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Gene: HCFC1R1 |
Gene summary for HCFC1R1 |
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Gene information | Species | Human | Gene symbol | HCFC1R1 | Gene ID | 54985 |
Gene name | host cell factor C1 regulator 1 | |
Gene Alias | HPIP | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NWW0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54985 | HCFC1R1 | AEH-subject1 | Human | Endometrium | AEH | 9.88e-15 | -4.30e-01 | -0.3059 |
54985 | HCFC1R1 | AEH-subject2 | Human | Endometrium | AEH | 1.54e-04 | -2.66e-01 | -0.2525 |
54985 | HCFC1R1 | AEH-subject3 | Human | Endometrium | AEH | 2.08e-16 | -4.47e-01 | -0.2576 |
54985 | HCFC1R1 | AEH-subject4 | Human | Endometrium | AEH | 5.45e-08 | -4.29e-01 | -0.2657 |
54985 | HCFC1R1 | AEH-subject5 | Human | Endometrium | AEH | 9.43e-12 | -4.20e-01 | -0.2953 |
54985 | HCFC1R1 | EEC-subject1 | Human | Endometrium | EEC | 2.73e-29 | -4.87e-01 | -0.2682 |
54985 | HCFC1R1 | EEC-subject2 | Human | Endometrium | EEC | 2.45e-12 | -4.08e-01 | -0.2607 |
54985 | HCFC1R1 | EEC-subject3 | Human | Endometrium | EEC | 1.02e-41 | -5.12e-01 | -0.2525 |
54985 | HCFC1R1 | EEC-subject4 | Human | Endometrium | EEC | 7.55e-14 | -4.21e-01 | -0.2571 |
54985 | HCFC1R1 | EEC-subject5 | Human | Endometrium | EEC | 2.49e-11 | -3.29e-01 | -0.249 |
54985 | HCFC1R1 | GSM5276934 | Human | Endometrium | EEC | 5.71e-12 | -3.88e-01 | -0.0913 |
54985 | HCFC1R1 | GSM5276935 | Human | Endometrium | EEC | 9.85e-05 | -2.83e-01 | -0.123 |
54985 | HCFC1R1 | GSM5276937 | Human | Endometrium | EEC | 2.59e-05 | -3.71e-01 | -0.0897 |
54985 | HCFC1R1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 7.54e-21 | -4.53e-01 | -0.1869 |
54985 | HCFC1R1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.25e-19 | -4.98e-01 | -0.1875 |
54985 | HCFC1R1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.00e-24 | -4.92e-01 | -0.1883 |
54985 | HCFC1R1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 9.43e-26 | -4.03e-01 | -0.1934 |
54985 | HCFC1R1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.38e-36 | -3.69e-01 | -0.1917 |
54985 | HCFC1R1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.93e-32 | -3.76e-01 | -0.1916 |
54985 | HCFC1R1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.21e-02 | -1.67e-01 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HCFC1R1 | SNV | Missense_Mutation | novel | c.145N>C | p.Glu49Gln | p.E49Q | Q9NWW0 | protein_coding | tolerated_low_confidence(0.06) | benign(0.342) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
HCFC1R1 | SNV | Missense_Mutation | novel | c.362A>G | p.Asp121Gly | p.D121G | Q9NWW0 | protein_coding | tolerated_low_confidence(0.18) | benign(0.011) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
HCFC1R1 | SNV | Missense_Mutation | rs762463939 | c.26N>A | p.Arg9Gln | p.R9Q | Q9NWW0 | protein_coding | tolerated_low_confidence(0.07) | benign(0.124) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HCFC1R1 | SNV | Missense_Mutation | c.374C>G | p.Pro125Arg | p.P125R | Q9NWW0 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.79) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HCFC1R1 | deletion | Frame_Shift_Del | rs768523777 | c.249delC | p.Met84Ter | p.M84* | Q9NWW0 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HCFC1R1 | deletion | Frame_Shift_Del | rs768523777 | c.249delC | p.Met84Ter | p.M84* | Q9NWW0 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HCFC1R1 | deletion | Frame_Shift_Del | rs768523777 | c.249delN | p.Met84Ter | p.M84* | Q9NWW0 | protein_coding | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | ||
HCFC1R1 | deletion | Frame_Shift_Del | rs768523777 | c.249delN | p.Met84Ter | p.M84* | Q9NWW0 | protein_coding | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HCFC1R1 | SNV | Missense_Mutation | novel | c.85N>A | p.Leu29Met | p.L29M | Q9NWW0 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.839) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HCFC1R1 | SNV | Missense_Mutation | rs558116524 | c.134N>A | p.Arg45Gln | p.R45Q | Q9NWW0 | protein_coding | tolerated_low_confidence(0.25) | benign(0.124) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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