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Gene: HNRNPU-AS1 |
Gene summary for HNRNPU-AS1 |
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Gene information | Species | Human | Gene symbol | HNRNPU-AS1 | Gene ID | 3192 |
Gene name | heterogeneous nuclear ribonucleoprotein U | |
Gene Alias | DEE54 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q00839 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3192 | HNRNPU-AS1 | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 3.13e-01 | 0.0875 |
3192 | HNRNPU-AS1 | P2T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.62e-01 | 0.1177 |
3192 | HNRNPU-AS1 | P4T-E | Human | Esophagus | ESCC | 2.90e-03 | 1.50e-01 | 0.1323 |
3192 | HNRNPU-AS1 | P5T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.76e-01 | 0.1327 |
3192 | HNRNPU-AS1 | P8T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.15e-01 | 0.0889 |
3192 | HNRNPU-AS1 | P9T-E | Human | Esophagus | ESCC | 2.79e-12 | 2.90e-01 | 0.1131 |
3192 | HNRNPU-AS1 | P10T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.95e-01 | 0.116 |
3192 | HNRNPU-AS1 | P11T-E | Human | Esophagus | ESCC | 1.72e-04 | 2.22e-01 | 0.1426 |
3192 | HNRNPU-AS1 | P12T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.47e-01 | 0.1122 |
3192 | HNRNPU-AS1 | P15T-E | Human | Esophagus | ESCC | 1.83e-09 | 2.31e-01 | 0.1149 |
3192 | HNRNPU-AS1 | P16T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.98e-01 | 0.1153 |
3192 | HNRNPU-AS1 | P20T-E | Human | Esophagus | ESCC | 6.20e-06 | 1.53e-01 | 0.1124 |
3192 | HNRNPU-AS1 | P21T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.35e-01 | 0.1617 |
3192 | HNRNPU-AS1 | P22T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.26e-01 | 0.1236 |
3192 | HNRNPU-AS1 | P23T-E | Human | Esophagus | ESCC | 7.50e-13 | 3.10e-01 | 0.108 |
3192 | HNRNPU-AS1 | P24T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.22e-02 | 0.1287 |
3192 | HNRNPU-AS1 | P26T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.18e-01 | 0.1276 |
3192 | HNRNPU-AS1 | P27T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.56e-01 | 0.1055 |
3192 | HNRNPU-AS1 | P28T-E | Human | Esophagus | ESCC | 2.27e-21 | 4.11e-01 | 0.1149 |
3192 | HNRNPU-AS1 | P30T-E | Human | Esophagus | ESCC | 4.41e-11 | 5.05e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304042 | Liver | Cyst | Spliceosome | 19/339 | 217/8465 | 1.10e-03 | 1.22e-02 | 1.00e-02 | 19 |
hsa0304052 | Liver | Cyst | Spliceosome | 19/339 | 217/8465 | 1.10e-03 | 1.22e-02 | 1.00e-02 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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