Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HORMAD1

Gene summary for HORMAD1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HORMAD1

Gene ID

84072

Gene nameHORMA domain containing 1
Gene AliasCT46
Cytomap1q21.3
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q86X24


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84072HORMAD1P4_cSCCHumanSkincSCC4.93e-061.75e-01-0.00290000000000005
84072HORMAD1P10_cSCCHumanSkincSCC3.57e-196.08e-010.1017
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000081912SkincSCCsister chromatid segregation110/4864202/187235.56e-186.58e-16110
GO:000705912SkincSCCchromosome segregation161/4864346/187238.34e-178.57e-15161
GO:00482854SkincSCCorganelle fission197/4864488/187231.51e-128.36e-11197
GO:009881311SkincSCCnuclear chromosome segregation126/4864281/187234.76e-122.53e-10126
GO:00002803SkincSCCnuclear division178/4864439/187231.17e-115.93e-10178
GO:000170124SkincSCCin utero embryonic development150/4864367/187232.47e-101.04e-08150
GO:00519834SkincSCCregulation of chromosome segregation52/486491/187232.88e-101.20e-0852
GO:0010639111SkincSCCnegative regulation of organelle organization140/4864348/187233.35e-091.15e-07140
GO:190198714SkincSCCregulation of cell cycle phase transition150/4864390/187233.21e-088.61e-07150
GO:000182413SkincSCCblastocyst development53/4864106/187239.74e-082.32e-0653
GO:00517832SkincSCCregulation of nuclear division64/4864139/187232.49e-075.25e-0664
GO:004578613SkincSCCnegative regulation of cell cycle140/4864385/187233.64e-065.50e-05140
GO:00517844SkincSCCnegative regulation of nuclear division30/486456/187239.93e-061.30e-0430
GO:190198812SkincSCCnegative regulation of cell cycle phase transition94/4864249/187232.65e-053.00e-0494
GO:001094812SkincSCCnegative regulation of cell cycle process108/4864294/187232.75e-053.09e-04108
GO:000007512SkincSCCcell cycle checkpoint68/4864169/187233.37e-053.67e-0468
GO:00903054SkincSCCnucleic acid phosphodiester bond hydrolysis97/4864261/187234.08e-054.34e-0497
GO:000706212SkincSCCsister chromatid cohesion30/486462/187231.23e-041.13e-0330
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HORMAD1SNVMissense_Mutationc.1127N>Gp.Ser376Cysp.S376CQ86X24protein_codingdeleterious(0.03)benign(0.007)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
HORMAD1SNVMissense_Mutationnovelc.245T>Cp.Met82Thrp.M82TQ86X24protein_codingdeleterious(0.04)possibly_damaging(0.9)TCGA-BH-A8FZ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HORMAD1SNVMissense_Mutationc.685N>Cp.Glu229Glnp.E229QQ86X24protein_codingdeleterious(0)probably_damaging(0.917)TCGA-D8-A1JA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
HORMAD1SNVMissense_Mutationc.313N>Gp.Pro105Alap.P105AQ86X24protein_codingtolerated(0.07)possibly_damaging(0.824)TCGA-E2-A159-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
HORMAD1SNVMissense_Mutationc.1135N>Cp.Glu379Glnp.E379QQ86X24protein_codingtolerated(0.14)benign(0.04)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
HORMAD1SNVMissense_Mutationnovelc.709N>Ap.Asp237Asnp.D237NQ86X24protein_codingdeleterious(0.03)benign(0.244)TCGA-C5-A7X5-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycarboplatinPD
HORMAD1SNVMissense_Mutationc.1154N>Cp.Arg385Thrp.R385TQ86X24protein_codingdeleterious(0)possibly_damaging(0.691)TCGA-IR-A3LA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HORMAD1SNVMissense_Mutationnovelc.589G>Tp.Asp197Tyrp.D197YQ86X24protein_codingdeleterious(0)possibly_damaging(0.877)TCGA-JW-AAVH-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
HORMAD1SNVMissense_Mutationrs200394759c.253N>Cp.Cys85Argp.C85RQ86X24protein_codingdeleterious(0)probably_damaging(1)TCGA-ZJ-AAXA-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
HORMAD1SNVMissense_Mutationrs774953907c.1072C>Tp.Arg358Trpp.R358WQ86X24protein_codingdeleterious(0.01)possibly_damaging(0.798)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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