Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: HIVEP3

Gene summary for HIVEP3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HIVEP3

Gene ID

59269

Gene nameHIVEP zinc finger 3
Gene AliasKBP-1
Cytomap1p34.2
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q5T1R4


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
59269HIVEP3CCI_1HumanCervixCC2.53e-056.84e-010.528
59269HIVEP3CCI_3HumanCervixCC2.02e-148.87e-010.516
59269HIVEP3CCII_1HumanCervixCC1.13e-022.04e-010.3249
59269HIVEP3LZE8THumanEsophagusESCC3.59e-042.32e-010.067
59269HIVEP3P1T-EHumanEsophagusESCC1.20e-043.39e-010.0875
59269HIVEP3P2T-EHumanEsophagusESCC3.05e-071.06e-010.1177
59269HIVEP3P8T-EHumanEsophagusESCC4.15e-031.40e-010.0889
59269HIVEP3P10T-EHumanEsophagusESCC9.62e-063.45e-020.116
59269HIVEP3P12T-EHumanEsophagusESCC3.00e-067.81e-020.1122
59269HIVEP3P15T-EHumanEsophagusESCC1.00e-021.09e-010.1149
59269HIVEP3P16T-EHumanEsophagusESCC4.93e-124.27e-010.1153
59269HIVEP3P20T-EHumanEsophagusESCC2.26e-041.89e-010.1124
59269HIVEP3P21T-EHumanEsophagusESCC3.73e-072.18e-010.1617
59269HIVEP3P23T-EHumanEsophagusESCC2.10e-081.13e-010.108
59269HIVEP3P26T-EHumanEsophagusESCC2.85e-106.09e-020.1276
59269HIVEP3P27T-EHumanEsophagusESCC1.70e-158.90e-020.1055
59269HIVEP3P30T-EHumanEsophagusESCC1.50e-041.32e-010.137
59269HIVEP3P31T-EHumanEsophagusESCC3.32e-031.97e-010.1251
59269HIVEP3P32T-EHumanEsophagusESCC1.53e-111.67e-010.1666
59269HIVEP3P36T-EHumanEsophagusESCC1.10e-051.74e-010.1187
Page: 1 2 3 4 5 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00605375CervixCCmuscle tissue development76/2311403/187239.76e-051.27e-0376
GO:00147064CervixCCstriated muscle tissue development72/2311384/187231.76e-042.07e-0372
GO:00075173CervixCCmuscle organ development58/2311327/187232.73e-031.85e-0258
GO:00075192CervixCCskeletal muscle tissue development30/2311155/187237.97e-034.18e-0230
GO:006053716EsophagusESCCmuscle tissue development211/8552403/187233.84e-031.56e-02211
GO:001470615EsophagusESCCstriated muscle tissue development197/8552384/187231.46e-024.74e-02197
GO:00605373LungIACmuscle tissue development61/2061403/187236.24e-034.48e-0261
GO:00605371LungAISmuscle tissue development58/1849403/187232.22e-032.37e-0258
GO:0060538LungAAHskeletal muscle organ development14/613166/187231.15e-033.33e-0214
GO:0007517LungAAHmuscle organ development22/613327/187231.20e-033.33e-0222
GO:0007519LungAAHskeletal muscle tissue development13/613155/187231.79e-034.22e-0213
GO:00605372LungAAHmuscle tissue development25/613403/187231.79e-034.22e-0225
GO:00605378Oral cavityOSCCmuscle tissue development185/7305403/187232.60e-031.14e-02185
GO:00147067Oral cavityOSCCstriated muscle tissue development174/7305384/187236.45e-032.40e-02174
GO:006053715Oral cavityEOLPmuscle tissue development77/2218403/187231.37e-052.31e-0477
GO:001470614Oral cavityEOLPstriated muscle tissue development72/2218384/187234.87e-056.43e-0472
GO:00605384Oral cavityEOLPskeletal muscle organ development35/2218166/187234.65e-044.08e-0335
GO:00075195Oral cavityEOLPskeletal muscle tissue development32/2218155/187231.15e-038.37e-0332
GO:00075176Oral cavityEOLPmuscle organ development57/2218327/187231.76e-031.15e-0257
GO:006053723Oral cavityNEOLPmuscle tissue development75/2005403/187231.22e-063.15e-0575
Page: 1 2 3 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HIVEP3IMGOBColorectumADJGRAMD1B,ABCA5,LINC00278, etc.9.63e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3IMENTColorectumCRCGRAMD1B,ABCA5,LINC00278, etc.6.57e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3GOBColorectumCRCGRAMD1B,ABCA5,LINC00278, etc.4.11e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3PLAEndometriumHealthyTAF4B,POLR3C,PARD6B, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3CD8TEXINTEndometriumHealthyTAF4B,POLR3C,PARD6B, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3NKLungIACAP005482.1,SLC16A1-AS1,AC243829.2, etc.4.35e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3MEGAPancreasPDACARL8B,AC026202.2,DCBLD2, etc.5.47e-05The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3MSCPancreasPDACARL8B,AC026202.2,DCBLD2, etc.1.30e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3LYMENDPancreasPDACARL8B,AC026202.2,DCBLD2, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HIVEP3APCAFPancreasPDACARL8B,AC026202.2,DCBLD2, etc.2.70e-04The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 2 3 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HIVEP3SNVMissense_Mutationrs751390922c.1754N>Ap.Arg585Glnp.R585QQ5T1R4protein_codingdeleterious(0)probably_damaging(0.992)TCGA-A2-A0YM-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIVEP3SNVMissense_Mutationc.5599G>Cp.Glu1867Glnp.E1867QQ5T1R4protein_codingdeleterious_low_confidence(0.02)probably_damaging(0.965)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HIVEP3SNVMissense_Mutationc.3122G>Cp.Arg1041Thrp.R1041TQ5T1R4protein_codingdeleterious(0)probably_damaging(0.941)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HIVEP3SNVMissense_Mutationc.2695G>Cp.Glu899Glnp.E899QQ5T1R4protein_codingdeleterious(0)probably_damaging(0.994)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HIVEP3SNVMissense_Mutationc.1879G>Ap.Glu627Lysp.E627KQ5T1R4protein_codingtolerated(0.15)benign(0.078)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
HIVEP3SNVMissense_Mutationnovelc.6675C>Ap.Phe2225Leup.F2225LQ5T1R4protein_codingdeleterious_low_confidence(0.01)benign(0.056)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIVEP3SNVMissense_Mutationrs560610413c.964G>Ap.Glu322Lysp.E322KQ5T1R4protein_codingtolerated(0.05)benign(0.122)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HIVEP3SNVMissense_Mutationc.3149N>Tp.Ser1050Phep.S1050FQ5T1R4protein_codingdeleterious(0)probably_damaging(0.996)TCGA-AO-A03V-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
HIVEP3SNVMissense_Mutationc.4310N>Tp.Ser1437Ilep.S1437IQ5T1R4protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AO-A0J6-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
HIVEP3SNVMissense_Mutationrs377282990c.6232N>Ap.Glu2078Lysp.E2078KQ5T1R4protein_codingtolerated(0.57)benign(0.073)TCGA-B6-A0I8-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1