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Gene: HHLA3 |
Gene summary for HHLA3 |
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Gene information | Species | Human | Gene symbol | HHLA3 | Gene ID | 11147 |
Gene name | HERV-H LTR-associating 3 | |
Gene Alias | HHLA3 | |
Cytomap | 1p31.1 | |
Gene Type | ncRNA | GO ID | GO:0003674 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11147 | HHLA3 | HCC1_Meng | Human | Liver | HCC | 1.84e-51 | 7.91e-02 | 0.0246 |
11147 | HHLA3 | HCC2_Meng | Human | Liver | HCC | 7.03e-03 | 4.91e-04 | 0.0107 |
11147 | HHLA3 | HCC1 | Human | Liver | HCC | 8.50e-06 | 2.74e+00 | 0.5336 |
11147 | HHLA3 | S014 | Human | Liver | HCC | 3.51e-12 | 4.07e-01 | 0.2254 |
11147 | HHLA3 | S015 | Human | Liver | HCC | 4.03e-07 | 5.06e-01 | 0.2375 |
11147 | HHLA3 | S016 | Human | Liver | HCC | 2.36e-10 | 3.75e-01 | 0.2243 |
11147 | HHLA3 | S028 | Human | Liver | HCC | 2.29e-03 | 2.39e-01 | 0.2503 |
11147 | HHLA3 | S029 | Human | Liver | HCC | 2.67e-05 | 3.57e-01 | 0.2581 |
11147 | HHLA3 | C04 | Human | Oral cavity | OSCC | 3.19e-17 | 9.01e-01 | 0.2633 |
11147 | HHLA3 | C21 | Human | Oral cavity | OSCC | 1.71e-13 | 4.47e-01 | 0.2678 |
11147 | HHLA3 | C30 | Human | Oral cavity | OSCC | 2.47e-10 | 4.40e-01 | 0.3055 |
11147 | HHLA3 | C43 | Human | Oral cavity | OSCC | 9.31e-07 | 1.61e-01 | 0.1704 |
11147 | HHLA3 | C46 | Human | Oral cavity | OSCC | 2.02e-08 | 2.91e-01 | 0.1673 |
11147 | HHLA3 | C57 | Human | Oral cavity | OSCC | 1.43e-06 | 3.15e-01 | 0.1679 |
11147 | HHLA3 | C06 | Human | Oral cavity | OSCC | 1.42e-03 | 5.95e-01 | 0.2699 |
11147 | HHLA3 | C08 | Human | Oral cavity | OSCC | 9.22e-08 | 1.73e-01 | 0.1919 |
11147 | HHLA3 | C09 | Human | Oral cavity | OSCC | 5.44e-04 | 2.34e-01 | 0.1431 |
11147 | HHLA3 | LN46 | Human | Oral cavity | OSCC | 3.69e-06 | 3.17e-01 | 0.1666 |
11147 | HHLA3 | LP17 | Human | Oral cavity | LP | 2.39e-05 | 5.83e-01 | 0.2349 |
11147 | HHLA3 | SYSMH2 | Human | Oral cavity | OSCC | 7.28e-03 | 1.39e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HHLA3 | SNV | Missense_Mutation | novel | c.61G>A | p.Glu21Lys | p.E21K | Q9XRX5 | protein_coding | deleterious_low_confidence(0.02) | benign(0.068) | TCGA-BH-A42V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HHLA3 | SNV | Missense_Mutation | c.360N>T | p.Lys120Asn | p.K120N | Q9XRX5 | protein_coding | possibly_damaging(0.607) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
HHLA3 | SNV | Missense_Mutation | novel | c.154G>C | p.Ala52Pro | p.A52P | Q9XRX5 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.898) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HHLA3 | SNV | Missense_Mutation | c.172G>A | p.Gly58Arg | p.G58R | Q9XRX5 | protein_coding | deleterious_low_confidence(0.04) | benign(0.007) | TCGA-AG-4015-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HHLA3 | SNV | Missense_Mutation | novel | c.146T>G | p.Leu49Arg | p.L49R | Q9XRX5 | protein_coding | deleterious_low_confidence(0) | benign(0.422) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HHLA3 | SNV | Missense_Mutation | c.163N>A | p.Leu55Ile | p.L55I | Q9XRX5 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.567) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HHLA3 | SNV | Missense_Mutation | c.325N>A | p.Ser109Thr | p.S109T | Q9XRX5 | protein_coding | benign(0.294) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HHLA3 | SNV | Missense_Mutation | novel | c.130A>G | p.Thr44Ala | p.T44A | Q9XRX5 | protein_coding | tolerated_low_confidence(0.1) | benign(0.062) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HHLA3 | SNV | Missense_Mutation | novel | c.55N>A | p.Ala19Thr | p.A19T | Q9XRX5 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.665) | TCGA-UF-A7JO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HHLA3 | SNV | Missense_Mutation | c.49C>T | p.Pro17Ser | p.P17S | Q9XRX5 | protein_coding | deleterious_low_confidence(0.04) | benign(0.22) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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