![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HIST1H3J |
Gene summary for HIST1H3J |
![]() |
Gene information | Species | Human | Gene symbol | HIST1H3J | Gene ID | 8356 |
Gene name | H3 clustered histone 12 | |
Gene Alias | H3/j | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | P68431 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8356 | HIST1H3J | AEH-subject1 | Human | Endometrium | AEH | 1.54e-39 | 8.13e-01 | -0.3059 |
8356 | HIST1H3J | AEH-subject2 | Human | Endometrium | AEH | 1.29e-22 | 5.93e-01 | -0.2525 |
8356 | HIST1H3J | AEH-subject3 | Human | Endometrium | AEH | 6.47e-18 | 6.02e-01 | -0.2576 |
8356 | HIST1H3J | AEH-subject4 | Human | Endometrium | AEH | 1.56e-05 | 2.15e-01 | -0.2657 |
8356 | HIST1H3J | EEC-subject2 | Human | Endometrium | EEC | 2.17e-15 | 4.22e-01 | -0.2607 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H3J | SNV | Missense_Mutation | c.83N>G | p.Lys28Arg | p.K28R | P68431 | protein_coding | deleterious_low_confidence(0.03) | benign(0.044) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HIST1H3J | insertion | Nonsense_Mutation | novel | c.278_279insATGATTGCACAATTGCACTCCAGCCTGGGTGACAGA | p.Leu93_Gln94insTer | p.L93_Q94ins* | P68431 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
HIST1H3J | SNV | Missense_Mutation | c.22N>T | p.Ala8Ser | p.A8S | P68431 | protein_coding | deleterious_low_confidence(0.03) | benign(0.021) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
HIST1H3J | SNV | Missense_Mutation | novel | c.292N>A | p.Glu98Lys | p.E98K | P68431 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.904) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H3J | SNV | Missense_Mutation | c.226N>A | p.Ala76Thr | p.A76T | P68431 | protein_coding | deleterious_low_confidence(0.02) | benign(0.348) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
HIST1H3J | SNV | Missense_Mutation | novel | c.161N>A | p.Arg54His | p.R54H | P68431 | protein_coding | tolerated_low_confidence(0.05) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIST1H3J | SNV | Missense_Mutation | c.275N>T | p.Ala92Val | p.A92V | P68431 | protein_coding | deleterious_low_confidence(0) | benign(0.117) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HIST1H3J | SNV | Missense_Mutation | c.319N>T | p.Asp107Tyr | p.D107Y | P68431 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
HIST1H3J | SNV | Missense_Mutation | c.386G>A | p.Arg129His | p.R129H | P68431 | protein_coding | deleterious_low_confidence(0.04) | benign(0.072) | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H3J | SNV | Missense_Mutation | c.146N>C | p.Leu49Ser | p.L49S | P68431 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.983) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |