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Gene: HINT2 |
Gene summary for HINT2 |
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Gene information | Species | Human | Gene symbol | HINT2 | Gene ID | 84681 |
Gene name | histidine triad nucleotide binding protein 2 | |
Gene Alias | HIT-17 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9BX68 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84681 | HINT2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.14e-04 | 1.39e-01 | 0.0155 |
84681 | HINT2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.01e-07 | 2.73e-01 | -0.1808 |
84681 | HINT2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.85e-03 | 2.44e-01 | -0.0811 |
84681 | HINT2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.98e-16 | 3.47e-01 | -0.1954 |
84681 | HINT2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.07e-03 | 3.86e-01 | -0.2196 |
84681 | HINT2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.08e-05 | 2.47e-01 | -0.1207 |
84681 | HINT2 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.62e-05 | 2.48e-01 | -0.1526 |
84681 | HINT2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.56e-11 | 2.59e-01 | -0.1464 |
84681 | HINT2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.76e-04 | 1.38e-01 | -0.1001 |
84681 | HINT2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.15e-11 | 3.16e-01 | -0.059 |
84681 | HINT2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.49e-08 | 4.34e-01 | -0.1706 |
84681 | HINT2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.09e-04 | 2.70e-01 | -0.2061 |
84681 | HINT2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.53e-07 | 3.79e-01 | -0.1462 |
84681 | HINT2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.47e-06 | 3.09e-01 | -0.0842 |
84681 | HINT2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.93e-02 | 2.07e-01 | -0.0179 |
84681 | HINT2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.72e-10 | 2.73e-01 | 0.096 |
84681 | HINT2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.17e-03 | 2.97e-01 | 0.0528 |
84681 | HINT2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.67e-04 | 3.74e-01 | 0.0131 |
84681 | HINT2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.18e-07 | 4.86e-01 | 0.0171 |
84681 | HINT2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.91e-06 | 2.30e-01 | 0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00160421 | Colorectum | SER | lipid catabolic process | 77/2897 | 320/18723 | 3.52e-05 | 9.18e-04 | 77 |
GO:1901984 | Colorectum | SER | negative regulation of protein acetylation | 10/2897 | 24/18723 | 1.88e-03 | 1.90e-02 | 10 |
GO:2000757 | Colorectum | SER | negative regulation of peptidyl-lysine acetylation | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
GO:00160422 | Colorectum | MSS | lipid catabolic process | 77/3467 | 320/18723 | 7.43e-03 | 4.71e-02 | 77 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:20007564 | Esophagus | ESCC | regulation of peptidyl-lysine acetylation | 43/8552 | 63/18723 | 2.43e-04 | 1.50e-03 | 43 |
GO:19019835 | Esophagus | ESCC | regulation of protein acetylation | 49/8552 | 77/18723 | 1.12e-03 | 5.60e-03 | 49 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:20007574 | Esophagus | ESCC | negative regulation of peptidyl-lysine acetylation | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:00160427 | Esophagus | ESCC | lipid catabolic process | 168/8552 | 320/18723 | 7.97e-03 | 2.84e-02 | 168 |
GO:19019844 | Esophagus | ESCC | negative regulation of protein acetylation | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HINT2 | SNV | Missense_Mutation | rs751219625 | c.296N>A | p.Arg99Gln | p.R99Q | Q9BX68 | protein_coding | tolerated(0.85) | benign(0.058) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HINT2 | SNV | Missense_Mutation | c.245C>T | p.Ala82Val | p.A82V | Q9BX68 | protein_coding | deleterious(0.02) | possibly_damaging(0.474) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HINT2 | SNV | Missense_Mutation | novel | c.320N>G | p.Asp107Gly | p.D107G | Q9BX68 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HINT2 | SNV | Missense_Mutation | novel | c.429N>C | p.Gln143His | p.Q143H | Q9BX68 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HINT2 | SNV | Missense_Mutation | novel | c.161N>T | p.Thr54Ile | p.T54I | Q9BX68 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
HINT2 | SNV | Missense_Mutation | c.466N>T | p.Arg156Trp | p.R156W | Q9BX68 | protein_coding | deleterious(0.02) | possibly_damaging(0.793) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HINT2 | SNV | Missense_Mutation | novel | c.89N>C | p.Gly30Ala | p.G30A | Q9BX68 | protein_coding | tolerated(0.5) | benign(0.001) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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