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Gene: HINFP |
Gene summary for HINFP |
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Gene information | Species | Human | Gene symbol | HINFP | Gene ID | 25988 |
Gene name | histone H4 transcription factor | |
Gene Alias | HiNF-P | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9BQA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25988 | HINFP | LZE22T | Human | Esophagus | ESCC | 8.39e-06 | 5.19e-01 | 0.068 |
25988 | HINFP | LZE24T | Human | Esophagus | ESCC | 3.59e-11 | 2.42e-01 | 0.0596 |
25988 | HINFP | P2T-E | Human | Esophagus | ESCC | 3.75e-07 | 8.70e-02 | 0.1177 |
25988 | HINFP | P4T-E | Human | Esophagus | ESCC | 3.77e-11 | 2.18e-01 | 0.1323 |
25988 | HINFP | P8T-E | Human | Esophagus | ESCC | 5.74e-18 | 2.40e-01 | 0.0889 |
25988 | HINFP | P9T-E | Human | Esophagus | ESCC | 1.06e-02 | 6.52e-02 | 0.1131 |
25988 | HINFP | P10T-E | Human | Esophagus | ESCC | 4.43e-12 | 1.37e-01 | 0.116 |
25988 | HINFP | P11T-E | Human | Esophagus | ESCC | 7.36e-07 | 2.51e-01 | 0.1426 |
25988 | HINFP | P12T-E | Human | Esophagus | ESCC | 3.21e-13 | 2.07e-01 | 0.1122 |
25988 | HINFP | P16T-E | Human | Esophagus | ESCC | 2.61e-14 | 2.05e-01 | 0.1153 |
25988 | HINFP | P20T-E | Human | Esophagus | ESCC | 1.21e-06 | 1.04e-01 | 0.1124 |
25988 | HINFP | P21T-E | Human | Esophagus | ESCC | 1.01e-09 | 1.74e-01 | 0.1617 |
25988 | HINFP | P22T-E | Human | Esophagus | ESCC | 3.20e-04 | 3.79e-02 | 0.1236 |
25988 | HINFP | P23T-E | Human | Esophagus | ESCC | 1.66e-05 | 7.59e-02 | 0.108 |
25988 | HINFP | P26T-E | Human | Esophagus | ESCC | 5.47e-11 | 1.57e-01 | 0.1276 |
25988 | HINFP | P27T-E | Human | Esophagus | ESCC | 8.76e-09 | 1.18e-01 | 0.1055 |
25988 | HINFP | P28T-E | Human | Esophagus | ESCC | 4.78e-04 | 7.34e-02 | 0.1149 |
25988 | HINFP | P30T-E | Human | Esophagus | ESCC | 8.21e-06 | 2.76e-01 | 0.137 |
25988 | HINFP | P31T-E | Human | Esophagus | ESCC | 3.28e-14 | 1.64e-01 | 0.1251 |
25988 | HINFP | P32T-E | Human | Esophagus | ESCC | 3.77e-08 | 1.38e-01 | 0.1666 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:000008214 | Esophagus | ESCC | G1/S transition of mitotic cell cycle | 134/8552 | 214/18723 | 4.04e-07 | 5.55e-06 | 134 |
GO:004484314 | Esophagus | ESCC | cell cycle G1/S phase transition | 148/8552 | 241/18723 | 5.68e-07 | 7.48e-06 | 148 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:00454454 | Esophagus | ESCC | myoblast differentiation | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HINFP | SNV | Missense_Mutation | novel | c.1271T>C | p.Leu424Pro | p.L424P | Q9BQA5 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
HINFP | SNV | Missense_Mutation | rs769670744 | c.61N>G | p.Ser21Ala | p.S21A | Q9BQA5 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HINFP | SNV | Missense_Mutation | novel | c.1523N>C | p.Ile508Thr | p.I508T | Q9BQA5 | protein_coding | tolerated(0.81) | benign(0) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
HINFP | insertion | Frame_Shift_Ins | novel | c.1524_1525insAACAT | p.Ala509AsnfsTer35 | p.A509Nfs*35 | Q9BQA5 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
HINFP | SNV | Missense_Mutation | novel | c.629N>G | p.Asn210Ser | p.N210S | Q9BQA5 | protein_coding | tolerated(0.25) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HINFP | SNV | Missense_Mutation | rs760606813 | c.829N>T | p.Arg277Cys | p.R277C | Q9BQA5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EX-A69L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HINFP | SNV | Missense_Mutation | novel | c.25N>G | p.Arg9Gly | p.R9G | Q9BQA5 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-EX-A8YF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
HINFP | SNV | Missense_Mutation | rs558542812 | c.1220G>A | p.Arg407Gln | p.R407Q | Q9BQA5 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HINFP | SNV | Missense_Mutation | c.96N>A | p.Phe32Leu | p.F32L | Q9BQA5 | protein_coding | tolerated(0.19) | probably_damaging(0.97) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HINFP | SNV | Missense_Mutation | c.384C>A | p.His128Gln | p.H128Q | Q9BQA5 | protein_coding | tolerated(0.43) | benign(0.105) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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