Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: HELB

Gene summary for HELB

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

HELB

Gene ID

92797

Gene nameDNA helicase B
Gene AliasDHB
Cytomap12q14.3
Gene Typeprotein-coding
GO ID

GO:0000018

UniProtAcc

Q8NG08


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
92797HELBCCI_2HumanCervixCC1.77e-115.66e-010.5249
92797HELBCCI_3HumanCervixCC1.13e-156.56e-010.516
92797HELBT1HumanCervixCC1.68e-021.26e-010.0918
92797HELBAEH-subject1HumanEndometriumAEH2.06e-083.11e-01-0.3059
92797HELBLZE4THumanEsophagusESCC3.68e-113.28e-010.0811
92797HELBLZE5THumanEsophagusESCC9.05e-032.06e-010.0514
92797HELBLZE8THumanEsophagusESCC3.73e-031.16e-010.067
92797HELBLZE24THumanEsophagusESCC9.64e-051.47e-010.0596
92797HELBP1T-EHumanEsophagusESCC2.91e-022.43e-010.0875
92797HELBP2T-EHumanEsophagusESCC2.93e-336.05e-010.1177
92797HELBP4T-EHumanEsophagusESCC3.35e-021.19e-010.1323
92797HELBP5T-EHumanEsophagusESCC7.12e-061.10e-010.1327
92797HELBP8T-EHumanEsophagusESCC1.91e-193.52e-010.0889
92797HELBP9T-EHumanEsophagusESCC1.44e-048.44e-020.1131
92797HELBP10T-EHumanEsophagusESCC1.31e-055.60e-020.116
92797HELBP11T-EHumanEsophagusESCC2.14e-062.20e-010.1426
92797HELBP12T-EHumanEsophagusESCC2.30e-117.14e-020.1122
92797HELBP15T-EHumanEsophagusESCC9.54e-051.47e-010.1149
92797HELBP16T-EHumanEsophagusESCC2.67e-182.14e-010.1153
92797HELBP21T-EHumanEsophagusESCC4.06e-091.44e-010.1617
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004227410CervixCCribosomal small subunit biogenesis23/231173/187231.33e-052.68e-0423
GO:002261310CervixCCribonucleoprotein complex biogenesis88/2311463/187232.11e-053.82e-0488
GO:004225410CervixCCribosome biogenesis62/2311299/187232.48e-054.27e-0462
GO:20010209CervixCCregulation of response to DNA damage stimulus46/2311219/187231.92e-042.23e-0346
GO:00510528CervixCCregulation of DNA metabolic process65/2311359/187239.25e-047.84e-0365
GO:00062602CervixCCDNA replication48/2311260/187232.70e-031.85e-0248
GO:00323923CervixCCDNA geometric change21/231190/187232.71e-031.85e-0221
GO:00160727CervixCCrRNA metabolic process42/2311236/187239.12e-034.60e-0242
GO:002261316EndometriumAEHribonucleoprotein complex biogenesis107/2100463/187231.43e-134.08e-11107
GO:004225416EndometriumAEHribosome biogenesis67/2100299/187231.95e-081.18e-0667
GO:004227416EndometriumAEHribosomal small subunit biogenesis22/210073/187239.73e-062.24e-0422
GO:00063648EndometriumAEHrRNA processing47/2100225/187231.78e-053.65e-0447
GO:00160728EndometriumAEHrRNA metabolic process48/2100236/187233.01e-055.54e-0448
GO:200102010EndometriumAEHregulation of response to DNA damage stimulus40/2100219/187231.28e-031.09e-0240
GO:00344707EndometriumAEHncRNA processing62/2100395/187233.93e-032.65e-0262
GO:0022613111EsophagusESCCribonucleoprotein complex biogenesis365/8552463/187231.74e-491.11e-45365
GO:0042254111EsophagusESCCribosome biogenesis252/8552299/187233.27e-441.04e-40252
GO:003447015EsophagusESCCncRNA processing300/8552395/187233.09e-353.26e-32300
GO:0016072110EsophagusESCCrRNA metabolic process197/8552236/187231.31e-331.18e-30197
GO:0006364110EsophagusESCCrRNA processing189/8552225/187234.88e-333.87e-30189
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
HELBSNVMissense_Mutationc.1193N>Tp.Ser398Ilep.S398IQ8NG08protein_codingtolerated(0.07)benign(0.365)TCGA-AN-A0XU-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HELBSNVMissense_Mutationc.194N>Cp.Ile65Thrp.I65TQ8NG08protein_codingdeleterious(0)possibly_damaging(0.541)TCGA-AR-A0TX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HELBSNVMissense_Mutationnovelc.1493G>Cp.Arg498Thrp.R498TQ8NG08protein_codingtolerated(0.14)benign(0.003)TCGA-AR-A2LN-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyletrozoleSD
HELBSNVMissense_Mutationc.2352N>Tp.Arg784Serp.R784SQ8NG08protein_codingdeleterious(0)possibly_damaging(0.666)TCGA-BH-A0RX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
HELBSNVMissense_Mutationc.2924N>Ap.Ser975Asnp.S975NQ8NG08protein_codingtolerated(0.21)benign(0.005)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
HELBSNVMissense_Mutationc.1400N>Gp.Ser467Cysp.S467CQ8NG08protein_codingdeleterious(0)possibly_damaging(0.905)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
HELBinsertionFrame_Shift_Insnovelc.1375_1376insCCp.Val459AlafsTer7p.V459Afs*7Q8NG08protein_codingTCGA-B6-A0RE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HELBinsertionFrame_Shift_Insnovelc.1376_1377insTCATTTCAACCCTCCTGGTTTTACAGAGGGGGTAGCTGp.Ala460HisfsTer18p.A460Hfs*18Q8NG08protein_codingTCGA-B6-A0RE-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
HELBSNVMissense_Mutationrs766053942c.1453N>Ap.Val485Ilep.V485IQ8NG08protein_codingdeleterious(0)probably_damaging(0.998)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
HELBSNVMissense_Mutationc.127N>Ap.Asp43Asnp.D43NQ8NG08protein_codingdeleterious(0.01)probably_damaging(0.999)TCGA-DS-A0VM-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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