Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HDGF_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HDGF_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HDGF_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HDGF_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HDGF_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HDGF_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HDGF_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HDGF_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HDGF_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0098760 | Colorectum | AD | response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:0098761 | Colorectum | AD | cellular response to interleukin-7 | 10/3918 | 15/18723 | 1.68e-04 | 2.29e-03 | 10 |
GO:00987601 | Colorectum | SER | response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987611 | Colorectum | SER | cellular response to interleukin-7 | 8/2897 | 15/18723 | 7.51e-04 | 9.68e-03 | 8 |
GO:00987602 | Colorectum | MSS | response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00987612 | Colorectum | MSS | cellular response to interleukin-7 | 10/3467 | 15/18723 | 5.64e-05 | 9.87e-04 | 10 |
GO:00987603 | Colorectum | MSI-H | response to interleukin-7 | 8/1319 | 15/18723 | 2.44e-06 | 1.43e-04 | 8 |
GO:00987613 | Colorectum | MSI-H | cellular response to interleukin-7 | 8/1319 | 15/18723 | 2.44e-06 | 1.43e-04 | 8 |
GO:00987604 | Colorectum | FAP | response to interleukin-7 | 8/2622 | 15/18723 | 3.75e-04 | 4.63e-03 | 8 |
GO:00987614 | Colorectum | FAP | cellular response to interleukin-7 | 8/2622 | 15/18723 | 3.75e-04 | 4.63e-03 | 8 |
GO:009876010 | Endometrium | AEH | response to interleukin-7 | 6/2100 | 15/18723 | 4.03e-03 | 2.69e-02 | 6 |
GO:009876110 | Endometrium | AEH | cellular response to interleukin-7 | 6/2100 | 15/18723 | 4.03e-03 | 2.69e-02 | 6 |
GO:009876014 | Endometrium | EEC | response to interleukin-7 | 6/2168 | 15/18723 | 4.74e-03 | 3.00e-02 | 6 |
GO:009876114 | Endometrium | EEC | cellular response to interleukin-7 | 6/2168 | 15/18723 | 4.74e-03 | 3.00e-02 | 6 |
GO:009876019 | Esophagus | HGIN | response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:009876119 | Esophagus | HGIN | cellular response to interleukin-7 | 8/2587 | 15/18723 | 3.41e-04 | 5.55e-03 | 8 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDGF | SNV | Missense_Mutation | novel | c.706G>A | p.Glu236Lys | p.E236K | P51858 | protein_coding | tolerated_low_confidence(0.08) | benign(0.074) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
HDGF | SNV | Missense_Mutation | novel | c.447N>A | p.Ser149Arg | p.S149R | P51858 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HDGF | insertion | Nonsense_Mutation | novel | c.150_159dupTGAGGCTGCC | p.Val54Ter | p.V54* | P51858 | protein_coding | | | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HDGF | SNV | Missense_Mutation | | c.434N>T | p.Ala145Val | p.A145V | P51858 | protein_coding | deleterious(0) | benign(0.062) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HDGF | SNV | Missense_Mutation | novel | c.569A>C | p.Asn190Thr | p.N190T | P51858 | protein_coding | tolerated(0.15) | benign(0.01) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HDGF | SNV | Missense_Mutation | | c.212C>T | p.Thr71Met | p.T71M | P51858 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
HDGF | insertion | Frame_Shift_Ins | novel | c.197_198insT | p.Gly67ArgfsTer63 | p.G67Rfs*63 | P51858 | protein_coding | | | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDGF | SNV | Missense_Mutation | novel | c.745N>T | p.Gly249Cys | p.G249C | P51858 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HDGF | SNV | Missense_Mutation | novel | c.461N>G | p.Lys154Arg | p.K154R | P51858 | protein_coding | tolerated(0.05) | possibly_damaging(0.702) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDGF | SNV | Missense_Mutation | | c.106N>T | p.Pro36Ser | p.P36S | P51858 | protein_coding | tolerated_low_confidence(0.96) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |