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Gene: HDGFL3 |
Gene summary for HDGFL3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HDGFL3 | Gene ID | 50810 |
| Gene name | HDGF like 3 | |
| Gene Alias | CGI-142 | |
| Cytomap | 15q25.2 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A0A024R216 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 50810 | HDGFL3 | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 6.95e-01 | 0.082 |
| 50810 | HDGFL3 | LZE4T | Human | Esophagus | ESCC | 2.35e-12 | 4.15e-01 | 0.0811 |
| 50810 | HDGFL3 | LZE7T | Human | Esophagus | ESCC | 5.23e-19 | 9.14e-01 | 0.0667 |
| 50810 | HDGFL3 | LZE8T | Human | Esophagus | ESCC | 2.72e-03 | 1.89e-01 | 0.067 |
| 50810 | HDGFL3 | LZE24T | Human | Esophagus | ESCC | 1.28e-07 | 1.99e-01 | 0.0596 |
| 50810 | HDGFL3 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 3.11e-01 | 0.0845 |
| 50810 | HDGFL3 | male-WTA | Human | Thyroid | PTC | 2.53e-27 | 3.46e-01 | 0.1037 |
| 50810 | HDGFL3 | PTC01 | Human | Thyroid | PTC | 2.71e-09 | 2.47e-01 | 0.1899 |
| 50810 | HDGFL3 | PTC03 | Human | Thyroid | PTC | 3.54e-03 | 2.01e-01 | 0.1784 |
| 50810 | HDGFL3 | PTC04 | Human | Thyroid | PTC | 5.13e-22 | 3.77e-01 | 0.1927 |
| 50810 | HDGFL3 | PTC05 | Human | Thyroid | PTC | 2.38e-23 | 6.27e-01 | 0.2065 |
| 50810 | HDGFL3 | PTC06 | Human | Thyroid | PTC | 1.62e-41 | 8.25e-01 | 0.2057 |
| 50810 | HDGFL3 | PTC07 | Human | Thyroid | PTC | 2.83e-29 | 5.89e-01 | 0.2044 |
| 50810 | HDGFL3 | ATC09 | Human | Thyroid | ATC | 2.26e-06 | 2.81e-01 | 0.2871 |
| 50810 | HDGFL3 | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 8.01e-01 | 0.3386 |
| 50810 | HDGFL3 | ATC12 | Human | Thyroid | ATC | 1.72e-28 | 5.08e-01 | 0.34 |
| 50810 | HDGFL3 | ATC13 | Human | Thyroid | ATC | 4.01e-71 | 1.20e+00 | 0.34 |
| 50810 | HDGFL3 | ATC1 | Human | Thyroid | ATC | 1.52e-06 | 3.11e-01 | 0.2878 |
| 50810 | HDGFL3 | ATC2 | Human | Thyroid | ATC | 8.62e-27 | 1.40e+00 | 0.34 |
| 50810 | HDGFL3 | ATC3 | Human | Thyroid | ATC | 6.48e-06 | 5.18e-01 | 0.338 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
| GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
| GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
| GO:0051258111 | Esophagus | ESCC | protein polymerization | 183/8552 | 297/18723 | 1.94e-08 | 3.75e-07 | 183 |
| GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
| GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
| GO:00467856 | Esophagus | ESCC | microtubule polymerization | 55/8552 | 83/18723 | 1.21e-04 | 8.31e-04 | 55 |
| GO:00432446 | Esophagus | ESCC | regulation of protein-containing complex disassembly | 75/8552 | 121/18723 | 2.17e-04 | 1.36e-03 | 75 |
| GO:00311104 | Esophagus | ESCC | regulation of microtubule polymerization or depolymerization | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
| GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
| GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
| GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
| GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
| GO:0051258113 | Thyroid | PTC | protein polymerization | 154/5968 | 297/18723 | 5.35e-13 | 2.66e-11 | 154 |
| GO:0032984110 | Thyroid | PTC | protein-containing complex disassembly | 114/5968 | 224/18723 | 2.26e-09 | 6.33e-08 | 114 |
| GO:0010639112 | Thyroid | PTC | negative regulation of organelle organization | 163/5968 | 348/18723 | 3.04e-09 | 8.39e-08 | 163 |
| GO:007050717 | Thyroid | PTC | regulation of microtubule cytoskeleton organization | 80/5968 | 148/18723 | 1.79e-08 | 4.19e-07 | 80 |
| GO:1902904111 | Thyroid | PTC | negative regulation of supramolecular fiber organization | 78/5968 | 167/18723 | 4.16e-05 | 3.80e-04 | 78 |
| GO:00328866 | Thyroid | PTC | regulation of microtubule-based process | 105/5968 | 240/18723 | 6.91e-05 | 6.03e-04 | 105 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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