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Gene: HOXB2 |
Gene summary for HOXB2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HOXB2 | Gene ID | 3212 |
| Gene name | homeobox B2 | |
| Gene Alias | HOX2 | |
| Cytomap | 17q21.32 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P14652 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3212 | HOXB2 | GSM4909286 | Human | Breast | IDC | 1.57e-03 | -1.21e-01 | 0.1081 |
| 3212 | HOXB2 | GSM4909287 | Human | Breast | IDC | 2.44e-02 | -1.22e-01 | 0.2057 |
| 3212 | HOXB2 | GSM4909293 | Human | Breast | IDC | 7.48e-03 | -1.12e-01 | 0.1581 |
| 3212 | HOXB2 | GSM4909297 | Human | Breast | IDC | 7.43e-04 | -1.18e-01 | 0.1517 |
| 3212 | HOXB2 | GSM4909298 | Human | Breast | IDC | 1.32e-02 | -1.11e-01 | 0.1551 |
| 3212 | HOXB2 | GSM4909306 | Human | Breast | IDC | 2.37e-02 | 2.09e-01 | 0.1564 |
| 3212 | HOXB2 | GSM4909307 | Human | Breast | IDC | 7.86e-09 | 3.81e-01 | 0.1569 |
| 3212 | HOXB2 | GSM4909308 | Human | Breast | IDC | 2.15e-48 | 8.24e-01 | 0.158 |
| 3212 | HOXB2 | GSM4909311 | Human | Breast | IDC | 2.02e-04 | -1.76e-02 | 0.1534 |
| 3212 | HOXB2 | GSM4909319 | Human | Breast | IDC | 2.41e-07 | -6.62e-03 | 0.1563 |
| 3212 | HOXB2 | M2 | Human | Breast | IDC | 9.49e-03 | 3.38e-01 | 0.21 |
| 3212 | HOXB2 | M5 | Human | Breast | IDC | 5.57e-08 | 6.85e-01 | 0.1598 |
| 3212 | HOXB2 | NCCBC14 | Human | Breast | DCIS | 2.08e-06 | 3.88e-01 | 0.2021 |
| 3212 | HOXB2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.84e-07 | 5.98e-01 | 0.0131 |
| 3212 | HOXB2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.23e-03 | 4.88e-01 | 0.0171 |
| 3212 | HOXB2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.49e-13 | 4.71e-01 | 0.0588 |
| 3212 | HOXB2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.01e-03 | 6.70e-01 | 0.3487 |
| 3212 | HOXB2 | LZE4T | Human | Esophagus | ESCC | 8.16e-04 | -3.05e-02 | 0.0811 |
| 3212 | HOXB2 | LZE24T | Human | Esophagus | ESCC | 4.24e-39 | 1.25e+00 | 0.0596 |
| 3212 | HOXB2 | P1T-E | Human | Esophagus | ESCC | 7.93e-04 | 3.70e-01 | 0.0875 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004885713 | Breast | IDC | neural nucleus development | 21/1434 | 64/18723 | 5.35e-09 | 4.28e-07 | 21 |
| GO:004885723 | Breast | DCIS | neural nucleus development | 20/1390 | 64/18723 | 1.87e-08 | 1.29e-06 | 20 |
| GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
| GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
| GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
| GO:00488573 | Colorectum | MSI-H | neural nucleus development | 13/1319 | 64/18723 | 4.43e-04 | 9.50e-03 | 13 |
| GO:00020115 | Esophagus | ESCC | morphogenesis of an epithelial sheet | 42/8552 | 57/18723 | 1.62e-05 | 1.45e-04 | 42 |
| GO:004885718 | Esophagus | ESCC | neural nucleus development | 44/8552 | 64/18723 | 1.59e-04 | 1.05e-03 | 44 |
| GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
| GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
| GO:00020114 | Oral cavity | OSCC | morphogenesis of an epithelial sheet | 37/7305 | 57/18723 | 6.66e-05 | 5.38e-04 | 37 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| HOXB2 | MLUM | Breast | Healthy | HOXB-AS1,RASSF6,C12orf73, etc. | 4.00e-01 |  |
| HOXB2 | ABS | Colorectum | MSI-H | TMEM132C,SOD3,SORCS2, etc. | 2.70e-01 |  |
| HOXB2 | IMENT | Colorectum | MSI-H | TMEM132C,SOD3,SORCS2, etc. | 9.51e-02 | |
| HOXB2 | ASC | Colorectum | MSI-H | TMEM132C,SOD3,SORCS2, etc. | 1.31e-01 | |
| HOXB2 | SSC | Colorectum | SER | TMEM132C,SOD3,SORCS2, etc. | 1.95e-02 |  |
| HOXB2 | ICAF | Colorectum | ADJ | YJU2,MRTO4,MIR4435-2HG, etc. | 2.07e-01 |  |
| HOXB2 | SMC | Endometrium | ADJ | SLPI,MT-ND2,CSRP2, etc. | 4.12e-01 |  |
| HOXB2 | SMC | Endometrium | AEH | SLPI,MT-ND2,CSRP2, etc. | 3.13e-01 |  |
| HOXB2 | SMC | Endometrium | EEC | SLPI,MT-ND2,CSRP2, etc. | 2.09e-01 |  |
| HOXB2 | SMC | Endometrium | Healthy | SLPI,MT-ND2,CSRP2, etc. | 3.94e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 3 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HOXB2 | SNV | Missense_Mutation | novel | c.991N>A | p.Asp331Asn | p.D331N | P14652 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| HOXB2 | SNV | Missense_Mutation | c.340N>T | p.Pro114Ser | p.P114S | P14652 | protein_coding | tolerated(0.51) | benign(0.007) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HOXB2 | SNV | Missense_Mutation | c.107N>T | p.Ser36Leu | p.S36L | P14652 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HOXB2 | SNV | Missense_Mutation | c.215C>T | p.Ala72Val | p.A72V | P14652 | protein_coding | tolerated(0.07) | benign(0.115) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| HOXB2 | SNV | Missense_Mutation | c.597N>T | p.Lys199Asn | p.K199N | P14652 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| HOXB2 | SNV | Missense_Mutation | novel | c.614N>T | p.Arg205Leu | p.R205L | P14652 | protein_coding | deleterious(0.01) | benign(0.122) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| HOXB2 | insertion | Nonsense_Mutation | novel | c.974_975insGTACTTTGGATATCCTAGGGGTGAGAGGTCTTAGT | p.Ser325ArgfsTer12 | p.S325Rfs*12 | P14652 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| HOXB2 | insertion | Frame_Shift_Ins | novel | c.27_28insT | p.Gly10TrpfsTer156 | p.G10Wfs*156 | P14652 | protein_coding | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD | ||
| HOXB2 | insertion | Nonsense_Mutation | novel | c.797_798insAATGCAGACCCACCAGTCTTGACCAACAACTTCATTTTACGTATCAA | p.Leu267MetfsTer7 | p.L267Mfs*7 | P14652 | protein_coding | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
| HOXB2 | SNV | Missense_Mutation | c.50C>T | p.Ser17Leu | p.S17L | P14652 | protein_coding | deleterious(0) | possibly_damaging(0.662) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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