Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00022629 | Breast | Precancer | myeloid cell homeostasis | 27/1080 | 157/18723 | 3.10e-07 | 1.49e-05 | 27 |
GO:00432808 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/1080 | 129/18723 | 3.13e-07 | 1.50e-05 | 24 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00109509 | Breast | Precancer | positive regulation of endopeptidase activity | 29/1080 | 179/18723 | 4.23e-07 | 1.90e-05 | 29 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00511019 | Breast | Precancer | regulation of DNA binding | 22/1080 | 118/18723 | 9.28e-07 | 3.71e-05 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HMGB1 | SNV | Missense_Mutation | | c.120N>C | p.Glu40Asp | p.E40D | P09429 | protein_coding | deleterious(0.02) | benign(0.105) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
HMGB1 | SNV | Missense_Mutation | | c.131A>C | p.Lys44Thr | p.K44T | P09429 | protein_coding | deleterious(0.02) | possibly_damaging(0.784) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | | c.624A>T | p.Glu208Asp | p.E208D | P09429 | protein_coding | tolerated_low_confidence(0.26) | benign(0) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | | c.443C>G | p.Ala148Gly | p.A148G | P09429 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
HMGB1 | SNV | Missense_Mutation | novel | c.377C>T | p.Ala126Val | p.A126V | P09429 | protein_coding | deleterious(0.03) | benign(0.221) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | novel | c.168G>T | p.Glu56Asp | p.E56D | P09429 | protein_coding | deleterious(0.04) | benign(0.105) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
HMGB1 | SNV | Missense_Mutation | | c.253N>G | p.Thr85Ala | p.T85A | P09429 | protein_coding | tolerated(0.15) | benign(0.009) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | novel | c.23N>G | p.Lys8Arg | p.K8R | P09429 | protein_coding | deleterious(0.02) | benign(0.358) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | novel | c.25N>T | p.Pro9Ser | p.P9S | P09429 | protein_coding | deleterious(0.04) | possibly_damaging(0.573) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HMGB1 | SNV | Missense_Mutation | | c.488G>A | p.Arg163Gln | p.R163Q | P09429 | protein_coding | tolerated(0.16) | benign(0.193) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | PREDNISOLONE | PREDNISOLONE | 18447956 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | AUTOLOGOUS DENDRITIC CELLS | | 16997859 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | ADJUVANT | | 15161015 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | SALINE | SODIUM CHLORIDE | 17334244 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | DISTAMYCIN | | 9161031 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | GP100 | | 16968820 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | CHLORAMPHENICOL | CHLORAMPHENICOL | 9931456 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | EGCG | EPIGALOCATECHIN GALLATE | 17987129 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | MART1 | | 16968820 |
3146 | HMGB1 | DRUGGABLE GENOME, CELL SURFACE, TRANSCRIPTION FACTOR | | AMPICILLIN | AMPICILLIN | 9931456 |