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Gene: HMGXB3 |
Gene summary for HMGXB3 |
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Gene information | Species | Human | Gene symbol | HMGXB3 | Gene ID | 22993 |
Gene name | HMG-box containing 3 | |
Gene Alias | HMGX3 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q12766 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22993 | HMGXB3 | LZE2T | Human | Esophagus | ESCC | 1.64e-02 | 4.76e-01 | 0.082 |
22993 | HMGXB3 | LZE4T | Human | Esophagus | ESCC | 3.98e-07 | 1.24e-01 | 0.0811 |
22993 | HMGXB3 | LZE24T | Human | Esophagus | ESCC | 1.10e-08 | 1.74e-01 | 0.0596 |
22993 | HMGXB3 | LZE21T | Human | Esophagus | ESCC | 9.95e-05 | 2.61e-01 | 0.0655 |
22993 | HMGXB3 | P1T-E | Human | Esophagus | ESCC | 7.36e-05 | 2.57e-01 | 0.0875 |
22993 | HMGXB3 | P2T-E | Human | Esophagus | ESCC | 1.25e-24 | 5.13e-01 | 0.1177 |
22993 | HMGXB3 | P4T-E | Human | Esophagus | ESCC | 1.20e-17 | 3.25e-01 | 0.1323 |
22993 | HMGXB3 | P5T-E | Human | Esophagus | ESCC | 9.26e-25 | 3.29e-01 | 0.1327 |
22993 | HMGXB3 | P8T-E | Human | Esophagus | ESCC | 3.31e-17 | 1.60e-01 | 0.0889 |
22993 | HMGXB3 | P9T-E | Human | Esophagus | ESCC | 3.30e-15 | 1.89e-01 | 0.1131 |
22993 | HMGXB3 | P10T-E | Human | Esophagus | ESCC | 4.16e-21 | 2.43e-01 | 0.116 |
22993 | HMGXB3 | P11T-E | Human | Esophagus | ESCC | 1.03e-22 | 6.67e-01 | 0.1426 |
22993 | HMGXB3 | P12T-E | Human | Esophagus | ESCC | 2.41e-20 | 2.68e-01 | 0.1122 |
22993 | HMGXB3 | P15T-E | Human | Esophagus | ESCC | 4.91e-19 | 3.72e-01 | 0.1149 |
22993 | HMGXB3 | P16T-E | Human | Esophagus | ESCC | 1.58e-18 | 3.36e-01 | 0.1153 |
22993 | HMGXB3 | P17T-E | Human | Esophagus | ESCC | 1.08e-07 | 4.57e-01 | 0.1278 |
22993 | HMGXB3 | P19T-E | Human | Esophagus | ESCC | 1.24e-03 | 3.67e-01 | 0.1662 |
22993 | HMGXB3 | P20T-E | Human | Esophagus | ESCC | 3.52e-07 | 1.20e-01 | 0.1124 |
22993 | HMGXB3 | P21T-E | Human | Esophagus | ESCC | 4.39e-21 | 3.05e-01 | 0.1617 |
22993 | HMGXB3 | P22T-E | Human | Esophagus | ESCC | 2.00e-23 | 3.96e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMGXB3 | SNV | Missense_Mutation | c.2199C>G | p.Ile733Met | p.I733M | Q12766 | protein_coding | tolerated(0.11) | benign(0.172) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
HMGXB3 | SNV | Missense_Mutation | c.2860N>C | p.Val954Leu | p.V954L | Q12766 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
HMGXB3 | SNV | Missense_Mutation | novel | c.2897C>T | p.Ala966Val | p.A966V | Q12766 | protein_coding | tolerated(0.08) | benign(0.162) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HMGXB3 | SNV | Missense_Mutation | c.3244C>T | p.Arg1082Cys | p.R1082C | Q12766 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HMGXB3 | SNV | Missense_Mutation | c.1919N>A | p.Arg640Gln | p.R640Q | Q12766 | protein_coding | tolerated(0.28) | benign(0.015) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HMGXB3 | SNV | Missense_Mutation | c.1262N>G | p.Ser421Cys | p.S421C | Q12766 | protein_coding | tolerated(0.05) | probably_damaging(0.996) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
HMGXB3 | SNV | Missense_Mutation | c.3118G>A | p.Glu1040Lys | p.E1040K | Q12766 | protein_coding | tolerated(0.14) | benign(0.314) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
HMGXB3 | SNV | Missense_Mutation | c.3020N>A | p.Ser1007Asn | p.S1007N | Q12766 | protein_coding | tolerated(0.07) | benign(0.215) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HMGXB3 | SNV | Missense_Mutation | rs753841260 | c.2176G>A | p.Val726Met | p.V726M | Q12766 | protein_coding | tolerated(0.15) | benign(0.053) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
HMGXB3 | SNV | Missense_Mutation | c.2206A>C | p.Thr736Pro | p.T736P | Q12766 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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