|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: HOXB5 |
Gene summary for HOXB5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HOXB5 | Gene ID | 3215 |
| Gene name | homeobox B5 | |
| Gene Alias | HHO.C10 | |
| Cytomap | 17q21.32 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P09067 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3215 | HOXB5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.90e-11 | 2.32e-01 | 0.0155 |
| 3215 | HOXB5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 2.66e-01 | -0.1808 |
| 3215 | HOXB5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
| 3215 | HOXB5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-19 | 5.81e-01 | -0.0811 |
| 3215 | HOXB5 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.41e-14 | 3.25e-01 | -0.1088 |
| 3215 | HOXB5 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-17 | 3.28e-01 | -0.1954 |
| 3215 | HOXB5 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.68e-01 | -0.2602 |
| 3215 | HOXB5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-04 | 1.91e-01 | -0.1207 |
| 3215 | HOXB5 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.95e-13 | 3.71e-01 | -0.1526 |
| 3215 | HOXB5 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.19e-01 | -0.1464 |
| 3215 | HOXB5 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.11e-14 | 2.97e-01 | -0.1001 |
| 3215 | HOXB5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.12e-24 | 5.34e-01 | -0.059 |
| 3215 | HOXB5 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.66e-12 | 4.42e-01 | -0.0842 |
| 3215 | HOXB5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.36e-07 | 1.83e-01 | 0.096 |
| 3215 | HOXB5 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.89e-01 | 0.0446 |
| 3215 | HOXB5 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.03e-05 | 3.72e-01 | 0.0451 |
| 3215 | HOXB5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.47e-01 | 0.0528 |
| 3215 | HOXB5 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-08 | 4.31e-01 | 0.0131 |
| 3215 | HOXB5 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.21e-08 | 3.35e-01 | -0.0177 |
| 3215 | HOXB5 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.64e-10 | 5.97e-01 | 0.0171 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0003158 | Colorectum | AD | endothelium development | 44/3918 | 136/18723 | 1.20e-03 | 1.07e-02 | 44 |
| GO:0045446 | Colorectum | AD | endothelial cell differentiation | 39/3918 | 118/18723 | 1.42e-03 | 1.22e-02 | 39 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:00031581 | Colorectum | MSS | endothelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
| GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
| GO:00454461 | Colorectum | MSS | endothelial cell differentiation | 33/3467 | 118/18723 | 7.66e-03 | 4.81e-02 | 33 |
| GO:00031582 | Colorectum | MSI-H | endothelium development | 19/1319 | 136/18723 | 3.19e-03 | 3.93e-02 | 19 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| HOXB5 | CD8TEXINT | Esophagus | ADJ | FAN1,SLAMF8,RSPH3, etc. | 2.65e-01 |  |
| HOXB5 | CD8TEXP | Esophagus | ADJ | FAN1,SLAMF8,RSPH3, etc. | 6.96e-02 | |
| HOXB5 | CD8TEXP | Esophagus | ESCC | FAN1,SLAMF8,RSPH3, etc. | 1.11e-01 |  |
| HOXB5 | ECM | Thyroid | HT | TAL1,TMSB4XP4,SMAD6, etc. | 3.76e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HOXB5 | SNV | Missense_Mutation | c.714N>G | p.Ile238Met | p.I238M | P09067 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HOXB5 | SNV | Missense_Mutation | c.403N>A | p.Glu135Lys | p.E135K | P09067 | protein_coding | tolerated(0.82) | benign(0.053) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HOXB5 | SNV | Missense_Mutation | novel | c.633G>T | p.Lys211Asn | p.K211N | P09067 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MS-A51U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| HOXB5 | insertion | In_Frame_Ins | novel | c.327_328insAAA | p.Gly109_Ala110insLys | p.G109_A110insK | P09067 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
| HOXB5 | SNV | Missense_Mutation | novel | c.14N>C | p.Phe5Ser | p.F5S | P09067 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| HOXB5 | SNV | Missense_Mutation | novel | c.754N>A | p.Asp252Asn | p.D252N | P09067 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-4007-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| HOXB5 | SNV | Missense_Mutation | novel | c.35N>A | p.Arg12His | p.R12H | P09067 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HOXB5 | SNV | Missense_Mutation | c.665G>A | p.Arg222Gln | p.R222Q | P09067 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| HOXB5 | SNV | Missense_Mutation | novel | c.466N>T | p.Arg156Trp | p.R156W | P09067 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| HOXB5 | SNV | Missense_Mutation | novel | c.584N>G | p.Lys195Arg | p.K195R | P09067 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |