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Gene: HIST1H4H |
Gene summary for HIST1H4H |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HIST1H4H | Gene ID | 8365 |
| Gene name | H4 clustered histone 8 | |
| Gene Alias | H4-16 | |
| Cytomap | 6p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | B2R4R0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8365 | HIST1H4H | CCI_2 | Human | Cervix | CC | 1.21e-16 | 1.01e+00 | 0.5249 |
| 8365 | HIST1H4H | CCI_3 | Human | Cervix | CC | 1.51e-04 | 2.20e-01 | 0.516 |
| 8365 | HIST1H4H | Tumor | Human | Cervix | CC | 3.63e-03 | 1.14e-01 | 0.1241 |
| 8365 | HIST1H4H | LZE4T | Human | Esophagus | ESCC | 5.80e-05 | 2.54e-01 | 0.0811 |
| 8365 | HIST1H4H | LZE5T | Human | Esophagus | ESCC | 5.73e-07 | 5.91e-01 | 0.0514 |
| 8365 | HIST1H4H | LZE20T | Human | Esophagus | ESCC | 2.64e-09 | 4.38e-01 | 0.0662 |
| 8365 | HIST1H4H | LZE22T | Human | Esophagus | ESCC | 4.69e-07 | 5.45e-01 | 0.068 |
| 8365 | HIST1H4H | LZE24T | Human | Esophagus | ESCC | 1.61e-16 | 6.67e-01 | 0.0596 |
| 8365 | HIST1H4H | LZE21T | Human | Esophagus | ESCC | 1.47e-05 | 5.31e-01 | 0.0655 |
| 8365 | HIST1H4H | P1T-E | Human | Esophagus | ESCC | 1.10e-15 | 1.08e+00 | 0.0875 |
| 8365 | HIST1H4H | P2T-E | Human | Esophagus | ESCC | 2.89e-28 | 5.42e-01 | 0.1177 |
| 8365 | HIST1H4H | P4T-E | Human | Esophagus | ESCC | 6.02e-14 | 4.81e-01 | 0.1323 |
| 8365 | HIST1H4H | P8T-E | Human | Esophagus | ESCC | 1.18e-15 | 3.52e-01 | 0.0889 |
| 8365 | HIST1H4H | P9T-E | Human | Esophagus | ESCC | 1.88e-12 | 4.46e-01 | 0.1131 |
| 8365 | HIST1H4H | P10T-E | Human | Esophagus | ESCC | 3.58e-28 | 5.63e-01 | 0.116 |
| 8365 | HIST1H4H | P12T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.57e-01 | 0.1122 |
| 8365 | HIST1H4H | P15T-E | Human | Esophagus | ESCC | 5.98e-10 | 4.36e-01 | 0.1149 |
| 8365 | HIST1H4H | P16T-E | Human | Esophagus | ESCC | 1.63e-03 | 1.34e-01 | 0.1153 |
| 8365 | HIST1H4H | P17T-E | Human | Esophagus | ESCC | 1.25e-04 | 5.93e-01 | 0.1278 |
| 8365 | HIST1H4H | P20T-E | Human | Esophagus | ESCC | 4.51e-47 | 1.73e+00 | 0.1124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HIST1H4H | SNV | Missense_Mutation | novel | c.125N>A | p.Gly42Asp | p.G42D | P62805 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
| HIST1H4H | SNV | Missense_Mutation | c.23N>A | p.Gly8Glu | p.G8E | P62805 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.932) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HIST1H4H | deletion | Frame_Shift_Del | novel | c.216_219delTTAC | p.Tyr73GlnfsTer9 | p.Y73Qfs*9 | P62805 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
| HIST1H4H | insertion | Frame_Shift_Ins | novel | c.68_69insT | p.Leu23PhefsTer4 | p.L23Ffs*4 | P62805 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
| HIST1H4H | SNV | Missense_Mutation | novel | c.40G>A | p.Gly14Arg | p.G14R | P62805 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
| HIST1H4H | SNV | Missense_Mutation | novel | c.223N>C | p.Glu75Gln | p.E75Q | P62805 | protein_coding | deleterious(0.03) | probably_damaging(0.976) | TCGA-B5-A3S1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | SD |
| HIST1H4H | SNV | Missense_Mutation | rs752058100 | c.16N>G | p.Lys6Glu | p.K6E | P62805 | protein_coding | deleterious_low_confidence(0.01) | benign(0.151) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| HIST1H4H | SNV | Missense_Mutation | rs769287159 | c.115N>A | p.Ala39Thr | p.A39T | P62805 | protein_coding | deleterious(0.01) | possibly_damaging(0.75) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| HIST1H4H | SNV | Missense_Mutation | rs766453964 | c.91N>G | p.Thr31Ala | p.T31A | P62805 | protein_coding | deleterious(0.03) | possibly_damaging(0.764) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| HIST1H4H | SNV | Missense_Mutation | novel | c.55C>T | p.His19Tyr | p.H19Y | P62805 | protein_coding | deleterious(0.03) | benign(0.101) | TCGA-56-A4BX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | chemo | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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