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Gene: HDHD2 |
Gene summary for HDHD2 |
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Gene information | Species | Human | Gene symbol | HDHD2 | Gene ID | 84064 |
Gene name | haloacid dehalogenase like hydrolase domain containing 2 | |
Gene Alias | 3110052N05Rik | |
Cytomap | 18q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q9H0R4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84064 | HDHD2 | LZE7T | Human | Esophagus | ESCC | 2.92e-04 | 2.55e-01 | 0.0667 |
84064 | HDHD2 | LZE20T | Human | Esophagus | ESCC | 2.61e-02 | 9.65e-02 | 0.0662 |
84064 | HDHD2 | P2T-E | Human | Esophagus | ESCC | 2.81e-25 | 3.53e-01 | 0.1177 |
84064 | HDHD2 | P4T-E | Human | Esophagus | ESCC | 2.06e-15 | 3.75e-01 | 0.1323 |
84064 | HDHD2 | P5T-E | Human | Esophagus | ESCC | 2.16e-06 | 7.87e-03 | 0.1327 |
84064 | HDHD2 | P8T-E | Human | Esophagus | ESCC | 1.03e-13 | 1.02e-01 | 0.0889 |
84064 | HDHD2 | P9T-E | Human | Esophagus | ESCC | 2.19e-06 | 1.36e-01 | 0.1131 |
84064 | HDHD2 | P10T-E | Human | Esophagus | ESCC | 4.38e-17 | 2.29e-01 | 0.116 |
84064 | HDHD2 | P11T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.87e-01 | 0.1426 |
84064 | HDHD2 | P12T-E | Human | Esophagus | ESCC | 4.26e-18 | 1.86e-01 | 0.1122 |
84064 | HDHD2 | P15T-E | Human | Esophagus | ESCC | 1.19e-04 | 6.15e-02 | 0.1149 |
84064 | HDHD2 | P16T-E | Human | Esophagus | ESCC | 7.28e-21 | 3.68e-01 | 0.1153 |
84064 | HDHD2 | P20T-E | Human | Esophagus | ESCC | 3.17e-08 | 1.11e-01 | 0.1124 |
84064 | HDHD2 | P21T-E | Human | Esophagus | ESCC | 1.71e-06 | 1.04e-01 | 0.1617 |
84064 | HDHD2 | P22T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.97e-01 | 0.1236 |
84064 | HDHD2 | P23T-E | Human | Esophagus | ESCC | 1.91e-11 | 3.59e-01 | 0.108 |
84064 | HDHD2 | P24T-E | Human | Esophagus | ESCC | 3.63e-12 | 1.48e-01 | 0.1287 |
84064 | HDHD2 | P26T-E | Human | Esophagus | ESCC | 1.22e-22 | 3.84e-01 | 0.1276 |
84064 | HDHD2 | P27T-E | Human | Esophagus | ESCC | 5.10e-13 | 1.66e-01 | 0.1055 |
84064 | HDHD2 | P28T-E | Human | Esophagus | ESCC | 4.06e-17 | 1.59e-01 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDHD2 | SNV | Missense_Mutation | c.205N>C | p.Glu69Gln | p.E69Q | Q9H0R4 | protein_coding | tolerated(0.4) | benign(0.055) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
HDHD2 | SNV | Missense_Mutation | novel | c.217N>C | p.Phe73Leu | p.F73L | Q9H0R4 | protein_coding | tolerated(0.05) | benign(0.291) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD2 | SNV | Missense_Mutation | novel | c.649N>A | p.Gly217Ser | p.G217S | Q9H0R4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HDHD2 | SNV | Missense_Mutation | rs374468528 | c.14N>A | p.Arg5His | p.R5H | Q9H0R4 | protein_coding | tolerated(0.1) | benign(0.033) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HDHD2 | insertion | Frame_Shift_Ins | novel | c.534_535insG | p.Lys179GlufsTer17 | p.K179Efs*17 | Q9H0R4 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
HDHD2 | SNV | Missense_Mutation | novel | c.185A>C | p.Lys62Thr | p.K62T | Q9H0R4 | protein_coding | tolerated(0.09) | benign(0.024) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDHD2 | SNV | Missense_Mutation | novel | c.257N>C | p.Lys86Thr | p.K86T | Q9H0R4 | protein_coding | tolerated(0.14) | benign(0.024) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDHD2 | SNV | Missense_Mutation | novel | c.546G>T | p.Lys182Asn | p.K182N | Q9H0R4 | protein_coding | tolerated(0.09) | benign(0.177) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HDHD2 | SNV | Missense_Mutation | novel | c.421N>T | p.Ile141Leu | p.I141L | Q9H0R4 | protein_coding | deleterious(0.05) | benign(0.364) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDHD2 | SNV | Missense_Mutation | rs772089622 | c.568N>T | p.Arg190Trp | p.R190W | Q9H0R4 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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