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Gene: HIST1H2AE |
Gene summary for HIST1H2AE |
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Gene information | Species | Human | Gene symbol | HIST1H2AE | Gene ID | 3012 |
Gene name | H2A clustered histone 8 | |
Gene Alias | H2A.1 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P04908 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3012 | HIST1H2AE | LZE20T | Human | Esophagus | ESCC | 4.97e-05 | 2.69e-01 | 0.0662 |
3012 | HIST1H2AE | LZE22T | Human | Esophagus | ESCC | 2.25e-02 | 1.59e-01 | 0.068 |
3012 | HIST1H2AE | LZE24T | Human | Esophagus | ESCC | 8.36e-09 | 3.46e-01 | 0.0596 |
3012 | HIST1H2AE | P1T-E | Human | Esophagus | ESCC | 1.04e-24 | 1.24e+00 | 0.0875 |
3012 | HIST1H2AE | P2T-E | Human | Esophagus | ESCC | 5.33e-12 | 2.69e-01 | 0.1177 |
3012 | HIST1H2AE | P4T-E | Human | Esophagus | ESCC | 1.03e-04 | 2.16e-01 | 0.1323 |
3012 | HIST1H2AE | P8T-E | Human | Esophagus | ESCC | 2.60e-11 | 1.67e-01 | 0.0889 |
3012 | HIST1H2AE | P9T-E | Human | Esophagus | ESCC | 2.31e-08 | 2.09e-01 | 0.1131 |
3012 | HIST1H2AE | P10T-E | Human | Esophagus | ESCC | 3.60e-17 | 4.43e-01 | 0.116 |
3012 | HIST1H2AE | P12T-E | Human | Esophagus | ESCC | 2.61e-17 | 4.30e-01 | 0.1122 |
3012 | HIST1H2AE | P15T-E | Human | Esophagus | ESCC | 5.01e-09 | 1.40e-01 | 0.1149 |
3012 | HIST1H2AE | P16T-E | Human | Esophagus | ESCC | 1.15e-10 | 1.15e-01 | 0.1153 |
3012 | HIST1H2AE | P20T-E | Human | Esophagus | ESCC | 1.18e-27 | 8.28e-01 | 0.1124 |
3012 | HIST1H2AE | P22T-E | Human | Esophagus | ESCC | 3.86e-25 | 5.63e-01 | 0.1236 |
3012 | HIST1H2AE | P23T-E | Human | Esophagus | ESCC | 2.71e-07 | 3.56e-01 | 0.108 |
3012 | HIST1H2AE | P24T-E | Human | Esophagus | ESCC | 3.46e-04 | 1.03e-01 | 0.1287 |
3012 | HIST1H2AE | P26T-E | Human | Esophagus | ESCC | 1.71e-25 | 6.21e-01 | 0.1276 |
3012 | HIST1H2AE | P27T-E | Human | Esophagus | ESCC | 3.93e-11 | 3.38e-01 | 0.1055 |
3012 | HIST1H2AE | P28T-E | Human | Esophagus | ESCC | 1.31e-02 | 4.91e-02 | 0.1149 |
3012 | HIST1H2AE | P30T-E | Human | Esophagus | ESCC | 3.29e-10 | 5.48e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383A>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383N>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383N>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2AE | SNV | Missense_Mutation | c.103N>T | p.Leu35Phe | p.L35F | P04908 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(1) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383A>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HIST1H2AE | SNV | Missense_Mutation | c.107N>A | p.Arg36His | p.R36H | P04908 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.956) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383A>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383A>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2AE | SNV | Missense_Mutation | novel | c.383N>T | p.Lys128Met | p.K128M | P04908 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
HIST1H2AE | SNV | Missense_Mutation | c.193N>C | p.Glu65Gln | p.E65Q | P04908 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.999) | TCGA-AR-A24S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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