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Gene: HMGN1 |
Gene summary for HMGN1 |
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Gene information | Species | Human | Gene symbol | HMGN1 | Gene ID | 3150 |
Gene name | high mobility group nucleosome binding domain 1 | |
Gene Alias | HMG14 | |
Cytomap | 21q22.2 | |
Gene Type | protein-coding | GO ID | GO:0000720 | UniProtAcc | P05114 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3150 | HMGN1 | GSM4909280 | Human | Breast | Precancer | 9.04e-04 | -6.72e-01 | 0.0305 |
3150 | HMGN1 | GSM4909281 | Human | Breast | IDC | 5.21e-27 | 4.48e-01 | 0.21 |
3150 | HMGN1 | GSM4909282 | Human | Breast | IDC | 1.78e-06 | 2.89e-01 | -0.0288 |
3150 | HMGN1 | GSM4909285 | Human | Breast | IDC | 3.85e-70 | 6.51e-01 | 0.21 |
3150 | HMGN1 | GSM4909286 | Human | Breast | IDC | 2.27e-02 | 9.48e-02 | 0.1081 |
3150 | HMGN1 | GSM4909287 | Human | Breast | IDC | 6.22e-09 | 1.28e-01 | 0.2057 |
3150 | HMGN1 | GSM4909288 | Human | Breast | IDC | 3.86e-08 | 2.51e-01 | 0.0988 |
3150 | HMGN1 | GSM4909290 | Human | Breast | IDC | 2.66e-09 | 3.27e-01 | 0.2096 |
3150 | HMGN1 | GSM4909293 | Human | Breast | IDC | 2.59e-26 | 4.53e-01 | 0.1581 |
3150 | HMGN1 | GSM4909294 | Human | Breast | IDC | 1.94e-44 | 4.40e-01 | 0.2022 |
3150 | HMGN1 | GSM4909296 | Human | Breast | IDC | 1.10e-10 | -1.82e-01 | 0.1524 |
3150 | HMGN1 | GSM4909297 | Human | Breast | IDC | 3.68e-26 | -2.88e-01 | 0.1517 |
3150 | HMGN1 | GSM4909298 | Human | Breast | IDC | 3.69e-08 | 3.36e-01 | 0.1551 |
3150 | HMGN1 | GSM4909301 | Human | Breast | IDC | 1.04e-14 | -4.21e-01 | 0.1577 |
3150 | HMGN1 | GSM4909304 | Human | Breast | IDC | 5.64e-13 | -4.68e-01 | 0.1636 |
3150 | HMGN1 | GSM4909308 | Human | Breast | IDC | 1.90e-20 | 4.02e-01 | 0.158 |
3150 | HMGN1 | GSM4909309 | Human | Breast | IDC | 2.50e-03 | 8.45e-03 | 0.0483 |
3150 | HMGN1 | GSM4909311 | Human | Breast | IDC | 2.22e-54 | -3.59e-01 | 0.1534 |
3150 | HMGN1 | GSM4909312 | Human | Breast | IDC | 2.88e-25 | 3.04e-01 | 0.1552 |
3150 | HMGN1 | GSM4909313 | Human | Breast | IDC | 2.27e-04 | 1.12e-01 | 0.0391 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
GO:00093148 | Breast | Precancer | response to radiation | 47/1080 | 456/18723 | 8.39e-05 | 1.62e-03 | 47 |
GO:00506786 | Breast | Precancer | regulation of epithelial cell proliferation | 40/1080 | 381/18723 | 1.88e-04 | 3.03e-03 | 40 |
GO:000931412 | Breast | IDC | response to radiation | 62/1434 | 456/18723 | 6.91e-06 | 2.10e-04 | 62 |
GO:005067313 | Breast | IDC | epithelial cell proliferation | 60/1434 | 437/18723 | 7.13e-06 | 2.15e-04 | 60 |
GO:005067812 | Breast | IDC | regulation of epithelial cell proliferation | 54/1434 | 381/18723 | 8.07e-06 | 2.39e-04 | 54 |
GO:000931422 | Breast | DCIS | response to radiation | 62/1390 | 456/18723 | 2.56e-06 | 8.87e-05 | 62 |
GO:005067322 | Breast | DCIS | epithelial cell proliferation | 57/1390 | 437/18723 | 2.22e-05 | 5.23e-04 | 57 |
GO:005067821 | Breast | DCIS | regulation of epithelial cell proliferation | 51/1390 | 381/18723 | 2.96e-05 | 6.55e-04 | 51 |
GO:00094111 | Breast | DCIS | response to UV | 20/1390 | 149/18723 | 7.13e-03 | 4.85e-02 | 20 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00506787 | Cervix | CC | regulation of epithelial cell proliferation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00094112 | Cervix | CC | response to UV | 33/2311 | 149/18723 | 5.51e-04 | 5.29e-03 | 33 |
GO:00097915 | Cervix | CC | post-embryonic development | 20/2311 | 80/18723 | 1.40e-03 | 1.10e-02 | 20 |
GO:0150063 | Cervix | CC | visual system development | 63/2311 | 375/18723 | 6.58e-03 | 3.65e-02 | 63 |
GO:00063545 | Cervix | CC | DNA-templated transcription, elongation | 20/2311 | 91/18723 | 6.88e-03 | 3.74e-02 | 20 |
GO:0001654 | Cervix | CC | eye development | 62/2311 | 371/18723 | 7.83e-03 | 4.13e-02 | 62 |
GO:0048880 | Cervix | CC | sensory system development | 63/2311 | 381/18723 | 9.29e-03 | 4.66e-02 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMGN1 | SNV | Missense_Mutation | rs778772049 | c.201C>A | p.Asn67Lys | p.N67K | P05114 | protein_coding | tolerated(0.19) | possibly_damaging(0.636) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
HMGN1 | SNV | Missense_Mutation | c.28N>A | p.Glu10Lys | p.E10K | P05114 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HMGN1 | SNV | Missense_Mutation | rs547753128 | c.242N>T | p.Thr81Met | p.T81M | P05114 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HMGN1 | SNV | Missense_Mutation | c.28G>A | p.Glu10Lys | p.E10K | P05114 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-55-A492-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HMGN1 | SNV | Missense_Mutation | novel | c.139G>C | p.Asp47His | p.D47H | P05114 | protein_coding | deleterious(0.01) | possibly_damaging(0.726) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
HMGN1 | SNV | Missense_Mutation | novel | c.115N>A | p.Ala39Thr | p.A39T | P05114 | protein_coding | tolerated(0.18) | possibly_damaging(0.825) | TCGA-LA-A446-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HMGN1 | SNV | Missense_Mutation | c.28N>A | p.Glu10Lys | p.E10K | P05114 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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