p.S3T | P17509 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
| HOXB6 | SNV | Missense_Mutation | c.373N>T | p.Thr125Ser | p.T125S | P17509 | protein_coding | tolerated(0.62) | benign(0.083) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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