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Gene: HIST1H4C |
Gene summary for HIST1H4C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HIST1H4C | Gene ID | 8364 |
| Gene name | H4 clustered histone 3 | |
| Gene Alias | H4-16 | |
| Cytomap | 6p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | B2R4R0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8364 | HIST1H4C | GSM4909282 | Human | Breast | IDC | 1.61e-46 | 1.10e+00 | -0.0288 |
| 8364 | HIST1H4C | GSM4909286 | Human | Breast | IDC | 1.85e-18 | 5.37e-01 | 0.1081 |
| 8364 | HIST1H4C | GSM4909290 | Human | Breast | IDC | 2.48e-04 | 4.58e-01 | 0.2096 |
| 8364 | HIST1H4C | GSM4909291 | Human | Breast | IDC | 2.09e-02 | 4.41e-01 | 0.1753 |
| 8364 | HIST1H4C | GSM4909296 | Human | Breast | IDC | 1.24e-05 | 2.15e-01 | 0.1524 |
| 8364 | HIST1H4C | GSM4909297 | Human | Breast | IDC | 2.92e-02 | -8.97e-02 | 0.1517 |
| 8364 | HIST1H4C | GSM4909301 | Human | Breast | IDC | 2.68e-05 | 3.97e-01 | 0.1577 |
| 8364 | HIST1H4C | GSM4909311 | Human | Breast | IDC | 2.18e-12 | -9.98e-02 | 0.1534 |
| 8364 | HIST1H4C | GSM4909312 | Human | Breast | IDC | 1.25e-03 | 1.69e-01 | 0.1552 |
| 8364 | HIST1H4C | GSM4909319 | Human | Breast | IDC | 2.61e-27 | 2.82e-01 | 0.1563 |
| 8364 | HIST1H4C | GSM4909321 | Human | Breast | IDC | 6.04e-08 | -3.20e-01 | 0.1559 |
| 8364 | HIST1H4C | brca10 | Human | Breast | Precancer | 9.87e-06 | -3.41e-01 | -0.0029 |
| 8364 | HIST1H4C | M1 | Human | Breast | IDC | 3.51e-12 | 5.68e-01 | 0.1577 |
| 8364 | HIST1H4C | NCCBC14 | Human | Breast | DCIS | 1.59e-05 | 3.67e-02 | 0.2021 |
| 8364 | HIST1H4C | NCCBC3 | Human | Breast | DCIS | 6.11e-05 | 3.23e-01 | 0.1198 |
| 8364 | HIST1H4C | NCCBC5 | Human | Breast | DCIS | 1.44e-02 | -7.73e-02 | 0.2046 |
| 8364 | HIST1H4C | P1 | Human | Breast | IDC | 4.35e-13 | 2.68e-01 | 0.1527 |
| 8364 | HIST1H4C | DCIS2 | Human | Breast | DCIS | 2.77e-28 | -7.12e-02 | 0.0085 |
| 8364 | HIST1H4C | CCI_2 | Human | Cervix | CC | 8.30e-15 | 7.06e-01 | 0.5249 |
| 8364 | HIST1H4C | CCI_3 | Human | Cervix | CC | 7.43e-04 | 2.06e-01 | 0.516 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| hsa053221 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HIST1H4C | SNV | Missense_Mutation | c.31N>A | p.Leu11Met | p.L11M | P62805 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.456) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| HIST1H4C | SNV | Missense_Mutation | c.135G>C | p.Lys45Asn | p.K45N | P62805 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.79) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| HIST1H4C | SNV | Missense_Mutation | novel | c.250G>A | p.Ala84Thr | p.A84T | P62805 | protein_coding | tolerated(0.07) | benign(0.094) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HIST1H4C | SNV | Missense_Mutation | novel | c.157G>C | p.Glu53Gln | p.E53Q | P62805 | protein_coding | deleterious(0.02) | possibly_damaging(0.667) | TCGA-DI-A1NO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
| HIST1H4C | SNV | Missense_Mutation | novel | c.118C>G | p.Arg40Gly | p.R40G | P62805 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BC-A8YO-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
| HIST1H4C | SNV | Missense_Mutation | c.266A>G | p.Tyr89Cys | p.Y89C | P62805 | protein_coding | deleterious(0.04) | benign(0.395) | TCGA-CC-A7IJ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| HIST1H4C | SNV | Missense_Mutation | c.73G>A | p.Asp25Asn | p.D25N | P62805 | protein_coding | tolerated_low_confidence(0.05) | benign(0.243) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
| HIST1H4C | SNV | Missense_Mutation | novel | c.299N>T | p.Gly100Val | p.G100V | P62805 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.983) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| HIST1H4C | SNV | Missense_Mutation | c.195N>A | p.Asn65Lys | p.N65K | P62805 | protein_coding | deleterious(0) | benign(0.198) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
| HIST1H4C | SNV | Missense_Mutation | c.70C>T | p.Arg24Trp | p.R24W | P62805 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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