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Gene: HIST2H2AA4 |
Gene summary for HIST2H2AA4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HIST2H2AA4 | Gene ID | 723790 |
| Gene name | H2A clustered histone 19 | |
| Gene Alias | H2A/R | |
| Cytomap | 1q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6FI13 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 723790 | HIST2H2AA4 | LZE4T | Human | Esophagus | ESCC | 3.18e-05 | 1.93e-01 | 0.0811 |
| 723790 | HIST2H2AA4 | LZE5T | Human | Esophagus | ESCC | 1.28e-07 | 4.41e-01 | 0.0514 |
| 723790 | HIST2H2AA4 | LZE7T | Human | Esophagus | ESCC | 2.56e-05 | 3.18e-01 | 0.0667 |
| 723790 | HIST2H2AA4 | LZE20T | Human | Esophagus | ESCC | 1.65e-20 | 7.04e-01 | 0.0662 |
| 723790 | HIST2H2AA4 | LZE21D1 | Human | Esophagus | HGIN | 1.52e-08 | 1.02e+00 | 0.0632 |
| 723790 | HIST2H2AA4 | LZE22D1 | Human | Esophagus | HGIN | 2.58e-11 | 4.57e-01 | 0.0595 |
| 723790 | HIST2H2AA4 | LZE22T | Human | Esophagus | ESCC | 1.15e-08 | 7.37e-01 | 0.068 |
| 723790 | HIST2H2AA4 | LZE24T | Human | Esophagus | ESCC | 3.74e-07 | 2.19e-01 | 0.0596 |
| 723790 | HIST2H2AA4 | LZE22D3 | Human | Esophagus | HGIN | 1.73e-02 | 4.41e-01 | 0.0653 |
| 723790 | HIST2H2AA4 | P1T-E | Human | Esophagus | ESCC | 1.67e-28 | 1.36e+00 | 0.0875 |
| 723790 | HIST2H2AA4 | P2T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.09e-01 | 0.1177 |
| 723790 | HIST2H2AA4 | P4T-E | Human | Esophagus | ESCC | 3.48e-08 | 2.29e-01 | 0.1323 |
| 723790 | HIST2H2AA4 | P5T-E | Human | Esophagus | ESCC | 9.02e-11 | 2.52e-01 | 0.1327 |
| 723790 | HIST2H2AA4 | P8T-E | Human | Esophagus | ESCC | 1.47e-14 | 3.27e-01 | 0.0889 |
| 723790 | HIST2H2AA4 | P9T-E | Human | Esophagus | ESCC | 5.60e-20 | 4.19e-01 | 0.1131 |
| 723790 | HIST2H2AA4 | P10T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.10e-01 | 0.116 |
| 723790 | HIST2H2AA4 | P11T-E | Human | Esophagus | ESCC | 7.73e-16 | 6.41e-01 | 0.1426 |
| 723790 | HIST2H2AA4 | P12T-E | Human | Esophagus | ESCC | 3.02e-26 | 5.00e-01 | 0.1122 |
| 723790 | HIST2H2AA4 | P15T-E | Human | Esophagus | ESCC | 3.12e-08 | 2.14e-01 | 0.1149 |
| 723790 | HIST2H2AA4 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.07e-01 | 0.1153 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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