Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HES2

Gene summary for HES2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HES2

Gene ID

54626

Gene namehes family bHLH transcription factor 2
Gene AliasbHLHb40
Cytomap1p36.31
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q9Y543


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54626HES2LZE4THumanEsophagusESCC2.29e-052.12e-010.0811
54626HES2LZE22THumanEsophagusESCC3.18e-064.90e-010.068
54626HES2P4T-EHumanEsophagusESCC2.25e-154.59e-010.1323
54626HES2P5T-EHumanEsophagusESCC5.56e-103.79e-010.1327
54626HES2P9T-EHumanEsophagusESCC4.38e-062.29e-010.1131
54626HES2P12T-EHumanEsophagusESCC3.22e-021.56e-010.1122
54626HES2P15T-EHumanEsophagusESCC1.91e-215.43e-010.1149
54626HES2P17T-EHumanEsophagusESCC3.28e-043.10e-010.1278
54626HES2P20T-EHumanEsophagusESCC2.71e-041.90e-010.1124
54626HES2P21T-EHumanEsophagusESCC5.33e-092.35e-010.1617
54626HES2P22T-EHumanEsophagusESCC7.30e-091.69e-010.1236
54626HES2P23T-EHumanEsophagusESCC5.20e-092.62e-010.108
54626HES2P24T-EHumanEsophagusESCC1.03e-144.58e-010.1287
54626HES2P26T-EHumanEsophagusESCC1.10e-048.59e-020.1276
54626HES2P27T-EHumanEsophagusESCC8.96e-133.03e-010.1055
54626HES2P28T-EHumanEsophagusESCC3.24e-113.29e-010.1149
54626HES2P30T-EHumanEsophagusESCC6.35e-063.19e-010.137
54626HES2P32T-EHumanEsophagusESCC1.04e-021.09e-010.1666
54626HES2P36T-EHumanEsophagusESCC5.00e-021.97e-010.1187
54626HES2P37T-EHumanEsophagusESCC2.02e-072.22e-010.1371
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005076710EsophagusESCCregulation of neurogenesis203/8552364/187236.10e-054.68e-04203
GO:00519606EsophagusESCCregulation of nervous system development237/8552443/187235.02e-042.78e-03237
GO:00507674LiverHCCregulation of neurogenesis181/7958364/187233.00e-031.40e-02181
GO:00507679Oral cavityOSCCregulation of neurogenesis179/7305364/187234.49e-053.84e-04179
GO:00519605Oral cavityOSCCregulation of nervous system development205/7305443/187239.80e-045.11e-03205
GO:005076722SkincSCCregulation of neurogenesis118/4864364/187233.32e-031.81e-02118
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0516510EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa0516515EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa051652LiverHCCHuman papillomavirus infection188/4020331/84653.34e-041.49e-038.29e-04188
hsa051653LiverHCCHuman papillomavirus infection188/4020331/84653.34e-041.49e-038.29e-04188
hsa051659Oral cavityOSCCHuman papillomavirus infection200/3704331/84653.83e-104.93e-092.51e-09200
hsa0516514Oral cavityOSCCHuman papillomavirus infection200/3704331/84653.83e-104.93e-092.51e-09200
hsa0516523Oral cavityLPHuman papillomavirus infection121/2418331/84658.00e-043.86e-032.49e-03121
hsa0516533Oral cavityLPHuman papillomavirus infection121/2418331/84658.00e-043.86e-032.49e-03121
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
HES2CD8TEFFCervixADJFXYD3,SERPINB3,KRT19, etc.2.43e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2M2MACCervixHSIL_HPVFXYD3,SERPINB3,KRT19, etc.1.14e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2PROEsophagusHealthyTGM1,RHOV,DYNLT3, etc.1.44e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2TRANSEsophagusHealthyTGM1,RHOV,DYNLT3, etc.1.82e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2ICAFLungHealthyOTOA,CES1,FDX1, etc.3.46e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2MVALungHealthyOTOA,CES1,FDX1, etc.1.04e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
HES2SPIOral cavityOSCCRHOV,THBD,HES4, etc.4.41e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HES2SNVMissense_Mutationnovelc.194N>Ap.Arg65Hisp.R65HQ9Y543protein_codingtolerated(0.08)benign(0.111)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
HES2SNVMissense_Mutationc.163N>Ap.Glu55Lysp.E55KQ9Y543protein_codingdeleterious(0)probably_damaging(0.997)TCGA-55-A48Y-01Lunglung adenocarcinomaMale>=65I/IIChemotherapycarboplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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