Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HINFP

Gene summary for HINFP

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HINFP

Gene ID

25988

Gene namehistone H4 transcription factor
Gene AliasHiNF-P
Cytomap11q23.3
Gene Typeprotein-coding
GO ID

GO:0000075

UniProtAcc

Q9BQA5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
25988HINFPLZE22THumanEsophagusESCC8.39e-065.19e-010.068
25988HINFPLZE24THumanEsophagusESCC3.59e-112.42e-010.0596
25988HINFPP2T-EHumanEsophagusESCC3.75e-078.70e-020.1177
25988HINFPP4T-EHumanEsophagusESCC3.77e-112.18e-010.1323
25988HINFPP8T-EHumanEsophagusESCC5.74e-182.40e-010.0889
25988HINFPP9T-EHumanEsophagusESCC1.06e-026.52e-020.1131
25988HINFPP10T-EHumanEsophagusESCC4.43e-121.37e-010.116
25988HINFPP11T-EHumanEsophagusESCC7.36e-072.51e-010.1426
25988HINFPP12T-EHumanEsophagusESCC3.21e-132.07e-010.1122
25988HINFPP16T-EHumanEsophagusESCC2.61e-142.05e-010.1153
25988HINFPP20T-EHumanEsophagusESCC1.21e-061.04e-010.1124
25988HINFPP21T-EHumanEsophagusESCC1.01e-091.74e-010.1617
25988HINFPP22T-EHumanEsophagusESCC3.20e-043.79e-020.1236
25988HINFPP23T-EHumanEsophagusESCC1.66e-057.59e-020.108
25988HINFPP26T-EHumanEsophagusESCC5.47e-111.57e-010.1276
25988HINFPP27T-EHumanEsophagusESCC8.76e-091.18e-010.1055
25988HINFPP28T-EHumanEsophagusESCC4.78e-047.34e-020.1149
25988HINFPP30T-EHumanEsophagusESCC8.21e-062.76e-010.137
25988HINFPP31T-EHumanEsophagusESCC3.28e-141.64e-010.1251
25988HINFPP32T-EHumanEsophagusESCC3.77e-081.38e-010.1666
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004477216EsophagusESCCmitotic cell cycle phase transition281/8552424/187234.63e-184.45e-16281
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:190198713EsophagusESCCregulation of cell cycle phase transition242/8552390/187233.86e-111.26e-09242
GO:00457865EsophagusESCCnegative regulation of cell cycle236/8552385/187233.62e-109.93e-09236
GO:00000754EsophagusESCCcell cycle checkpoint117/8552169/187234.47e-101.17e-08117
GO:004277014EsophagusESCCsignal transduction in response to DNA damage117/8552172/187232.38e-095.32e-08117
GO:00109484EsophagusESCCnegative regulation of cell cycle process177/8552294/187233.26e-074.59e-06177
GO:000008214EsophagusESCCG1/S transition of mitotic cell cycle134/8552214/187234.04e-075.55e-06134
GO:004484314EsophagusESCCcell cycle G1/S phase transition148/8552241/187235.68e-077.48e-06148
GO:00315705EsophagusESCCDNA integrity checkpoint83/8552123/187238.17e-071.06e-0583
GO:00000775EsophagusESCCDNA damage checkpoint78/8552115/187231.27e-061.56e-0578
GO:19019883EsophagusESCCnegative regulation of cell cycle phase transition151/8552249/187231.28e-061.57e-05151
GO:00454454EsophagusESCCmyoblast differentiation52/855284/187231.98e-038.90e-0352
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HINFPECMOral cavityEOLPRP11-326I11.3,PGF,RP11-473I1.5, etc.1.38e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HINFPSMCOral cavityHealthyRP11-326I11.3,PGF,RP11-473I1.5, etc.1.72e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HINFPPERIOral cavityHealthyRP11-326I11.3,PGF,RP11-473I1.5, etc.1.01e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HINFPSNVMissense_Mutationnovelc.1271T>Cp.Leu424Prop.L424PQ9BQA5protein_codingtolerated(0.05)benign(0.001)TCGA-AO-A0J9-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamidePD
HINFPSNVMissense_Mutationrs769670744c.61N>Gp.Ser21Alap.S21AQ9BQA5protein_codingtolerated(0.12)benign(0.007)TCGA-BH-A0BR-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HINFPSNVMissense_Mutationnovelc.1523N>Cp.Ile508Thrp.I508TQ9BQA5protein_codingtolerated(0.81)benign(0)TCGA-BH-A0HX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadrimycinSD
HINFPinsertionFrame_Shift_Insnovelc.1524_1525insAACATp.Ala509AsnfsTer35p.A509Nfs*35Q9BQA5protein_codingTCGA-BH-A0HX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadrimycinSD
HINFPSNVMissense_Mutationnovelc.629N>Gp.Asn210Serp.N210SQ9BQA5protein_codingtolerated(0.25)probably_damaging(0.998)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HINFPSNVMissense_Mutationrs760606813c.829N>Tp.Arg277Cysp.R277CQ9BQA5protein_codingdeleterious(0)probably_damaging(0.999)TCGA-EX-A69L-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
HINFPSNVMissense_Mutationnovelc.25N>Gp.Arg9Glyp.R9GQ9BQA5protein_codingtolerated(0.12)benign(0.003)TCGA-EX-A8YF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
HINFPSNVMissense_Mutationrs558542812c.1220G>Ap.Arg407Glnp.R407QQ9BQA5protein_codingtolerated(0.15)benign(0.001)TCGA-A6-2686-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
HINFPSNVMissense_Mutationc.96N>Ap.Phe32Leup.F32LQ9BQA5protein_codingtolerated(0.19)probably_damaging(0.97)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
HINFPSNVMissense_Mutationc.384C>Ap.His128Glnp.H128QQ9BQA5protein_codingtolerated(0.43)benign(0.105)TCGA-AA-3697-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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