Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HOXA10

Gene summary for HOXA10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HOXA10

Gene ID

3206

Gene namehomeobox A10
Gene AliasHOX1
Cytomap7p15.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P31260


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3206HOXA10HTA11_3410_2000001011HumanColorectumAD6.00e-081.79e-010.0155
3206HOXA10HTA11_2487_2000001011HumanColorectumSER2.89e-041.62e-01-0.1808
3206HOXA10HTA11_1938_2000001011HumanColorectumAD2.86e-063.09e-01-0.0811
3206HOXA10HTA11_78_2000001011HumanColorectumAD2.65e-102.84e-01-0.1088
3206HOXA10HTA11_347_2000001011HumanColorectumAD6.17e-173.40e-01-0.1954
3206HOXA10HTA11_3361_2000001011HumanColorectumAD5.46e-031.46e-01-0.1207
3206HOXA10HTA11_83_2000001011HumanColorectumSER1.79e-041.77e-01-0.1526
3206HOXA10HTA11_696_2000001011HumanColorectumAD4.28e-102.47e-01-0.1464
3206HOXA10HTA11_866_2000001011HumanColorectumAD9.55e-092.01e-01-0.1001
3206HOXA10HTA11_1391_2000001011HumanColorectumAD7.96e-092.74e-01-0.059
3206HOXA10HTA11_5212_2000001011HumanColorectumAD3.97e-042.15e-01-0.2061
3206HOXA10HTA11_7862_2000001011HumanColorectumAD4.79e-052.52e-01-0.0179
3206HOXA10HTA11_866_3004761011HumanColorectumAD1.85e-214.54e-010.096
3206HOXA10HTA11_4255_2000001011HumanColorectumSER3.40e-022.22e-010.0446
3206HOXA10HTA11_7663_2000001011HumanColorectumSER6.81e-042.31e-010.0131
3206HOXA10HTA11_10623_2000001011HumanColorectumAD4.46e-063.17e-01-0.0177
3206HOXA10HTA11_10711_2000001011HumanColorectumAD4.64e-041.44e-010.0338
3206HOXA10HTA11_7696_3000711011HumanColorectumAD8.94e-112.41e-010.0674
3206HOXA10HTA11_6818_2000001011HumanColorectumAD7.64e-125.04e-010.0112
3206HOXA10HTA11_6818_2000001021HumanColorectumAD3.33e-114.49e-010.0588
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0061458ColorectumADreproductive system development116/3918427/187231.11e-031.01e-02116
GO:0048608ColorectumADreproductive structure development114/3918424/187231.78e-031.47e-02114
GO:0048736ColorectumADappendage development51/3918172/187234.20e-032.89e-0251
GO:0060173ColorectumADlimb development51/3918172/187234.20e-032.89e-0251
GO:00487361ColorectumSERappendage development42/2897172/187231.43e-031.55e-0242
GO:00601731ColorectumSERlimb development42/2897172/187231.43e-031.55e-0242
GO:00614581ColorectumSERreproductive system development87/2897427/187233.69e-033.07e-0287
GO:0035107ColorectumSERappendage morphogenesis33/2897138/187236.10e-034.42e-0233
GO:0035108ColorectumSERlimb morphogenesis33/2897138/187236.10e-034.42e-0233
GO:00486081ColorectumSERreproductive structure development85/2897424/187236.33e-034.56e-0285
GO:00614582ColorectumMSSreproductive system development115/3467427/187239.86e-062.39e-04115
GO:00486082ColorectumMSSreproductive structure development113/3467424/187231.94e-054.18e-04113
GO:00487362ColorectumMSSappendage development48/3467172/187231.61e-031.46e-0248
GO:00601732ColorectumMSSlimb development48/3467172/187231.61e-031.46e-0248
GO:00614589EndometriumAEHreproductive system development88/2100427/187239.50e-096.41e-0788
GO:00486089EndometriumAEHreproductive structure development87/2100424/187231.43e-089.12e-0787
GO:00351073EndometriumAEHappendage morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00351083EndometriumAEHlimb morphogenesis29/2100138/187236.06e-045.94e-0329
GO:00487366EndometriumAEHappendage development33/2100172/187231.41e-031.18e-0233
GO:00601736EndometriumAEHlimb development33/2100172/187231.41e-031.18e-0233
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0520221ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
hsa0520231ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HOXA10INCAFBreastDCISASPN,IL15RA,BNC2, etc.9.71e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10ECMBreastHealthyASPN,IL15RA,BNC2, etc.3.40e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFBreastHealthyASPN,IL15RA,BNC2, etc.1.32e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFBreastIDCASPN,IL15RA,BNC2, etc.5.49e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumADJHOXA11,SFRP4,COL1A1, etc.6.29e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumAEHHOXA11,SFRP4,COL1A1, etc.5.96e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumEECHOXA11,SFRP4,COL1A1, etc.4.18e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10FIBEndometriumEECHOXA11,SFRP4,COL1A1, etc.3.61e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10INCAFEndometriumHealthyHOXA11,SFRP4,COL1A1, etc.5.22e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HOXA10MDSCsEsophagusESCCNDUFAF6,PHF1,DYRK4, etc.1.16e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HOXA10insertionFrame_Shift_Insnovelc.974_975insCAAATp.Glu325AspfsTer3p.E325Dfs*3P31260protein_codingTCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.77C>Tp.Ala26Valp.A26VP31260protein_codingdeleterious(0.01)probably_damaging(0.949)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HOXA10SNVMissense_Mutationnovelc.617N>Ap.Ser206Asnp.S206NP31260protein_codingtolerated(0.51)benign(0)TCGA-C5-A902-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
HOXA10SNVMissense_Mutationnovelc.1048G>Ap.Glu350Lysp.E350KP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-VS-A9UU-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HOXA10SNVMissense_Mutationnovelc.498G>Tp.Glu166Aspp.E166DP31260protein_codingdeleterious(0)probably_damaging(0.987)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
HOXA10SNVMissense_Mutationc.1174N>Cp.Lys392Glnp.K392QP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-CK-6746-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1186C>Gp.Arg396Glyp.R396GP31260protein_codingdeleterious(0)probably_damaging(0.995)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1094G>Ap.Arg365Glnp.R365QP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
HOXA10SNVMissense_Mutationc.1079A>Gp.Tyr360Cysp.Y360CP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
HOXA10SNVMissense_Mutationnovelc.1176N>Tp.Lys392Asnp.K392NP31260protein_codingdeleterious(0)probably_damaging(1)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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